REGULATION OF METABOLISM IN OXYGEN DEFICIENT HEARTS
REGULATION OF METABOLISM IN OXYGEN DEFICIENT HEARTS
批准号:
3335557
负责人:
JAMES R. NEELY
金额:
$17.96万
依托单位国家:
美国
项目类别:
财政年份:
1975
资助国家:
美国
项目状态:
已结题
起止时间:
1975-05-01 至 1986-03-31
关键词:
bioenergetics calcium cardiovascular disorder prevention glycogenolysis glycolysis hydrogen ion transport lactates membrane permeability membrane structure metabolism disorder mitochondria molecular pathology myocardial ischemia /hypoxia myocardium nicotinamide adenine dinucleotide nuclear magnetic resonance spectroscopy oxidative phosphorylation perfusion sarcolemma sarcoplasmic reticulum
中文摘要
心肌缺血时不可逆的细胞损伤机制
将在分离的灌流大鼠心脏中进行研究。初步数据
说明高水平的细胞内糖原分解产物
加速从可逆破坏到不可逆转破坏的转变
与组织高能磷酸盐的变化无关。假设是为了
检测的是糖酵解产物(乳酸、NADH、H+、
等)对冠脉流量和氧化代谢减少的反应
引发一系列的二次反应,最终导致
对组织造成不可逆转的损害。拟议的工作将决定
糖酵解产物组织水平的时间关系
缺血与缺血心脏收缩功能的丧失
随后在好氧条件下再灌流。积累
缺血时的糖酵解产物会因先前的糖原而发生变化。
耗竭、维持不同速度的缺血冠脉血流
缺氧灌流液和糖酵解抑制剂的使用。建议进行研究以
允许识别负责的产品(S)。世俗的
不可逆性损伤的发生与出现的关系
线粒体、肌膜和肌浆网的改变
功能将被确定在暴露于广泛的
糖酵解产物的胞间浓度有助于表征
糖酵解产物引起细胞损伤的机制。这个
这些产品的浓度将一起或单独变化。
糖酵解的抑制剂将被开发出来,试图提供
对缺血心肌的长期保护作用。
英文摘要
The mechanism of irreversible cellular damage during myocardial ischemia
will be investigated in isolated perfused rat hearts. Preliminary data
indicate that high levels of intracellular products of glycogenolysis
accelerate the transition from reversible to irreversible damage
independent of changes in tissue high energy phosphates. The hypothesis to
be tested is that accumulation of glycolytic products (lactate, NADH, H+,
etc.) in response to decreased coronary flow and oxidative metabolism
initiates a series of secondary reactions that ultimately cause
irreversible damage to the tissue. The proposed work will determine the
temporal relation between tissue levels of glycolytic products during
ischemia and the loss of contractile function in ischemic hearts
subsequently reperfused under aerobic conditions. Accumulation of
glycolytic products during ischemia will be varied by prior glycogen
depletion, maintenance of different rates of ischemic coronary flow with
anoxic perfusate and use of glycolytic inhibitors. Studies are proposed to
allow identification of the responsible product(s). The temporal
relationship between onset of irreversible damage and the appearance of
alterations in mitochondrial, sarcolemmal and sarcoplasmic reticular
functions will be determined in ischemic tissue exposed to a wide range of
intercellular concentrations of glycolytic products to help characterize
the mechanisms of glycolytic product induced cellular damage. The
concentration of these products will be varied together and individually.
Inhibitors of glycolysis will be developed in an attempt to provide
prolonged protection to ischemic myocardium.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
DOI:
--
发表时间:
1981-02
期刊:
The American journal of pathology
影响因子:
--
作者:
[J. R. Neely;D. Feuvray]
通讯作者:
J. R. Neely;D. Feuvray
Recovery of ventricular function in reperfused ischemic rat hearts exposed to fatty acids.
暴露于脂肪酸的再灌注缺血大鼠心脏的心室功能恢复。
DOI:
10.1152/ajpheart.1985.249.3.h492
发表时间:
1985
期刊:
The American journal of physiology
影响因子:
--
作者:
[Ichihara,K, Neely,JR]
通讯作者:
Neely,JR
REGULATION OF MYOCARDIAL FATTY ACID METABOLISM
-
批准号:3353886
-
项目类别:
-
资助金额:$9.59万
-
财政年份:1986
-
负责人:JAMES R. NEELY
-
依托单位:
REGULATION OF METABOLISM IN OXYGEN DEFICIENT HEARTS
-
批准号:3353878
-
项目类别:
-
资助金额:$15.53万
-
财政年份:1986
-
负责人:JAMES R. NEELY
-
依托单位:
REGULATION OF METABOLISM IN OXYGEN DEFICIENT HEARTS
-
批准号:3353882
-
项目类别:
-
资助金额:$3.74万
-
财政年份:1986
-
负责人:JAMES R. NEELY
-
依托单位:
REGULATION OF MYOCARDIAL FATTY ACID METABOLISM
-
批准号:3564534
-
项目类别:
-
资助金额:$13.14万
-
财政年份:1986
-
负责人:JAMES R. NEELY
-
依托单位:
REGULATION OF METABOLISM IN OXYGEN DEFICIENT HEARTS
-
批准号:3353879
-
项目类别:
-
资助金额:$19.04万
-
财政年份:1986
-
负责人:JAMES R. NEELY
-
依托单位:
REGULATION OF MYOCARDIAL FATTY ACID METABOLISM
-
批准号:3353884
-
项目类别:
-
资助金额:$13.95万
-
财政年份:1986
-
负责人:JAMES R. NEELY
-
依托单位:
REGULATION OF MYOCARDIAL FATTY ACID METABOLISM
-
批准号:3334562
-
项目类别:
-
资助金额:$14.83万
-
财政年份:1978
-
负责人:JAMES R. NEELY
-
依托单位:
REGULATION OF MYOCARDIAL FATTY ACID METABOLISM
-
批准号:3334563
-
项目类别:
-
资助金额:$3.27万
-
财政年份:1978
-
负责人:JAMES R. NEELY
-
依托单位:
国内基金
海外基金
Calcium/NFAT/GLUT3通路调控糖酵解代谢在CAR-T细胞耗竭中的作用和机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:张明明
-
依托单位:
miR-30调控Calcium/Calcineurin通路在慢性肾脏病心肌保护中的作用
-
批准号:81670699
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2016
-
负责人:郑春霞
-
依托单位:
水稻OsCAS(Calcium-sensing Receptor)基因的功能分析
-
批准号:30900771
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2009
-
负责人:赵昕
-
依托单位: