EPIDEMIOLOGIC STUDY OF STRESS IN PREGNANCY

妊娠期压力的流行病学研究

• 批准号: 3325438
• 负责人: Maureen C. Hatch
• 金额: $ 29.77万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3325438
• 关键词: alcoholic beverage consumption; biomarker; catecholamines; community; coping; epidemiology; human ecology; human pregnant subject; human subject; lifestyle; neuroendocrine system; physiologic stressor; postpartum; pregnancy disorder; prenatal stress; psychological stressor; questionnaires; social support network; tobacco abuse; urinalysis

This proposal aims to complete a prospective study of life stress in pregnancy, an issue that has long been a concern of obstetric practitioners. The sample comprises cohorts of 500 prenatal patients assembled in each of two closely comparable areas, who are followed to six weeks postpartum. The independent variables fall into two broad exposure classes: acute individual life stressors and chronic community stressors, both measured at several points in pregnancy. The dependent variables are specific adverse outcomes for mother and offspring selected on the basis of biologic plausibility. A unique feature of the study is the use of biological markers (principally urinary catecholamine levels) to measure both physiologic response to stress and possible intervening pathways from stressors to reproductive outcome. Social support, coping and locus of control are assessed as potential moderating variables. A range of experiences known to affect pregnancy outcome - including behaviors that may be influenced by stress (e.g., smoking, drinking) - are measured as potential confounding or effect-modifying variables. Tests of the effects of acute individual stress relate to reported life events. Tests of the effects of chronic community stress depend partly on subject reports of perceived threat and partly on the comparison of two sociodemographically similar areas: one proximate to a nuclear plant (Three Mile Island); the other not; and both equally exposed to perceived threats from other environmental hazards such as radon. The study is well-launched, with all procedures fully operational. Continuity depends on timely supplemental funding.

这项建议旨在完成一项关于生活压力的前瞻性研究， 怀孕，这一问题长期以来一直是产科关注的问题， 从业者 样本包括500名产前患者的队列 聚集在两个密切可比的领域，谁是遵循六个 产后几周 自变量分为两大类 类别：急性个人生活压力源和慢性社区压力源， 都是在怀孕期间的几个时间点测量的。 因变量为 母亲和后代的特定不良后果， 生物相容性。 这项研究的一个独特之处是使用了 生物标志物（主要是尿中的儿茶酚胺水平），以测量 对压力的生理反应和可能的干预途径， 生殖结果的压力因素。 社会支持、应对方式与人格特质 控制被评估为潜在的调节变量。 一系列 已知会影响妊娠结局的经历-包括 可能受到应力的影响（例如，吸烟，饮酒）-测量为 潜在的混杂或影响修改变量。 效果测试 急性个体压力与报告的生活事件有关。 的测试 慢性社区压力的影响部分取决于主题报告， 感知的威胁，部分是对两个社会人口统计学的比较 类似的地区：一个靠近核电站（三里岛）; 其他人没有;两者都同样暴露于来自其他人的感知威胁 氡等环境危害。 这项研究已顺利启动，所有程序都已充分运作。 持续性取决于及时的补充资金。