CONTROL CARDIOVASCULAR AND RENAL EFFECTS OF POTASSIUM

在过去的五年里，我一直在分析控制系统， 调节钾的含量。这一分析将继续，具有以下功能 不同的成分在均匀的条件下分开分析，因此 这些数据可以组合在一起。控制系统的数学模型 已经开发，并将扩展用于开发和测试 假设。短期钾调节的重要因素将是 实验研究包括：1)β-肾上腺素能系统的作用 关于钾素调控，2)钾素调控系统与钾素调控系统的相互作用 胰岛素-血糖调控系统，3)血钾与糖代谢的相互作用 血管紧张素II在醛固酮调节中的作用 影响钾素分配和排泄的因素。 血钾及钾平衡变化对肾功能的影响分析 心血管功能将继续。以下领域将包括 研究：K的持续变化对1)植物的泵吸能力的影响 心脏，2)循环的神经控制，3)血管顺畅的控制 肌肉，4)肾功能，5)血压调节，6)渗透压 调节，以及7)葡萄糖调节。 目前，对钾的调节和调节只有一个初步的了解。 钾浓度异常对主要脏器系统的影响。这个 本文提出的项目结果将提供信息和 对这些领域的了解将改善大型企业的管理 国家医疗保健问题的一部分，包括心脏病， 高血压、糖尿病、手术压力和多种病症 与年老有关的。

For the last five years I have worked to analyze the control system that regulates potassium. This analysis will continue, with the functions of the different components analyzed separately under uniform conditions so that the data may be combined. A mathematical model of the control system has been developed and will be expanded for use in developing and testing hypotheses. Factors important in short-term potassium regulation will be studied experimentally including: 1) effects of the Beta-adrenergic system on K regulation, 2) interaction between the K control system and the insulin-glucose control system, 3) interactions between plasma K and angiotensin II in aldo-sterone regulation, 4) and time courses of action of factors affecting K distribution and excretion. The analysis of effects of changes in plasma K and K balance on renal and cardiovascular function will continue. The following areas will be studied: effects of sustained changes in K on 1) pumping ability of the heart, 2) neural control of the circulation, 3) control of vascular smooth muscle, 4) renal function, 5) blood pressure regulation, 6) osmotic regulation, and 7) glucose regulation. Currently, there is only a rudimentary understanding of K regulation and the effects of abnormal K concentration on the major organ systems. The results of the projects proposed herein will provide information and understanding in these areas which will improve management of a large portion of the health care problems of the nation, including heart disease, hypertension, diabetes mellitus, surgical stress and numerous conditions associated with old age.