Parental imprinting and epigenetic inheritance in honey bees

蜜蜂的亲代印记和表观遗传

• 批准号: DP150100151
• 负责人: Prof Benjamin Oldroyd
• 金额: $ 29.23万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100151
• 关键词: Parental; imprinting; epigenetic; inheritance; honey

This project aims to uncover the mechanisms behind epigenetic inheritance in bees, providing deep insights into their biology, and develop an outstanding new system for studying epigenetics. There are compelling theoretical and empirical reasons to predict epigenetic inheritance in honey bees. Further, reciprocal crosses reveal strong paternal effects suggesting that males modify their sperm to increase the reproductive success of their female offspring. Modification of DNA by methylation and the transfer of small RNA molecules in eggs or semen are two candidate mechanisms by which queens and drones may manipulate gene expression in their offspring.

该项目旨在揭示蜜蜂表观遗传遗传背后的机制，深入了解其生物学，并开发一个出色的表观遗传学研究新系统。有令人信服的理论和经验的理由来预测蜜蜂的表观遗传。此外，正反交揭示了强烈的父系效应，表明男性修改他们的精子，以增加其女性后代的繁殖成功率。甲基化修饰DNA和卵或精液中小RNA分子的转移是蜂王和雄蜂操纵后代基因表达的两种候选机制。