A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
基本信息
- 批准号:10549579
- 负责人:
- 金额:$ 17.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAccident and Emergency departmentAddressAdministrative SupplementAmericanAreaBackBehavior TherapyBenchmarkingBiologicalBiological AssayBiological MarkersBusinessesCOVID-19COVID-19 assayCOVID-19 surveillanceCaringCatchment AreaChemicalsChronicCitiesClinicClinicalCocaineCollectionCommunitiesConsumptionCounselingCross-Sectional StudiesDataDetectionDevelopmentDrug ScreeningDrug usageEmergency medical serviceGlucuronidesHIV InfectionsHarm ReductionHigh Pressure Liquid ChromatographyHospitalsHumanIndividualInfrastructureInterventionJournalsKetamineLifeLinkLocationMass Spectrum AnalysisMassachusettsMeasuresMedicalMental HealthMethamphetamineMethamphetamine use disorderMethodsMissionMorbidity - disease rateMunicipalitiesNaloxoneNeighborhoodsOpioidParentsPathway interactionsPatient Self-ReportPharmaceutical PreparationsPharmacologic SubstancePharmacotherapyPharmacy facilityPhencyclidinePlantsPopulationPositioning AttributePrecision HealthPreparationPrevalencePsychiatric therapeutic procedurePublic HealthPublic PolicyRecoveryReportingResource AllocationRoboticsSamplingScreening ResultSewageSiteSmall Business Innovation Research GrantSubstance Use DisorderSurveillance ProgramSurveysSystemSystems AnalysisTechniquesTimeToxic effectToxicologyTraumaUnited StatesUrineValidationVulnerable PopulationsWaterWorkbasecomorbiditydata visualizationdrug developmenteffective interventioneffective therapyendo-alpha-sialidasehealth care service utilizationhigh riskinjection drug useinnovationinsightinstrumentinterestmedical schoolsmedication nonadherencemortalitymultidisciplinarynovelopioid epidemicopioid exposureopioid use disorderoutreachparent grantpeerpopulation healthprescription opioidprescription stimulantsprogramspsychostimulantpublic health prioritiespublic health relevanceresponsesample collectionstimulant usestimulant use disorderstimulant usersubstance usesuccesssurveillance datasurveillance strategytrendwastewater epidemiologywastewater sampleswastewater surveillance
项目摘要
ABSTRACT.
Illicit psychostimulant use is increasing across the United States leading to significant morbidity and mortality. A
2019 cross sectional study found that individuals with self reported methamphetamine use disorder in the US
has tripled since 2015. The downstream comorbidities associated with methamphetamine and other
psychostimulants like cocaine, ketamine and phencyclidine result in increased healthcare utilization,
medication nonadherence, infectious complications of drug use, and worsening mental health and trauma.
Despite its importance, surveillance of psychostimulant use remains suboptimal; most existing surveillance
strategies utilize large national self-report sampling or data from emergency department and substance use
disorder clinic urine drug screens resulting in significant bias. This surveillance data is utilized to inform
national public health priorities and on a community scale, allocation of resources to address substance use
disorders. Wastewater-based epidemiology is a potential option to conduct population level drug surveillance.
By measuring key parent compound and metabolites in wastewater networks, a prevalence estimate of drug
use and trends of use over time can be visualized. By varying the location of sample collection in the
wastewater network, substance use data can be described at a large wastewater treatment plant catchment
area or at the community level by measuring substances at individual street level manholes. Our ongoing fast
track SBIR leverages wastewater networks to develop and commercialize an opioid assay that measures both
parent opioids as well as key metabolites that indicate consumption. This administrative supplement iterates on
our successful parent grant by selecting four psychostimulants of
摘要。
在美国,非法使用精神兴奋剂的情况日益增多,导致发病率和死亡率显著上升。一
2019年的横断面研究发现,美国自我报告甲基苯丙胺使用障碍的个人
自2015年以来增长了两倍。与甲基苯丙胺和其他药物相关的下游共病
可卡因、氯胺酮和苯环己哌啶等精神兴奋剂导致医疗保健利用增加,
药物不依从性、药物使用的感染性并发症以及精神健康和创伤恶化。
尽管其重要性,精神兴奋剂使用的监测仍然是次优;大多数现有的监测
战略利用大规模的国家自我报告抽样或来自急诊科和药物使用的数据
疾病临床尿液药物筛查导致显著偏倚。这些监测数据用于告知
国家公共卫生优先事项和社区一级的资源分配,以解决药物使用问题
紊乱以水为基础的流行病学是进行人口一级药物监测的一个潜在选择。
通过测量废水网络中的关键母体化合物和代谢物,
使用情况和使用趋势随时间的变化可以可视化。通过改变样品收集在
废水网络,物质使用数据可以在一个大型废水处理厂集水区描述
通过测量街道沙井中的物质,在区域或社区一级进行监测。我们正在进行的快速
track SBIR利用废水网络开发并商业化阿片类药物检测,
母体阿片类药物以及指示消费的关键代谢物。此管理补充迭代于
我们成功的父母补助金,通过选择四种精神兴奋剂,
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluation of Chemical, Biological, Radiological, Nuclear, Explosives (CBRNE) Knowledge Change and Skills Confidence Among Frontline-Line Providers During the Russia-Ukraine War.
