PHYSIOLOGICAL PROPERTIES OF A HYPERTENSIVE SUBSTANCE
PHYSIOLOGICAL PROPERTIES OF A HYPERTENSIVE SUBSTANCE
批准号:
3345070
负责人:
GARY WRIGHT
金额:
$5.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-04-01 至 1988-03-31
中文摘要
我们从红血球溶血物中提取了一种提取物。
对血压有深远影响的自发性高血压大鼠
以及血压正常的动物的血管组织。这一部分产生了一个
正常血压大鼠的高血压升高,可能是
在合同终止后维持数天或数周的时间
材料的注入。此外,涉及到的物质会刺激
主动脉节段对抗镧钙的体外摄取。
最后,我们观察到,在沐浴中添加这种物质
媒体产生短暂的收缩,然后增加对
正常血压动物的离体主动脉条。
拟议的一系列研究是为了确定血液动力学效应
实质性的。随后,将进行研究,以确定初级
以及该物质在完整动物体内的次要作用部位。在……里面
除了对完好动物的影响进行调查外,我们还将
表征该物质对收缩能力和钙的影响
血管组织的新陈代谢。在这个项目中获得的信息
将进一步加深我们对高血压和高血压调节的认识
血压。它将确定心血管疾病的确切性质
由高血压物质引起的改变,并提供对
这个机制。
英文摘要
We have prepared an extract of erythrocyte hemolysates obtained from
spontaneously hypertensive rats that has profound effects on blood pressure
and vascular tissue of normotensive animals. This fraction produces a
hypertensive elevation of blood pressure in normotensive rats that may be
maintained for a period of days or weeks beyond the termination of the
injection of the material. In addition, the substance involved stimulates
the in vitro uptake of lanthanum resistant calcium by aortic segments.
Finally, we have observed that the addition of the substance to the bathing
media produces a transient contraction followed by increased sensitivity in
isolated aortic strips from normotensive animals.
The proposed series of studies are to define the hemodynamic effects of the
substance. Subsequently, studies will be conducted to determine primary
and secondary loci of action of the substance in the intact animal. In
addition to the investigation of the effects in the intact animal, we will
characterize the influence of the substance on contractility and calcium
metabolism of vascular tissue. The information obtained in this project
will further our knowledge concerning hypertension and the regulation of
blood pressure. It will establish the exact nature of the cardiovascular
alterations induced by the hypertensive substance and provide insight into
the mechanism.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Effect of reduced food intake on blood levels of a hypertensive factor in spontaneously hypertensive rats.
减少食物摄入量对自发性高血压大鼠血液中高血压因子水平的影响。
DOI:
--
发表时间:
1986
期刊:
Journal of hypertension. Supplement : official journal of the International Society of Hypertension
影响因子:
--
作者:
[Wright,GL, McCumbee,WD, Broome,T, Eaton,S]
通讯作者:
Eaton,S
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
-
批准号:7899286
-
项目类别:
-
资助金额:$20.59万
-
财政年份:2009
-
负责人:GARY WRIGHT
-
依托单位:
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
-
批准号:7317075
-
项目类别:
-
资助金额:$32.85万
-
财政年份:2007
-
负责人:GARY WRIGHT
-
依托单位:
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
-
批准号:7671448
-
项目类别:
-
资助金额:$32.14万
-
财政年份:2007
-
负责人:GARY WRIGHT
-
依托单位:
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
-
批准号:7488600
-
项目类别:
-
资助金额:$32.85万
-
财政年份:2007
-
负责人:GARY WRIGHT
-
依托单位:
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
-
批准号:7897905
-
项目类别:
-
资助金额:$32.18万
-
财政年份:2007
-
负责人:GARY WRIGHT
-
依托单位:
Prolyl hydroxylase oxygen sensor in Heart
-
批准号:7030352
-
项目类别:
-
资助金额:$10.55万
-
财政年份:2004
-
负责人:GARY WRIGHT
-
依托单位:
Prolyl hydroxylase oxygen sensor in Heart
-
批准号:6613984
-
项目类别:
-
资助金额:$10.8万
-
财政年份:2004
-
负责人:GARY WRIGHT
-
依托单位:
Prolyl hydroxylase oxygen sensor in Heart
-
批准号:6893440
-
项目类别:
-
资助金额:$10.8万
-
财政年份:2004
-
负责人:GARY WRIGHT
-
依托单位:
PHYSIOLOGICAL PROPERTIES OF A HYPERTENSIVE SUBSTANCE
-
批准号:3345069
-
项目类别:
-
资助金额:$4.79万
-
财政年份:1985
-
负责人:GARY WRIGHT
-
依托单位:
国内基金
海外基金
ITS-HPLC-HRMS-Bioassay多级筛选策略指导下海洋真菌中新型抗菌活性产物的发现
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批准号:41606166
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2016
-
负责人:彭吉星
-
依托单位: