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PHYSIOLOGICAL PROPERTIES OF A HYPERTENSIVE SUBSTANCE

PHYSIOLOGICAL PROPERTIES OF A HYPERTENSIVE SUBSTANCE
高血压物质的生理特性
批准号:
3345070
负责人:
GARY WRIGHT
金额:
$5.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-04-01 至 1988-03-31

项目摘要

项目成果

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中文摘要
翻译
我们已经制备了一种红细胞溶血产物的提取物, 自发性高血压大鼠,对血压有深远影响 和正常血压动物的血管组织。 这部分产生了一个 高血压大鼠血压升高,可能是 在合同终止后的几天或几周内, 材料的注入。 此外,所涉及的物质刺激 主动脉节段对抗镧钙的体外摄取。 最后,我们观察到,在洗澡时加入这种物质, 介质产生短暂的收缩,然后增加敏感性, 血压正常动物的离体主动脉条。 拟议的一系列研究旨在确定 实质内容。 随后,将进行研究,以确定主要的 以及该物质在完整动物体内的次级作用位点。 在 除了研究对完整动物的影响外,我们还将 表征该物质对收缩性和钙的影响 血管组织的代谢。 本项目获得的信息 将进一步提高我们对高血压和调节的认识, 血压. 它将确定心血管疾病的确切性质 高血压物质引起的变化,并提供洞察 机制。
英文摘要
We have prepared an extract of erythrocyte hemolysates obtained from spontaneously hypertensive rats that has profound effects on blood pressure and vascular tissue of normotensive animals. This fraction produces a hypertensive elevation of blood pressure in normotensive rats that may be maintained for a period of days or weeks beyond the termination of the injection of the material. In addition, the substance involved stimulates the in vitro uptake of lanthanum resistant calcium by aortic segments. Finally, we have observed that the addition of the substance to the bathing media produces a transient contraction followed by increased sensitivity in isolated aortic strips from normotensive animals. The proposed series of studies are to define the hemodynamic effects of the substance. Subsequently, studies will be conducted to determine primary and secondary loci of action of the substance in the intact animal. In addition to the investigation of the effects in the intact animal, we will characterize the influence of the substance on contractility and calcium metabolism of vascular tissue. The information obtained in this project will further our knowledge concerning hypertension and the regulation of blood pressure. It will establish the exact nature of the cardiovascular alterations induced by the hypertensive substance and provide insight into the mechanism.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Effect of reduced food intake on blood levels of a hypertensive factor in spontaneously hypertensive rats.
减少食物摄入量对自发性高血压大鼠血液中高血压因子水平的影响。
DOI: --
发表时间: 1986
期刊: Journal of hypertension. Supplement : official journal of the International Society of Hypertension
影响因子: --
作者: [Wright,GL, McCumbee,WD, Broome,T, Eaton,S]
通讯作者: Eaton,S
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
  • 批准号:
    7899286
  • 项目类别:
  • 资助金额:
    $20.59万
  • 财政年份:
    2009
  • 负责人:
    GARY WRIGHT
  • 依托单位:
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
  • 批准号:
    7671448
  • 项目类别:
  • 资助金额:
    $32.14万
  • 财政年份:
    2007
  • 负责人:
    GARY WRIGHT
  • 依托单位:
Role of Prolyl Hydroxylase Oxygen-Sensor in Cardioprotection
国内基金
海外基金
ITS-HPLC-HRMS-Bioassay多级筛选策略指导下海洋真菌中新型抗菌活性产物的发现