The effect of wastewater treatment on the ecotoxicity of chiral chemicals

废水处理对手性化学品生态毒性的影响

• 批准号: DP170100357
• 负责人: Prof Stuart Khan
• 金额: $ 26.23万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100357
• 关键词: effect; wastewater; treatment; ecotoxicity; chiral

This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically toxic species. This project will investigate why and how some pharmaceuticals become susceptible to chiral inversion and assess ecotoxicological differences. This work is expected to determine the significance of considering chiral inversion in environmental risk assessment, with applications to a broader range of chemicals including pesticides and industrial chemicals.

该项目旨在评估废水处理厂废水中排放的药物对环境的影响。污水和城市水道中存在微量的人类药物，但在污水处理过程中，一些药物可能会发生称为“手性反转”的化学转化。在某些情况下，这可能会将相对良性的环境污染物转化为生态毒性更大的物种。该项目将研究某些药物为何以及如何容易受到手性反转的影响，并评估生态毒理学差异。这项工作预计将确定在环境风险评估中考虑手性反转的重要性，并应用于更广泛的化学品，包括农药和工业化学品。