BRAIN MICROCIRCULATION, PLATELETS, AND SEX HORMONES

大脑表面的小动脉和小静脉将受到损伤， 颈动脉将被损伤，花生四烯酸将被注入 颈动脉。这三种技术将导致血小板聚集 出现在脑血管中，这将在活着的动物身上进行监测 (小鼠)通过直接观察大脑表面血管 显微镜和脑(大鼠、小鼠)的组织学研究。这 研究重点是性别和性激素对健康的影响 脑血管直接损伤后的聚集性和聚集体 由注射花生四烯酸产生，或作为栓子从受伤的 颈动脉。聚集的延迟、聚集或血管的数量 由聚集体参与，将受到监控。性别或性别的影响 体内的荷尔蒙将与和/或与 这些变量对体外血小板聚集性和生产的影响 由血管壁组成的反聚集材料。性别和性别对儿童心理健康的影响 对抗聚集药物的反应也将被确定。这个 脑血管的反应将与肠系膜的反应进行比较。 或者是肾血管床。这些研究将提供与 目前关于艾滋病有害影响的文献相互矛盾 在全部或部分依赖的疾病中，男性或女性激素 血小板聚集。这些疾病中有短暂性脑缺血 袭击。这些数据也将与优惠问题有关。 阿司匹林等抗血小板治疗对男性有益。

The arterioles and venules on the cerebral surface will be injured, the carotid artery will be injured, and arachidonate will be infused into the carotid artery. These 3 techniques will result in platelet aggregates appearing in cerebral vessels, and this will be monitored in living animals (mice) by direct observation of cerebral surface vessels via the microscope, and by histologic study of the brain (rats, mice). This investigation focusses on the influence of gender and sex hormones on aggregation in the directly injured cerebral vessels and on aggregates produced by injected arachidonate, or arising as emboli from an injured carotid. The latency of aggregation, the numbers of aggregates or vessels involved by aggregates, will be monitored. The effect of gender or hormones in vivo will be compared with and/or related to the influence of these variables on platelet aggregability in vitro and on the production of antiaggregant materials by vessel wall. The effect of gender and sex on the response to antiaggregatory drugs will also be determined. The responses of cerebral vessels will be compared with that of the mesentery or the renal vascular bed. The studies will provide data relevant to the presently contradictory literature concerning the detrimental effect of either male or female hormones in diseases dependent in whole or part, upon platelet aggregation. Among these diseases are transient ischemic attacks. The data will also be relevant to the question of preferential benefit in males, of antiplatelet therapies such as aspirin.