REDUCED LORDOSIS BEHAVIOR AFTER INTRACEREBRAL 8-OH DPAT
脑内 8-OH DPAT 后可减少脊柱前凸行为
基本信息
- 批准号:2201077
- 负责人:
- 金额:$ 7.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-08-01 至 1995-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The proposed research is designed to identify the CNS site(s) responsible
for the inhibition of female rat sexual behavior after treatment with the
5-HT1A agonist, 8-hydroxy-2-9(di-n-propylamino) tetralin (8-OH-DPAT).
Activation of somal/dendritic 5-HT1A autoreceptors by 8-OH-DPAT decreases
the firing of 5-HT neurons and reduces the release of 5-HT in regions
innervated by these neurons. In terminal fields, the 5-HT1A receptor
exists at postsynaptic sites. Although it may also reside on presynaptic
terminals, the 5-HT1A receptor does not function as the terminal
autoreceptor. The specific aims of the proposed studies are: (1) to
identify the neural areas sufficient for the inhibition of female sexual
behavior following treatment with 8-OH-DPAT and (2) to compare the
effectiveness of this 5-HT1A agonist with that of other 5-HT1A agonists and
5-HT1B-preferring agonists. The effects of putative 5-HT1A antagonists
will also be studied. Intact, regularly cycling female rats will be used
and special emphasis will be placed on differentiating the postsynaptic
effects of 8-OH-DPAT will then be infused intracerebrally into the medial
basal hypothalamus and medial preoptic area, terminal fields that control
female reproduction, and into the dorsal raphe nucleus, which contains 5-HT
cell bodies. Sexual behavior will be monitored before and after infusion.
These studies will provide the foundation for future investigations aimed
at identifying the molecular nature and functional consequences of 5-HT1A-
mediated control of sexual behavior.
拟议的研究旨在确定负责的中枢神经系统位点
项目成果
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