The development of catalytic Mitsunobu reactions

催化光延反应的进展

• 批准号: EP/H018034/1
• 负责人: Ross Denton
• 金额: $ 12.72万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH018034%2F1
• 关键词: development; catalytic; Mitsunobu; reactions

One of the major challenges facing chemists and chemical engineers today is the development of clean, energy efficient processes. Inherent in this problem is the necessity to selectively form chemical bonds under environmentally benign conditions. We propose to develop catalysts which will mediate clean, atom efficient versions of a family of chemical reactions used in academic and industrial laboratories worldwide. These reactions currently produce two molecules of waste for every molecule of product generated. In contrast, the only waste product produced by the proposed catalytic chemistry is water. The proposed research will result in cleaner chemical reactions which will be widely used in academic and industrial laboratories and is fundamentally significant to the fields of catalysis and green chemistry.

当今化学家和化学工程师面临的主要挑战之一是开发清洁、节能的工艺。这个问题的本质是需要在环境友好的条件下选择性地形成化学键。我们建议开发催化剂，以介导全球学术和工业实验室使用的一系列化学反应的清洁、原子效率版本。目前，这些反应每产生一分子产物，就会产生两分子废物。相比之下，所提出的催化化学产生的唯一废物是水。拟议的研究将产生更清洁的化学反应，将广泛应用于学术和工业实验室，对催化和绿色化学领域具有根本意义。

项目成果

Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes.

利用氧化膦作为二氧基正膦的前体，开发无氧化还原的 Mitsunobu 反应。

• DOI: 10.1039/c4cc02171a
• 发表时间: 2014
• 期刊: Chemical communications (Cambridge, England)
• 作者: Tang X

Phosphorus(V)-catalyzed deoxydichlorination reactions of aldehydes

• DOI: 10.1016/j.tet.2013.07.100
• 发表时间: 2013-10-14
• 期刊: TETRAHEDRON
• 影响因子: 2.1
• 作者: An, Jie;Tang, Xiaoping;Denton, Ross M.
• 通讯作者: Denton, Ross M.

Phosphonium salt-catalysed synthesis of nitriles from in situ activated oximes

• DOI: 10.1016/j.tet.2012.01.067
• 发表时间: 2012-04-01
• 期刊: TETRAHEDRON
• 影响因子: 2.1
• 作者: Denton, Ross M.;An, Jie;Lewis, William
• 通讯作者: Lewis, William

A procedure for Appel halogenations and dehydrations using a polystyrene supported phosphine oxide

使用聚苯乙烯负载氧化膦进行 Appel 卤化和脱水的方法

• DOI: 10.1016/j.tetlet.2013.11.098
• 发表时间: 2014
• 期刊: Tetrahedron Letters
• 影响因子: 1.8
• 作者: Tang X