TRANSPORT ACROSS ALVEOLAR CAPILLARY MEMBRANE

这项研究计划的主要目的是研究Starling部队。 即(组织压、毛细血管压、组织胶体渗透压、 毛细血管渗透压和淋巴流量)和通透性 肺水肿形成过程中的肺交换血管 由于水力站压力的增加。原位狗肺可以连续 称重动静脉压可以在任何需要的时候控制 水平。还将插入一条小淋巴管来测量流量和 随着毛细血管压力的升高，淋巴蛋白也随之增加。毛细管压力将会是 以5毫米汞的步长升高，毛细管滤过系数，淋巴 蛋白质流量(淋巴流量乘以淋巴蛋白浓度)、组织液 压力(通过植入的胶囊和充满液体的小呼吸道测量)， 毛细血管压力和淋巴和血浆胶体渗透压(使用 膜渗透压计)将在每个新的稳定状态下进行评估 阿龙。肺交换血管的通透性特征可以 在每个压力水平下通过估计反射系数和 淋巴中7种不同蛋白质组分的通透性表面积乘积。 此外，渗透瞬变法将被用作额外的 毛细血管渗透率的估算。 通过结合Starling力变化与毛细血管通透性的分析 测量，我们将能够建立一个更全面的模型 由组胺等其他因素引起的肺水肿， 血清素等。

The major objective of this research proposal is to study the Starling forces i.e., (tissue pressure, capillary pressure, tissue colloid osmotic pressure, capillary osmotic pressure and lymph flow) and the permeability properties of the pulmonary exchange vessels during the formation of pulmonary edema induced by increased hydrostatis pressure. An in situ dog lung can be continuously weighed and arterial and venous pressures can be controlled at any desired level. A small lymphatic vessel will also be cannulated to measure flow and lymph protein as capillary pressure is elevated. Capillary pressure will be elevated in steps of 5 mm Hg and the capillary filtration coefficient, lymphatic protein flux (lymph flow times lymph protein concentration), tissue fluid pressure (as measured by implanted capsules and small fluid filled airways), capillary pressure and lymph and plasma colloid osmotic pressure (measured using a membrane osmometer) will be evaluated at each new steady state obtained by the lung. The permeability characteristics of the pulmonary exchange vessels can be assessed at each pressure level by estimating the reflection coefficient and permeability surface area products of 7 different protein fractions in lymph. In addition, the osmotic transient approach will be used as an additional estimate of capillary permeability. By combining an analysis of Starling forces changes with capillary permeability measurements, we will be able to build a more comprehensive model of the development of pulmonary edema caused by other agents such as histamine, serotonin, etc.