A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
基本信息
- 批准号:10549579
- 负责人:
- 金额:$ 17.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAccident and Emergency departmentAddressAdministrative SupplementAmericanAreaBackBehavior TherapyBenchmarkingBiologicalBiological AssayBiological MarkersBusinessesCOVID-19COVID-19 assayCOVID-19 surveillanceCaringCatchment AreaChemicalsChronicCitiesClinicClinicalCocaineCollectionCommunitiesConsumptionCounselingCross-Sectional StudiesDataDetectionDevelopmentDrug ScreeningDrug usageEmergency medical serviceGlucuronidesHIV InfectionsHarm ReductionHigh Pressure Liquid ChromatographyHospitalsHumanIndividualInfrastructureInterventionJournalsKetamineLifeLinkLocationMass Spectrum AnalysisMassachusettsMeasuresMedicalMental HealthMethamphetamineMethamphetamine use disorderMethodsMissionMorbidity - disease rateMunicipalitiesNaloxoneNeighborhoodsOpioidParentsPathway interactionsPatient Self-ReportPharmaceutical PreparationsPharmacologic SubstancePharmacotherapyPharmacy facilityPhencyclidinePlantsPopulationPositioning AttributePrecision HealthPreparationPrevalencePsychiatric therapeutic procedurePublic HealthPublic PolicyRecoveryReportingResource AllocationRoboticsSamplingScreening ResultSewageSiteSmall Business Innovation Research GrantSubstance Use DisorderSurveillance ProgramSurveysSystemSystems AnalysisTechniquesTimeToxic effectToxicologyTraumaUnited StatesUrineValidationVulnerable PopulationsWaterWorkbasecomorbiditydata visualizationdrug developmenteffective interventioneffective therapyendo-alpha-sialidasehealth care service utilizationhigh riskinjection drug useinnovationinsightinstrumentinterestmedical schoolsmedication nonadherencemortalitymultidisciplinarynovelopioid epidemicopioid exposureopioid use disorderoutreachparent grantpeerpopulation healthprescription opioidprescription stimulantsprogramspsychostimulantpublic health prioritiespublic health relevanceresponsesample collectionstimulant usestimulant use disorderstimulant usersubstance usesuccesssurveillance datasurveillance strategytrendwastewater epidemiologywastewater sampleswastewater surveillance
项目摘要
ABSTRACT.
Illicit psychostimulant use is increasing across the United States leading to significant morbidity and mortality. A
2019 cross sectional study found that individuals with self reported methamphetamine use disorder in the US
has tripled since 2015. The downstream comorbidities associated with methamphetamine and other
psychostimulants like cocaine, ketamine and phencyclidine result in increased healthcare utilization,
medication nonadherence, infectious complications of drug use, and worsening mental health and trauma.
Despite its importance, surveillance of psychostimulant use remains suboptimal; most existing surveillance
strategies utilize large national self-report sampling or data from emergency department and substance use
disorder clinic urine drug screens resulting in significant bias. This surveillance data is utilized to inform
national public health priorities and on a community scale, allocation of resources to address substance use
disorders. Wastewater-based epidemiology is a potential option to conduct population level drug surveillance.
By measuring key parent compound and metabolites in wastewater networks, a prevalence estimate of drug
use and trends of use over time can be visualized. By varying the location of sample collection in the
wastewater network, substance use data can be described at a large wastewater treatment plant catchment
area or at the community level by measuring substances at individual street level manholes. Our ongoing fast
track SBIR leverages wastewater networks to develop and commercialize an opioid assay that measures both
parent opioids as well as key metabolites that indicate consumption. This administrative supplement iterates on
our successful parent grant by selecting four psychostimulants of
摘要。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluation of Chemical, Biological, Radiological, Nuclear, Explosives (CBRNE) Knowledge Change and Skills Confidence Among Frontline-Line Providers During the Russia-Ukraine War.
- DOI:10.1017/dmp.2023.52
- 发表时间:2023-05-09
- 期刊:
- 影响因子:2.7
- 作者:Erickson, Timothy B.;Harvin, Donell;Schmid, Alexis;Loevinsohn, Gideon;Poriechna, Anna;Martyshyn, Oleg;Kliukach, Kryrylo;Sydlowski, Meaghan;Strong, Jonathan;Kivlehan, Sean M.
- 通讯作者:Kivlehan, Sean M.
Human trafficking and the growing malady of disinformation.
- DOI:10.3389/fpubh.2022.987159
- 发表时间:2022
- 期刊:
- 影响因子:5.2
- 作者:Prakash, Jaya;Erickson, Timothy B.;Stoklosa, Hanni
- 通讯作者:Stoklosa, Hanni
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Peter R Chai其他文献
Advising Around Cannabis for Sleep: Clearing Up the Smoke
关于大麻睡眠的建议:清除烟雾
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Stephanie Tung;Peter R Chai;M. Nayak;Ilana M Braun - 通讯作者:
Ilana M Braun
Peter R Chai的其他文献
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{{ truncateString('Peter R Chai', 18)}}的其他基金
Ketamine for the treatment for opioid use disorder and suicidal ideation in the emergency department
氯胺酮用于治疗急诊科阿片类药物使用障碍和自杀意念
- 批准号:
10646993 - 财政年份:2023
- 资助金额:
$ 17.49万 - 项目类别:
Ketamine for the treatment for alcohol use disorder in the emergency department: A pilot double-blind, placebo-controlled randomized clinical trial
氯胺酮在急诊科治疗酒精使用障碍:一项双盲、安慰剂对照随机临床试验
- 批准号:
10593244 - 财政年份:2022
- 资助金额:
$ 17.49万 - 项目类别:
Smart Steps: A context-aware adherence intervention to improve PrEP adherence among men who have sex with men (MSM) with substance use disorder
明智的步骤:情境感知的依从性干预措施可提高患有物质使用障碍的男男性行为者 (MSM) 的 PrEP 依从性
- 批准号:
10468388 - 财政年份:2022
- 资助金额:
$ 17.49万 - 项目类别:
Ketamine for the treatment for alcohol use disorder in the emergency department: A pilot double-blind, placebo-controlled randomized clinical trial
氯胺酮在急诊科治疗酒精使用障碍:一项试点双盲、安慰剂对照随机临床试验
- 批准号:
10703512 - 财政年份:2022
- 资助金额:
$ 17.49万 - 项目类别:
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
- 批准号:
10313450 - 财政年份:2020
- 资助金额:
$ 17.49万 - 项目类别:
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
- 批准号:
10328984 - 财政年份:2020
- 资助金额:
$ 17.49万 - 项目类别:
A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
一种新型机器人废水分析系统,用于量化住宅社区中阿片类药物的暴露和处理
- 批准号:
10381304 - 财政年份:2020
- 资助金额:
$ 17.49万 - 项目类别:
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users
开发可摄入生物传感器以增强药物使用者的 PrEP 依从性
- 批准号:
10401432 - 财政年份:2018
- 资助金额:
$ 17.49万 - 项目类别:
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users
开发可摄入生物传感器以增强药物使用者的 PrEP 依从性
- 批准号:
9924467 - 财政年份:2018
- 资助金额:
$ 17.49万 - 项目类别:
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users
开发可摄入生物传感器以增强药物使用者的 PrEP 依从性
- 批准号:
10674107 - 财政年份:2018
- 资助金额:
$ 17.49万 - 项目类别: