Directed Assembly of Extended Structures with Targeted Properties

具有目标特性的扩展结构的定向组装

基本信息

批准号：
EP/H035052/1
负责人：
Paul Robert Raithby
金额：
$ 18.48万
依托单位：
University of Bath
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FH035052%2F1
关键词：
Directed Assembly Extended Structures Targeted

项目摘要

There has been an exponential growth in the Chemical Sciences over the last two decades and in the current socio-economic environment it is apparent that the chemical sciences will be central in the drive for cleaner, more efficient energy sources and in solutions to issues of environmental pollution and global warming, while also underpinning advances in healthcare and supporting the drive to combat terrorism. Fundamental to all these issues is a deeper understanding of how processes occur at the molecular level and nanometre level, how this knowledge may be applied to generate materials with particular properties across all the size scales from molecules to bulk materials, and how these materials may find applications in modern society that will be of benefit to all. This is very much the Grand Challenge for the next few decades and incorporates not only chemical scientists, but also biologists, physicists, materials scientists, mathematicians, engineers, economists and educators. Much of the progress is dependant on an understanding of chemistry beyond the molecule and the directed assembly of extended structures with targeted properties . Our control over the assembly of atoms into molecules and materials, and the controlled assembly of molecules into both solid-state and aggregates in solution, remains very limited in scope, setting limits on the ability of chemists and materials scientists to design materials with desired properties even in cases where the underlying material requirements for a particular property are understood. Control of covalent bond formation in conventional synthesis of molecules with strong bonds is good and remarkably complex molecules can be prepared with confidence in multi-step (and increasingly in single-pot) syntheses. In contrast, much more limited control is possible in the preparation of solid-state materials, by techniques such vapour deposition for infinite structures, crystal engineering (employing non-covalent intermolecular interactions and utilising molecules as the basic building blocks) for molecular solids, or solution-phase assembly of molecular components using intermolecular interactions. Covalent bond formation in small molecules can be seen as the first step in an exploration of chemical assembly that needs to be dramatically extended if we are to meet our goal of achieving the a priori design of functional materials. Our contention is that this can be achieved by the incorporation of the use of molecular synthons and non-covalent interactions, to drive the assembly of more complex systems with the same degree of certainty and control that is already achievable for molecular synthesis. By achieving this goal, biological levels of complexity and function could be imposed on artificial materials, with all the evident benefits.We now propose to set up a network to identify the key areas of the Grand Challenge to develop methods to direct the assembly of extended structures with targeted properties and to produce a strategic roadmap to meet the challenge and overcome the barriers. The network will consist of a wide range of scientists, members of the industrial community, members of learned societies, funding bodies and policy makers. A series of general and themed meetings will be held and a roadshow will promote the Grand Challenge to the wider community. The propsal has been submitted by a group of seven researchers, all of whom have contributed extensively to the development of the ideas emanating from an initial Grand Challenges Meeting in late 2008. The team is Professor Paul Raithby (PI, University of Bath), Dr Harris Makatsoris (Brunel University), Professor George Jackson (Imperial College, London), Professor Matthew Rosseinsky (University of Liverpool), Professor Michael Ward (University of Sheffield) and Professor Chick Wilson (University of Glasgow).

在过去的二十年中，化学科学呈指数级增长，在当前的社会经济环境中，很明显，化学科学将在清洁，更有效的能源来源以及解决环境污染和全球变暖问题的解决方案方面至关重要，同时在医疗保健和支持对战斗恐怖袭击方面的发展也是如此。所有这些问题的基础是对过程如何在分子水平和纳米水平上发生的过程进行更深入的了解，如何将这些知识应用于从分子到散装材料的所有尺寸尺度中生成具有特定特性的材料，以及这些材料如何在现代社会中找到对所有材料的应用。这是未来几十年的巨大挑战，不仅融合了化学科学家，还包括生物学家，物理学家，材料科学家，数学家，工程师，经济学家和教育者。许多进步取决于对分子以外的化学的理解以及具有靶向特性的扩展结构的定向组装。我们对原子组装成分子和材料的控制，以及在溶液中将分子组装到固态和聚集体中，在范围中仍然非常有限，对化学家和材料科学家设计具有所需特性的能力，即使在理解了特定特性的基本材料需求的情况下，也是如此。在具有较强键的分子的常规合成中，对共价键形成的控制是良好且非常复杂的分子，可以在多步（越来越多地在单锅中）合成中置信。相比之下，通过制备固态材料，通过用于无限结构的蒸气沉积，晶体工程（采用非共价分子间相互作用，并利用分子作为基本构件）来制备固态材料，可以进行更有限的控制。小分子中的共价形成可以看作是化学组装探索的第一步，如果我们要实现实现功能材料的先验设计的目标，则需要大幅度扩展。我们的论点是，这可以通过纳入分子合成子和非共价相互作用来实现，以驱动具有相同程度的确定性和控制的更复杂系统的组装，这对于分子合成是可以实现的。通过实现这一目标，可以在人造材料上强加生物学的复杂性和功能水平，并具有所有明显的好处。我们现在建议建立一个网络，以确定宏伟挑战的关键领域，以开发方法，以指导具有目标特性的扩展结构组装，并产生战略路线图，以应对挑战并克服障碍物。该网络将由众多的科学家，工业界的成员，学识渊博的社会，资助机构和政策制定者的成员组成。将举行一系列的一系列通用和主题会议，路演将促进对更广泛社区的巨大挑战。 The propsal has been submitted by a group of seven researchers, all of whom have contributed extensively to the development of the ideas emanating from an initial Grand Challenges Meeting in late 2008. The team is Professor Paul Raithby (PI, University of Bath), Dr Harris Makatsoris (Brunel University), Professor George Jackson (Imperial College, London), Professor Matthew Rosseinsky (University of Liverpool), Professor Michael Ward (University of谢菲尔德）和希克·威尔逊（Chick Wilson）教授（格拉斯哥大学）。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Why don't we find more polymorphs?

DOI：
10.1107/s2052519213018861
发表时间：
2013-08-01
期刊：
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS
影响因子：
1.9
作者：
Price, Sarah L.
通讯作者：
Price, Sarah L.

The directed assembly grand challenge network.