- DOI:10.1017/dmp.2023.52
- 发表时间:2023-05-09
- 期刊:
- 影响因子:2.7
- 作者:Erickson, Timothy B.;Harvin, Donell;Schmid, Alexis;Loevinsohn, Gideon;Poriechna, Anna;Martyshyn, Oleg;Kliukach, Kryrylo;Sydlowski, Meaghan;Strong, Jonathan;Kivlehan, Sean M.
- 通讯作者:Kivlehan, Sean M.
Human trafficking and the growing malady of disinformation.
- DOI:10.3389/fpubh.2022.987159
- 发表时间:2022
- 期刊:
- 影响因子:5.2
- 作者:Prakash, Jaya;Erickson, Timothy B.;Stoklosa, Hanni
- 通讯作者:Stoklosa, Hanni
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Peter R Chai其他文献
Advising Around Cannabis for Sleep: Clearing Up the Smoke
关于大麻睡眠的建议:清除烟雾
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Stephanie Tung;Peter R Chai;M. Nayak;Ilana M Braun - 通讯作者:
Ilana M Braun
Peter R Chai的其他文献
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{{ truncateString('Peter R Chai', 18)}}的其他基金
Ketamine for the treatment for opioid use disorder and suicidal ideation in the emergency department
氯胺酮用于治疗急诊科阿片类药物使用障碍和自杀意念
- 批准号:
10646993 - 财政年份:2023
- 资助金额:
$ 17.49万 - 项目类别:
Ketamine for the treatment for alcohol use disorder in the emergency department: A pilot double-blind, placebo-controlled randomized clinical trial
氯胺酮在急诊科治疗酒精使用障碍:一项双盲、安慰剂对照随机临床试验
- 批准号:
10593244 - 财政年份:2022
- 资助金额:
$ 17.49万 - 项目类别:
Smart Steps: A context-aware adherence intervention to improve PrEP adherence among men who have sex with men (MSM) with substance use disorder
明智的步骤:情境感知的依从性干预措施可提高患有物质使用障碍的男男性行为者 (MSM) 的 PrEP 依从性
- 批准号:
10468388 - 财政年份:2022
- 资助金额:
$ 17.49万 - 项目类别:
Ketamine for the treatment for alcohol use disorder in the emergency department: A pilot double-blind, placebo-controlled randomized clinical trial
氯胺酮在急诊科治疗酒精使用障碍:一项试点双盲、安慰剂对照随机临床试验
- 批准号:
10703512 - 财政年份:2022
- 资助金额:
$ 17.49万 - 项目类别:
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
- 批准号:
10313450 - 财政年份:2020
- 资助金额:
$ 17.49万 - 项目类别:
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
- 批准号:
10328984 - 财政年份:2020
- 资助金额:
$ 17.49万 - 项目类别:
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
- 批准号:
10381304 - 财政年份:2020
- 资助金额:
$ 17.49万 - 项目类别:
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users
开发可摄入生物传感器以增强药物使用者的 PrEP 依从性
- 批准号:
10401432 - 财政年份:2018
- 资助金额:
$ 17.49万 - 项目类别:
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users
开发可摄入生物传感器以增强药物使用者的 PrEP 依从性
- 批准号:
9924467 - 财政年份:2018
- 资助金额:
$ 17.49万 - 项目类别:
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users
开发可摄入生物传感器以增强药物使用者的 PrEP 依从性
- 批准号:
10674107 - 财政年份:2018
- 资助金额:
$ 17.49万 - 项目类别: