PREVENTION OF HIGH BLOOD PRESSURE IN CHILDREN

预防儿童高血压

• 批准号: 3335994
• 负责人: RONALD J PRINEAS
• 金额: $ 37.06万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1991-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3335994
• 关键词: African American; adolescence (12-20); behavioral medicine; body physical activity; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cardiovascular disorder prevention; case history; caucasian American; clinical chemistry; creatinine; diet therapy; environment associated hypertension; familial hypertension; family structure /dynamics; human puberty; human subject; low salt diet; middle childhood (6-11); neurogenic hypertension; nutrition related tag; obesity; potassium; reducing diet; sodium; type A /type B personality

This longitudinal study will continue measuring blood pressure, height, weight, skinfold thickness and body girths of 1,082 children, now once annually. The study sample is a stable population of children selected from more than 98% of 10,500 children being all children in grades 1, 2, and 3 of the Minneapolis Public School System in the spring of 1978. All non-black or white children, all children from the top and bottom 5% of the systolic blood pressure (BP) distribution, and a 1/2 sample of black children and a 1/9 sample of white children from the rest of the BP distribution were followed 2x per year in spring and fall of 1978 to 1980 and 1982 to 1985 for BP and body size measurements. These 1,000+ children have also been visited at home in 1978 when extensive psychological, medical history, dietary history, demographic data, and overnight urine collection for Na+, K+ and creatinine have been gathered. In addition, blood pressure, height, weight, medical history, psychological data and Life Event data have been gathered on the parents together with extensive measurements of fat distribution and further medical and dietary history in 1985. In 1981 no screening was performed but consent was obtained to continue screening through the remaining years of school and beyond. In 1982, 22Na+ red blood cell (rbc) efflux rate was measured in 395 children and 617 parents. This will be repeated in 1985 together with measures of sodium lithium countertransport and sodium potassium cotransport. During the course of the study, baseline data and laboratory and Type A classification data will be used to develop predictive equations for blood pressure levels in the highest percentiles in late adolescence and young adulthood. This will include derivation of an index of "tracking" and the predictive value of this index. These may provide etiological clues to essential hypertension and allow indepth study of other factors among children to be found at highest risk. From such proposed predictive studies it will be possible to develop strategies for primary prevention and more detailed examination of etiological factors of essential hypertension.

这项纵向研究将继续测量血压，身高，