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Nanostructures confined in micro- and nano-cavities: Direct measurement of consequent surface forces

限制在微米和纳米腔中的纳米结构：直接测量随之产生的表面力

基本信息

批准号：
EP/H034862/1
负责人：
Wuge Briscoe
金额：
$ 13.57万
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH034862%2F1
关键词：
Nanostructures confined micro nano cavities

项目摘要

From moving cartilages in a mammalian joint, to dispersed pigment particles in household paint, the situations where surfaces come to close proximity are ubiquitous. The interactions between these surfaces (called surface forces) are critical in achieving desirable material properties and facilitating designed technological processes, and underpin many natural and biological phenomena. With the rapid development of nanotechnology, the surface-to-volume ratio ever grows and so does the importance of surface interactions. Given such importance, much effort has been dedicated to improving our understanding of surface forces, both theoretically and experimentally. As a result, we have plenty of tricks up our sleeves to arrange and modify surface forces to facilitate different applications or material properties. These tricks most notably include adjusting solution conditions, such as electrolyte concentrations, in order to control the electric double layer force, and adding soft condensed matter (polymers and surfactants) to the surface and the intervening medium. Thanks to a steady drive towards smaller and smaller structures in modern technologies, we increasingly find nanostructures (or nanoparticles) of different materials, sizes and shapes added as an ingredient to our product formulations, particularly in personal care products and biomedical applications, in order to achieve desirable material properties or to preform a particular function. There are clear indications that the effective roles of nanostructures in these applications have much to do with how they interact with various surfaces and how they mediate surface forces between macroscopic surfaces. Many promising biomedical and bioanalytical applications of nanoparticles also exploit their interactions with complex biological tissue surfaces embedded with biopolymers and lipids. However, there is a public perception, correctly so, that we don't fully understand the impact of nanostructures on our health and environment. We can improve that understanding on different levels. In this project, we propose to perform a series of measurements of surface forces mediated by nanostructures, to comprehensively probe the effects of a range of parameters such as the size, shape and surface chemistry of the nanostructures on surface forces they mediate. This will improve our understanding on a fundamental level of how nanostructures facilitate surface interactions, and such knowledge will help us to harness nanostructures' full potential in modern technologies and medical applications.

从哺乳动物关节中移动的软骨，到家用油漆中分散的颜料颗粒，表面非常接近的情况无处不在。这些表面之间的相互作用（称为表面力）对于实现理想的材料性能和促进设计的技术过程至关重要，并且是许多自然和生物现象的基础。随着纳米技术的快速发展，表面与体积之比不断增长，表面相互作用的重要性也随之增加。鉴于如此重要，我们在理论上和实验上都致力于提高我们对表面力的理解。因此，我们有很多技巧来安排和修改表面力，以促进不同的应用或材料特性。这些技巧最值得注意的是包括调整溶液条件，例如电解质浓度，以控制双电层力，以及向表面和中间介质添加软凝聚态物质（聚合物和表面活性剂）。由于现代技术不断朝着越来越小的结构发展，我们越来越多地发现不同材料、尺寸和形状的纳米结构（或纳米颗粒）作为成分添加到我们的产品配方中，特别是在个人护理产品和生物医学应用中，以实现理想的材料性能或执行特定功能。有明确的迹象表明，纳米结构在这些应用中的有效作用与它们如何与各种表面相互作用以及它们如何调节宏观表面之间的表面力有很大关系。纳米粒子的许多有前途的生物医学和生物分析应用也利用了它们与嵌入生物聚合物和脂质的复杂生物组织表面的相互作用。然而，公众有一种正确的看法，即我们并不完全了解纳米结构对我们的健康和环境的影响。我们可以在不同层面上提高这种理解。在这个项目中，我们建议对纳米结构介导的表面力进行一系列测量，以全面探讨纳米结构的尺寸、形状和表面化学等一系列参数对其介导的表面力的影响。这将提高我们对纳米结构如何促进表面相互作用的基本理解，并且这些知识将帮助我们充分利用纳米结构在现代技术和医疗应用中的潜力。