THE CONTACT SYSTEM IN ALLERGIC ASTHMA

在拟议的研究中，我们将检查联系的关系 (Hageman因子)系统与诱发支气管痉挛的发生 哮喘、过敏性和非过敏性支气管炎患者。证据 已经获得，表明可以通过以下方式激活接触系统 体外和体内的过敏反应。拟议的研究将 阐明过敏反应与神经递质激活之间的关系 采用最新开发方法的联系人系统 敏锐地提供清晰的数据。我们将比较关于激活的数据 接触(缓激肽形成)系统与白三烯C和D水平 在支气管肺泡灌洗液中。这将被执行，因为 已知的缓激肽对花生四烯酸系统的刺激。其他研究 旨在了解过敏症的发病机制和 非过敏性支气管炎。游离弹性蛋白酶和氧化的α-1-PI 在初诊支气管炎患者的灌洗液中发现 学习。我们将进一步探讨这些与炎症的关系。 肺部疾病。

In the proposed studies we will examine the relationship of the contact (Hageman factor) system and the development of provoked bronchospasm in patients with asthma and allergic and non-allergic bronchitis. Evidence has been obtained indicating that the contact system can be activated by allergic reactions both in vitro and in vivo. The proposed studies will clarify the relationship between allergic reactions and activation of the contact system employing recently development methods that are sufficiently sensitive to provide clear data. We will compare data on the activation of the contact (bradykinin-forming) system and levels of leukotriene C and D in bronchoalveolar lavage fluid. This will be performed because of the known stimulation of the arachidonate system by bradykinin. Other studies are directed toward understanding the pathogenesis of allergic and non-allergic bronchitis. Free elastase and oxidized alpha-1-PI have been found in lavage fluids from patients with bronchitis in preliminary studies. We will further explore the relationship of these to inflammatory pulmonary disease.