PHYSIOLOGICAL PROPERTIES OF A HYPERTENSIVE SUBSTANCE

我们已经制备了一种红细胞溶血产物的提取物， 自发性高血压大鼠，对血压有深远影响 和正常血压动物的血管组织。 这部分产生了一个 高血压大鼠血压升高，可能是 在合同终止后的几天或几周内， 材料的注入。 此外，所涉及的物质刺激 主动脉节段对抗镧钙的体外摄取。 最后，我们观察到，在洗澡时加入这种物质， 介质产生短暂的收缩，然后增加敏感性， 血压正常动物的离体主动脉条。 拟议的一系列研究旨在确定 实质内容。 随后，将进行研究，以确定主要的 以及该物质在完整动物体内的次级作用位点。 在 除了研究对完整动物的影响外，我们还将 表征该物质对收缩性和钙的影响 血管组织的代谢。 本项目获得的信息 将进一步提高我们对高血压和调节的认识， 血压. 它将确定心血管疾病的确切性质 高血压物质引起的变化，并提供洞察 机制。

We have prepared an extract of erythrocyte hemolysates obtained from spontaneously hypertensive rats that has profound effects on blood pressure and vascular tissue of normotensive animals. This fraction produces a hypertensive elevation of blood pressure in normotensive rats that may be maintained for a period of days or weeks beyond the termination of the injection of the material. In addition, the substance involved stimulates the in vitro uptake of lanthanum resistant calcium by aortic segments. Finally, we have observed that the addition of the substance to the bathing media produces a transient contraction followed by increased sensitivity in isolated aortic strips from normotensive animals. The proposed series of studies are to define the hemodynamic effects of the substance. Subsequently, studies will be conducted to determine primary and secondary loci of action of the substance in the intact animal. In addition to the investigation of the effects in the intact animal, we will characterize the influence of the substance on contractility and calcium metabolism of vascular tissue. The information obtained in this project will further our knowledge concerning hypertension and the regulation of blood pressure. It will establish the exact nature of the cardiovascular alterations induced by the hypertensive substance and provide insight into the mechanism.