PHYSIOLOGICAL PROPERTIES OF A HYPERTENSIVE SUBSTANCE

我们从红血球溶血物中提取了一种提取物。 对血压有深远影响的自发性高血压大鼠 以及血压正常的动物的血管组织。这一部分产生了一个 正常血压大鼠的高血压升高，可能是 在合同终止后维持数天或数周的时间 材料的注入。此外，涉及到的物质会刺激 主动脉节段对抗镧钙的体外摄取。 最后，我们观察到，在沐浴中添加这种物质 媒体产生短暂的收缩，然后增加对 正常血压动物的离体主动脉条。 拟议的一系列研究是为了确定血液动力学效应 实质性的。随后，将进行研究，以确定初级 以及该物质在完整动物体内的次要作用部位。在……里面 除了对完好动物的影响进行调查外，我们还将 表征该物质对收缩能力和钙的影响 血管组织的新陈代谢。在这个项目中获得的信息 将进一步加深我们对高血压和高血压调节的认识 血压。它将确定心血管疾病的确切性质 由高血压物质引起的改变，并提供对 这个机制。

We have prepared an extract of erythrocyte hemolysates obtained from spontaneously hypertensive rats that has profound effects on blood pressure and vascular tissue of normotensive animals. This fraction produces a hypertensive elevation of blood pressure in normotensive rats that may be maintained for a period of days or weeks beyond the termination of the injection of the material. In addition, the substance involved stimulates the in vitro uptake of lanthanum resistant calcium by aortic segments. Finally, we have observed that the addition of the substance to the bathing media produces a transient contraction followed by increased sensitivity in isolated aortic strips from normotensive animals. The proposed series of studies are to define the hemodynamic effects of the substance. Subsequently, studies will be conducted to determine primary and secondary loci of action of the substance in the intact animal. In addition to the investigation of the effects in the intact animal, we will characterize the influence of the substance on contractility and calcium metabolism of vascular tissue. The information obtained in this project will further our knowledge concerning hypertension and the regulation of blood pressure. It will establish the exact nature of the cardiovascular alterations induced by the hypertensive substance and provide insight into the mechanism.