L2M Market Assessment Grant: a bioassay to predict birth timing.

L2M 市场评估补助金：预测出生时间的生物测定。

• 批准号: 571251-2022
• 负责人: Olson, David
• 金额: $ 1.46万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729105
• 关键词: L2M; Market; Assessment; Grant; bioassay

Term delivery in pregnant women occurs over a five-week period from the beginning of the 38th week of gestation to the end of the 42nd week. There are no means to indicate, however, which of these weeks the delivery will actually occur. Our product, a bioassay, is designed to mimic a natural occurrence in the delivery process that determines delivery within 7 days with accuracy >91% and even higher accuracy within 4 days. The principle of the assay is that a chemotactic signal is produced by the fetal membranes (amnion, chorion) surrounding the baby and is released in the final 3-7 days before labour begins. This signal both attracts circulating white blood cells and activates them. The attracted white blood cells will physically migrate into the uterus where they will anchor and then release inflammatory mediators causing the transition from pregnancy to labour and delivery. We can test this with a simple, non-invasive blood draw, which can be obtained at weekly prenatal visits during the final month of pregnancy. Its novelty is it is the only bioassay to assess the timing of birth at term.

孕妇的足月分娩发生在从妊娠第38周开始到第42周结束的五周期间。但是，没有办法表明这几个星期中哪一个星期实际上会交货。我们的产品是一种生物测定法，旨在模拟交付过程中的自然发生，在7天内确定交付，准确度>91%，甚至在4天内更高。该检测的原理是，趋化信号由婴儿周围的胎膜（羊膜、绒毛膜）产生，并在分娩开始前的最后3-7天释放。这种信号既吸引循环的白色血细胞，又激活它们。被吸引的白色血细胞将物理迁移到子宫中，在那里它们将锚，然后释放炎性介质，引起从怀孕到分娩和分娩的过渡。我们可以通过简单的非侵入性抽血来测试这一点，这可以在怀孕最后一个月的每周产前检查中获得。它的新奇在于它是唯一一种评估足月分娩时间的生物测定法。