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A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities

一种新型机器人废水分析系统，用于量化住宅社区中阿片类药物的暴露和处理

基本信息

批准号：
10549579
负责人：
Peter R Chai
金额：
$ 17.49万
依托单位：
BIOBOT ANALYTICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10549579
关键词：
2019-nCoV Accident and Emergency department Address Administrative Supplement American Area Back Behavior Therapy Benchmarking Biological Biological Assay Biological Markers Businesses COVID-19 COVID-19 assay COVID-19 surveillance Caring Catchment Area Chemicals Chronic Cities Clinic Clinical Cocaine Collection Communities Consumption Counseling Cross-Sectional Studies Data Detection Development Drug Screening Drug usage Emergency medical service Glucuronides HIV Infections Harm Reduction High Pressure Liquid Chromatography Hospitals Human Individual Infrastructure Intervention Journals Ketamine Life Link Location Mass Spectrum Analysis Massachusetts Measures Medical Mental Health Methamphetamine Methamphetamine use disorder Methods Mission Morbidity - disease rate Municipalities Naloxone Neighborhoods Opioid Parents Pathway interactions Patient Self-Report Pharmaceutical Preparations Pharmacologic Substance Pharmacotherapy Pharmacy facility Phencyclidine Plants Population Positioning Attribute Precision Health Preparation Prevalence Psychiatric therapeutic procedure Public Health Public Policy Recovery Reporting Resource Allocation Robotics Sampling Screening Result Sewage Site Small Business Innovation Research Grant Substance Use Disorder Surveillance Program Surveys System Systems Analysis Techniques Time Toxic effect Toxicology Trauma United States Urine Validation Vulnerable Populations Water Work base comorbidity data visualization drug development effective intervention effective therapy endo-alpha-sialidase health care service utilization high risk injection drug use innovation insight instrument interest medical schools medication nonadherence mortality multidisciplinary novel opioid epidemic opioid exposure opioid use disorder outreach parent grant peer population health prescription opioid prescription stimulants programs psychostimulant public health priorities public health relevance response sample collection stimulant use stimulant use disorder stimulant user substance use success surveillance data surveillance strategy trend wastewater epidemiology wastewater samples wastewater surveillance

项目摘要

ABSTRACT. Illicit psychostimulant use is increasing across the United States leading to significant morbidity and mortality. A 2019 cross sectional study found that individuals with self reported methamphetamine use disorder in the US has tripled since 2015. The downstream comorbidities associated with methamphetamine and other psychostimulants like cocaine, ketamine and phencyclidine result in increased healthcare utilization, medication nonadherence, infectious complications of drug use, and worsening mental health and trauma. Despite its importance, surveillance of psychostimulant use remains suboptimal; most existing surveillance strategies utilize large national self-report sampling or data from emergency department and substance use disorder clinic urine drug screens resulting in significant bias. This surveillance data is utilized to inform national public health priorities and on a community scale, allocation of resources to address substance use disorders. Wastewater-based epidemiology is a potential option to conduct population level drug surveillance. By measuring key parent compound and metabolites in wastewater networks, a prevalence estimate of drug use and trends of use over time can be visualized. By varying the location of sample collection in the wastewater network, substance use data can be described at a large wastewater treatment plant catchment area or at the community level by measuring substances at individual street level manholes. Our ongoing fast track SBIR leverages wastewater networks to develop and commercialize an opioid assay that measures both parent opioids as well as key metabolites that indicate consumption. This administrative supplement iterates on our successful parent grant by selecting four psychostimulants of

摘要。在美国，非法使用精神兴奋剂的情况日益增多，导致发病率和死亡率显著上升。一 2019年的横断面研究发现，美国自我报告甲基苯丙胺使用障碍的个人自2015年以来增长了两倍。与甲基苯丙胺和其他药物相关的下游共病可卡因、氯胺酮和苯环己哌啶等精神兴奋剂导致医疗保健利用增加，药物不依从性、药物使用的感染性并发症以及精神健康和创伤恶化。尽管其重要性，精神兴奋剂使用的监测仍然是次优;大多数现有的监测战略利用大规模的国家自我报告抽样或来自急诊科和药物使用的数据疾病临床尿液药物筛查导致显著偏倚。这些监测数据用于告知国家公共卫生优先事项和社区一级的资源分配，以解决药物使用问题紊乱以水为基础的流行病学是进行人口一级药物监测的一个潜在选择。通过测量废水网络中的关键母体化合物和代谢物，使用情况和使用趋势随时间的变化可以可视化。通过改变样品收集在废水网络，物质使用数据可以在一个大型废水处理厂集水区描述通过测量街道沙井中的物质，在区域或社区一级进行监测。我们正在进行的快速 track SBIR利用废水网络开发并商业化阿片类药物检测，母体阿片类药物以及指示消费的关键代谢物。此管理补充迭代于我们成功的父母补助金，通过选择四种精神兴奋剂，

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of Chemical, Biological, Radiological, Nuclear, Explosives (CBRNE) Knowledge Change and Skills Confidence Among Frontline-Line Providers During the Russia-Ukraine War.

DOI：
10.1017/dmp.2023.52
发表时间：
2023-05-09
期刊：
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
影响因子：
2.7
作者：
Erickson, Timothy B.;Harvin, Donell;Schmid, Alexis;Loevinsohn, Gideon;Poriechna, Anna;Martyshyn, Oleg;Kliukach, Kryrylo;Sydlowski, Meaghan;Strong, Jonathan;Kivlehan, Sean M.
通讯作者：
Kivlehan, Sean M.

Human trafficking and the growing malady of disinformation.