COORDINATION OF APOLIPOPROTEIN METABOLISM IN MAN
COORDINATION OF APOLIPOPROTEIN METABOLISM IN MAN
批准号:
3340491
负责人:
WALDO R FISHER
金额:
$19.97万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1982
资助国家:
美国
项目状态:
已结题
起止时间:
1982-09-01 至 1990-08-31
关键词:
antihypercholesterolemic agent apolipoproteins blood lipoprotein metabolism blood lipoprotein transport chemical reaction cholesterol cholesterol esters cholestyramine familial hyperlipoproteinemia type II fluorimetry gel electrophoresis high density lipoproteins human subject hypertriglyceridemia leucine lipid metabolism lipid transport lovastatin low density lipoprotein mevalonate molecular pathology phosphatidylcholines radionuclide diagnosis radiotracer secretion triglycerides tritium ultrafiltration very low density lipoprotein
中文摘要
本研究是对以下动力学的持续研究:
人体载脂蛋白代谢。 载脂蛋白是血浆介质
脂质运输,这项调查涉及的关系,
血浆脂质转运和载脂蛋白分泌之间的关系
等离子体
我们的研究有两个基本假设。 1)我们建议
单个载脂蛋白的基质是协调的,
系统功能响应血浆运输的要求,
单个脂质。 因此,我们将测量血浆分泌率
主要载脂蛋白和甘油三酯、胆固醇及其酯
和磷脂,使用生物合成掺入的示踪剂,
H3-亮氨酸、H3-甲羟戊酸和C14-甘油。 正常受试者和患有
选择高脂蛋白血症将在普通饮食下进行研究,
在代谢紊乱后,通过胆固醇喂养,
富含脂肪的饮食,给予消胆胺或Mevinolin。 的
分泌速率常数和血浆转运测定载脂蛋白和
将在这些不同的条件下比较各个脂质,
深入了解载脂蛋白的调控机制
新陈代谢.
2)我们将研究载脂蛋白B的分泌途径,
脂蛋白,以记录分泌途径和
这些脂蛋白的物理异质性。 我们建议,
载脂蛋白B导致含载脂蛋白B内的异质性
分泌沿着途径进入不同的脂蛋白种类,
载脂蛋白B通过单个分泌途径转运量是
这取决于要通过这种方式运输的脂质的量。
载脂蛋白 这一假设将在相同的受试者中进行检验,
测量血浆脂质转运率和apo B分泌到VLDL、IDL中
和低密度脂蛋白亚种。
因此,这些研究将启动对
载脂蛋白的产生和脂质的量之间的关系
用血浆运送
英文摘要
This research is a continuing investigation of the kinetics of
apolipoprotein metabolism in humans. Apolipoproteins are plasma mediators
of lipid transport, and this investigation concerns the relationship
between plasma lipid transport and the secretion of apolipoproteins into
plasma.
Two general hypotheses underlie our studies. 1) We proposed that the
matabolism of the individual apolipoproteins is coordinated and that the
system functions in response to the requirements for plasma transport of
individual lipids. Accordingly we shall measure the plasma secretory rates
for the major apolipoproteins and for triglyceride, cholesterol, its esters
and phospholipid, using biosynthetically incorporated tracers of
H3-leucine, H3-mevalonate and C14-glycerol. Normal subjects and those with
selected hyperlipoproteinemias will be studied on a common diet and again
after metabolic perturbation, by cholesterol feeding, an Omega-3 fatty acid
enriched fat diet, administration of cholestyramine or Mevinolin. The
secretory rate constants and plasma transports measured for apoproteins and
individual lipids will be compared under these various conditions, chosen
to provide insight into control mechanisms regulating apolipoprotein
metabolism.
2) We will examine the pathways for secretion of apo B containing
lipoproteins to document relationships between secretory routes and
physical heterogencity of these lipoproteins. We propose that physical
heterogeneity within the apo B containing lipoproteins results from apo B
secretion along pathways entering different lipoprotein species and that
the magnitude of apo B transport over individual secretory pathways is
determined by the amount of lipid to be transported by this
apolipoprotein. This hypothesis will be examined in the same subjects,
measuring plasma lipid transport rates and apo B secretion into VLDL, IDL
and the fractionated LDL subspecies.
These studies will thus initiate an investigation of the relationship
between apolipoprotein production and the quantity of lipid being
transported in plasma.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
EFFECTS OF ETHANOL ON CARDIOVASCULAR FUNCTION
-
批准号:6246541
-
项目类别:
-
资助金额:$2.51万
-
财政年份:1997
-
负责人:WALDO R FISHER
-
依托单位:
INSULIN SENSITIVITY AND BLOOD PRESSURE IN MEDICAL STUDENTS
-
批准号:6246538
-
项目类别:
-
资助金额:$2.51万
-
财政年份:1997
-
负责人:WALDO R FISHER
-
依托单位:
COORDINATION OF APOLIPOPROTEIN METABOLISM IN MAN
-
批准号:3340493
-
项目类别:
-
资助金额:$20.06万
-
财政年份:1982
-
负责人:WALDO R FISHER
-
依托单位:
COORDINATION OF APOLIPOPROTEIN METABOLISM IN MAN
-
批准号:3340490
-
项目类别:
-
资助金额:$18.66万
-
财政年份:1982
-
负责人:WALDO R FISHER
-
依托单位:
PLASMA LIPID KINETICS IN HYPERCHOLESTROLEMIA
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批准号:3340494
-
项目类别:
-
资助金额:$27.07万
-
财政年份:1982
-
负责人:WALDO R FISHER
-
依托单位:
COORDINATION OF APOLIPOPROTEIN METABOLISM IN MAN
-
批准号:3340488
-
项目类别:
-
资助金额:$20.18万
-
财政年份:1982
-
负责人:WALDO R FISHER
-
依托单位:
COORDINATION OF APOLIPOPROTEIN METABOLISM IN MAN
-
批准号:3340492
-
项目类别:
-
资助金额:$19.42万
-
财政年份:1982
-
负责人:WALDO R FISHER
-
依托单位:
PLASMA LIPID KINETICS IN HYPERCHOLESTROLEMIA
-
批准号:3340489
-
项目类别:
-
资助金额:$27.27万
-
财政年份:1982
-
负责人:WALDO R FISHER
-
依托单位:
PLASMA LIPID KINETICS IN HYPERCHOLESTROLEMIA
-
批准号:2216444
-
项目类别:
-
资助金额:$28.31万
-
财政年份:1982
-
负责人:WALDO R FISHER
-
依托单位:
COMPARISON OF INSULIN SENSITIVITY AMONG MEDICAL STUDENTS
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批准号:3741227
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WALDO R FISHER
-
依托单位:
CORRELATION BETWEEN INTRACELLULAR IONIC CONCENTRATIONS AND BLOOD PRESSURE
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批准号:5219209
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WALDO R FISHER
-
依托单位:--
PLASMA LIPID KINETICS IN HYPERCHOLESTEROLEMIA
-
批准号:3741220
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WALDO R FISHER
-
依托单位:
海外基金