REDUCED LORDOSIS BEHAVIOR AFTER INTRACEREBRAL 8-OH DPAT

脑内 8-OH DPAT 后可减少脊柱前凸行为

基本信息

  • 批准号:
    2201077
  • 负责人:
  • 金额:
    $ 7.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1991
  • 资助国家:
    美国
  • 起止时间:
    1991-08-01 至 1995-04-30
  • 项目状态:
    已结题

项目摘要

The proposed research is designed to identify the CNS site(s) responsible for the inhibition of female rat sexual behavior after treatment with the 5-HT1A agonist, 8-hydroxy-2-9(di-n-propylamino) tetralin (8-OH-DPAT). Activation of somal/dendritic 5-HT1A autoreceptors by 8-OH-DPAT decreases the firing of 5-HT neurons and reduces the release of 5-HT in regions innervated by these neurons. In terminal fields, the 5-HT1A receptor exists at postsynaptic sites. Although it may also reside on presynaptic terminals, the 5-HT1A receptor does not function as the terminal autoreceptor. The specific aims of the proposed studies are: (1) to identify the neural areas sufficient for the inhibition of female sexual behavior following treatment with 8-OH-DPAT and (2) to compare the effectiveness of this 5-HT1A agonist with that of other 5-HT1A agonists and 5-HT1B-preferring agonists. The effects of putative 5-HT1A antagonists will also be studied. Intact, regularly cycling female rats will be used and special emphasis will be placed on differentiating the postsynaptic effects of 8-OH-DPAT will then be infused intracerebrally into the medial basal hypothalamus and medial preoptic area, terminal fields that control female reproduction, and into the dorsal raphe nucleus, which contains 5-HT cell bodies. Sexual behavior will be monitored before and after infusion. These studies will provide the foundation for future investigations aimed at identifying the molecular nature and functional consequences of 5-HT1A- mediated control of sexual behavior.
拟议的研究旨在确定负责的中枢神经系统位点

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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LYNDA L UPHOUSE其他文献

LYNDA L UPHOUSE的其他文献

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{{ truncateString('LYNDA L UPHOUSE', 18)}}的其他基金

MBRS PROGRAM AT TEXAS WOMAN'S UNIVERSITY
德克萨斯女子大学的 MBRS 项目
  • 批准号:
    6224336
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS PROGRAM AT TEXAS WOMAN'S UNIVERSITY
德克萨斯女子大学的 MBRS 项目
  • 批准号:
    6727507
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS Program at Texas Woman's University
德克萨斯女子大学 MBRS 项目
  • 批准号:
    7379907
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS PROGRAM AT TEXAS WOMAN'S UNIVERSITY
德克萨斯女子大学的 MBRS 项目
  • 批准号:
    6519798
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS Program at Texas Woman's University
德克萨斯女子大学 MBRS 项目
  • 批准号:
    6849157
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS PROGRAM AT TEXAS WOMANS UNIVERSITY
德克萨斯女子大学 MBRS 项目
  • 批准号:
    6164787
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS PROGRAM AT TEXAS WOMANS UNIVERSITY
德克萨斯女子大学 MBRS 项目
  • 批准号:
    2883059
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS Program at Texas Woman's University
德克萨斯女子大学 MBRS 项目
  • 批准号:
    7217531
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS PROGRAM AT TEXAS WOMANS UNIVERSITY
德克萨斯女子大学 MBRS 项目
  • 批准号:
    2668536
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:
MBRS PROGRAM AT TEXAS WOMANS UNIVERSITY
德克萨斯女子大学 MBRS 项目
  • 批准号:
    2023946
  • 财政年份:
    1997
  • 资助金额:
    $ 7.16万
  • 项目类别:

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