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Development of a Continuous Clean Alkene Epoxidation Process Technology for the Production of Commercially Important Epoxide Building Blocks

开发连续清洁烯烃环氧化工艺技术，用于生产具有商业价值的环氧化物砌块

基本信息

批准号：
EP/H027653/1
负责人：
Basudeb Saha
金额：
$ 13.78万
依托单位：
London South Bank University
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH027653%2F1
关键词：
Development Continuous Clean Alkene Epoxidation

项目摘要

Alkenes (or olefins) are a class of oil-derived hydrocarbons that represent key starting materials for much of the organic chemical industry. A very important step in the conversion of alkenes into molecules that are even more valuable building blocks for the synthesis of a wide variety of products (e.g. pharmaceuticals, plastics, coatings, paints, adhesives, personal products, domestic products and other industrial products) is their selective oxidation to form a new class of molecules called alkene oxides or epoxides. Many of the commercially important procedures for converting alkenes to epoxides employ reagents which are potentially very hazardous, and multi-step processes which by modern standards are of low environmental acceptability. These procedures are also carried out in so-called batch reactions i.e. effectively in a large stirred reactor, with a fixed amount of epoxide being prepared in each batch. Isolating, recovering and purification of the epoxide are additional separate processes involving considerable handling of the product.The work proposed here is aimed at developing a novel process for converting alkenes into their epoxides. The essential features of this have already been demonstrated to be successful and are in the process of being patented. Essentially this involves alternative chemistry to that currently used. It employs an oxidizing agent that is inherently more safe than the currently used agent, and one whose activity needs to be triggered by use of a particular catalyst, adding further to the safety aspects. In addition the process is a continuous rather than a batch one, i.e. the quantity of product generated can be controlled simply by how long the process is allowed to run. This offers the manufacturer significant business flexibility with their customers. The process is also carried out in a special reactor referred to as a Reactive Distillation Column (RDC). In essence this is a vertical tube arrangement with three connected sections. The middle part is a reactor section in which the solid catalyst particles are contained and the chemical reaction takes place, the top and bottom sections are used as separator sections where in effect the epoxide product is isolated. This compact single unit arrangement is extremely convenient and efficient, bringing with it many advantages. It considerably reduces the multi-step handling of the product associated with the existing processes, the 'footprint' and complexity of all the apparatus is reduced, and the ability to switch from one alkene feedstock to a completely different one is considerably facilitated. As a bonus the organic by-product from the oxidizing agent is itself a useful chemical building block and so overall the efficiency of use of all the organic chemical species (referred to by chemists as the 'atom efficiency') is very high.Overall therefore this new process provides many advantages to potential users: feedstock flexibility, 'atom efficiency', flexibility of scale of production, reduced unit costs and improved profitability. Importantly as well, the new process makes a big impact on the environmental acceptability of epoxide production.

烯烃（或烯烃）是一类石油衍生的碳氢化合物，代表了许多有机化学工业的关键起始材料。在将烯烃转化为对于合成各种各样的产品（例如药物、塑料、涂料、油漆、粘合剂、个人产品、家用产品和其他工业产品）甚至更有价值的结构单元的分子中的一个非常重要的步骤是它们的选择性氧化以形成称为烯烃氧化物或环氧化物的一类新分子。许多将烯烃转化为环氧化物的商业上重要的方法使用了潜在地非常危险的试剂，并且使用了按照现代标准具有低环境可接受性的多步方法。这些程序也在所谓的间歇反应中进行，即在大型搅拌反应器中有效地进行，其中在每批中制备固定量的环氧化物。环氧化物的分离、回收和纯化是另外的独立过程，涉及相当多的产物处理。本文提出的工作旨在开发一种将烯烃转化为环氧化物的新方法。其基本功能已经被证明是成功的，并正在申请专利。基本上，这涉及到目前使用的替代化学。它采用的氧化剂本质上比目前使用的试剂更安全，并且其活性需要通过使用特定的催化剂来触发，进一步增加了安全性。此外，该过程是连续的而不是分批的，即，可以简单地通过允许该过程运行多长时间来控制所产生的产品的量。这为制造商提供了与客户的显著业务灵活性。该过程也在称为反应蒸馏塔（RDC）的特殊反应器中进行。本质上，这是具有三个连接部分的垂直管布置。中间部分是反应器部分，其中包含固体催化剂颗粒并发生化学反应，顶部和底部部分用作分离器部分，实际上将环氧化物产物分离出来。这种紧凑的单个单元布置非常方便和高效，带来了许多优点。它大大减少了与现有方法相关的产物的多步处理，减少了所有设备的“占地面积”和复杂性，并且大大促进了从一种烯烃原料转换为完全不同的烯烃原料的能力。额外的好处是，氧化剂的有机副产物本身就是一种有用的化学结构单元，因此所有有机化学物质的总体使用效率（化学家称之为“原子效率”）非常高。因此，这种新工艺为潜在用户提供了许多优势：原料灵活性、“原子效率”、生产规模灵活性、单位成本降低和盈利能力提高。同样重要的是，新工艺对环氧化物生产的环境可接受性产生了重大影响。