PREVENTION OF HIGH BLOOD PRESSURE IN CHILDREN

预防儿童高血压

• 批准号: 3335992
• 负责人: RONALD J PRINEAS
• 金额: $ 41.38万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3335992
• 关键词: African American; adolescence (12-20); behavioral medicine; body physical activity; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cardiovascular disorder prevention; case history; caucasian American; clinical chemistry; creatinine; diet therapy; environment associated hypertension; familial hypertension; family structure /dynamics; human puberty; human subject; low salt diet; middle childhood (6-11); neurogenic hypertension; nutrition related tag; obesity; potassium; reducing diet; sodium; type A /type B personality

This longitudinal study will continue measuring blood pressure, height, weight, skinfold thickness and body girths of 1,082 children, now once annually. The study sample is a stable population of children selected from more than 98% of 10,500 children being all children in grades 1, 2, and 3 of the Minneapolis Public School System in the spring of 1978. All non-black or white children, all children from the top and bottom 5% of the systolic blood pressure (BP) distribution, and a 1/2 sample of black children and a 1/9 sample of white children from the rest of the BP distribution were followed 2x per year in spring and fall of 1978 to 1980 and 1982 to 1985 for BP and body size measurements. These 1,000+ children have also been visited at home in 1978 when extensive psychological, medical history, dietary history, demographic data, and overnight urine collection for Na+, K+ and creatinine have been gathered. In addition, blood pressure, height, weight, medical history, psychological data and Life Event data have been gathered on the parents together with extensive measurements of fat distribution and further medical and dietary history in 1985. In 1981 no screening was performed but consent was obtained to continue screening through the remaining years of school and beyond. In 1982, 22Na+ red blood cell (rbc) efflux rate was measured in 395 children and 617 parents. This will be repeated in 1985 together with measures of sodium lithium countertransport and sodium potassium cotransport. During the course of the study, baseline data and laboratory and Type A classification data will be used to develop predictive equations for blood pressure levels in the highest percentiles in late adolescence and young adulthood. This will include derivation of an index of "tracking" and the predictive value of this index. These may provide etiological clues to essential hypertension and allow indepth study of other factors among children to be found at highest risk. From such proposed predictive studies it will be possible to develop strategies for primary prevention and more detailed examination of etiological factors of essential hypertension.

这项纵向研究将继续测量血压、身高、 1,082名儿童的体重、皮褶厚度和体围 每年一次。研究样本是选定的稳定的儿童群体 在10,500名儿童中，超过98%的儿童都是一年级、二年级的儿童， 和3明尼阿波利斯公立学校系统在1978年春天。全 非黑人或白人儿童，来自顶层和底层的5%的儿童 收缩压(BP)分布，以及1/2的黑色样本 来自BP其余地区的儿童和1/9的白人儿童样本 1978年至1980年春、秋两季每年2次。 1982年至1985年进行血压和体型测量。这1000多名儿童 1978年也曾在家里走访过，当时广泛的心理， 病史、饮食史、人口统计数据和夜间尿液 已经收集了Na+，K+和肌酐的收集。此外, 血压、身高、体重、病史、心理数据和 关于父母的生活事件数据已经收集到了广泛的 脂肪分布的测量以及进一步的医疗和饮食病史 1985年。1981年，没有进行筛查，但获得了同意 在学校剩下的几年里和以后继续筛选。在……里面 1982年，对395名儿童进行了22Na~+红细胞(RBC)外流率测定。 以及617名家长。这将在1985年重复，同时采取下列措施 钠锂反转运和钠钾共转运。 在研究过程中，基线数据和实验室和A型 分类数据将被用来开发血液预测方程 青春期后期和青春期最高百分位数的压力水平 成人期。这将包括“跟踪”索引的派生和 这一指标的预测价值。这些可能提供病因学线索 并允许对其他因素进行深入研究 儿童被发现的风险最高。从这种建议的预测性 研究将有可能制定初级预防战略 和更详细的病因检查的基础上 高血压。