The effect of wastewater treatment on the ecotoxicity of chiral chemicals

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This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically toxic species. This project will investigate why and how some pharmaceuticals become susceptible to chiral inversion and assess ecotoxicological differences. This work is expected to determine the significance of considering chiral inversion in environmental risk assessment, with applications to a broader range of chemicals including pesticides and industrial chemicals.