BLOOD PRESSURE CONTROL IN JUVENILES - LONGITUDINAL STUDY

描述：（改编自申请人的摘要）本提案是 为了继续对儿童进行纵向研究（一项 年龄在6-16岁之间），激素对血液的影响 正在检查压力。 孩子们每年两次抽血 测量血压和人体测量学，并收集过夜尿样 用于测量醛固酮、肾上腺雄激素（AA）、黄体生成素 (LH)钠、钾和肌酸酐。 增长率和变化 血压随年龄增长的变化已经很好地表征了这一点 人口 从最初的观察来看， 在种族群体之间观察;特别是，黑人儿童被发现 消耗更少的钾，产生约40%的醛固酮， 血压比白色儿童高。 据观察， 高血压家族史阳性者， 醛固酮排泄率。 作为拟议续设 纵向研究，假设将被测试，儿童与 低醛固酮水平易导致高血压。 虽然 横截面数据显示， 醛固酮产生的种族差异只有一部分是 其次是较低的钾摄入量（钾是一种已知的刺激， 醛固酮产生）。 已知醛固酮生成量低的受试者 （黑人和白人）将有补充钾的饮食来测试 假设低醛固酮产生的黑人具有减少的 对钾的反应性，与白色儿童相比 低醛固酮 有耐钾性贫血儿童的家庭 低醛固酮生产将被筛选的证据 低醛固酮产生，并进行分离分析， 建立“低醛固酮”表型的遗传模式。 在 在横断面研究中，AA排泄率与 大于或等于10岁的受试者的血压， 这表明肾上腺在决定血液中的重要作用 年轻人的压力水平。 在未来的纵向研究中， 随着越来越多的儿童达到 青春期（目前的平均年龄为12.7岁）。 此外，本发明还提供了一种方法， 为了更好地区分肾上腺，性腺， 以及体型的增加对血压的影响，一系列的病人， 将这些现象分开来研究。

DESCRIPTION: (Adapted from Applicant's Abstract) The present proposal is for a continuation of a longitudinal study of children (a biracial population, ages 6-16 years) for whom influences of hormones on blood pressure are being examined. Twice yearly the children have had blood pressure and anthropometics measured, and overnight urine samples collected for measurement of aldosterone, adrenal androgens (AA), luteinizing hormone (LH), sodium, potassium, and creatinine. Rates of growth and the changes in blood pressure with age have been well characterized for this population. From the original observations, several differences were observed between racial groups; specifically, black children were found to consume less potassium, produce about 40% less aldosterone and have higher blood pressures than white children. It was observed that children with positive families histories of hypertension were more likely to have lower aldosterone-excretion rates. As part of the proposed continuation of longitudinal studies, the hypothesis would be tested that children with low-aldosterone levels are predisposed to higher blood pressures. Although black children had lower potassium intakes, cross-sectional data indicated that only part of the racial difference in aldosterone production was secondary to a lower intake of potassium (potassium is a known stimulus of aldosterone production). Subjects with known low-aldosterone production (blacks and whites) would have diets supplemented with potassium to test the hypothesis that blacks with low-aldosterone production have a reduced responsiveness to potassium when compared to white children with low-aldosterone. Families of children with potassium-resistant low-aldosterone production would be screened for evidence of low-aldosterone production, and segregation analyses would be performed to establish the mode of inheritance of the "low-aldosterone" phenotype. In cross-sectional studies, AA-excretion rates were positively related to blood pressure in subjects greater than or equal to 10 years of age, suggesting an important role for the adrenarche in determining blood pressure levels in young people. In future longitudinal studies the role of AA as well as gonadal hormones would be studied as more children reach adolescence (the current mean age of the cohort is 12.7 yr). In addition, to better distinguish the individual influences of adrenarche, gonadarche, and increases in body size on blood pressure, a series of patients where these phenomenon are dissociated would be studied.