Effects of Somatic Growth and Sodium Retention on Blood Pressure

高血压是一种病因不明的疾病。大多数研究者认为， 钠（Na）是血压（BP）持续升高的基础，而BP是高血压的特征。 在儿童中，血压升高伴随着身高和体重的身体增长。虽然BP被认为是 与各种躯体测量相关，所观察到的生理机制 关联尚不清楚。此外，很少有调查研究是否有任何 躯体生长的特征与血压升高或高血压前期的早期发作有关， 高血压我们的初步数据有力地表明，体细胞生长的过程是良好的， 与BP的发展同步。有了令人信服的数据证据，我们建议 进行流行病学研究，以描述躯体生长、钠潴留和 BP使用现有儿童队列的数据。我们假设， 青春期生长期间伴随BP的体细胞生长至少部分是通过增加 保留Na。沿着这条线，我们将检查躯体变化对钠测量的影响。 保留，以及身体生长特征对青春期后血压和青春期前血压的影响。 高血压和高血压。这项研究解决了一些至关重要的，但以前 关于青春期血压变化机制的未解之谜。的假设是 来自强有力和令人信服的初步数据证据。如果成功实施， 研究可能会发现高血压的早期危险因素， 干预措施。为了评估青春期后血压和高血压前期和高血压的发病情况，我们 寻求将队列中350例受试者的随访期再延长5年，直至 受试者变成成人。现有的队列和新的扩展将提供难得的机会， 评估青春期躯体生长模式与青春期后BP之间的联系， 钠潴留的调节。为了执行，我们提出了一项综合分析计划。通过 在血压达到高血压水平之前， 为研究机理提供了新的途径。虽然这项研究具有科学意义， 由于它充分利用了现有的纵向数据，因此也具有成本效益。

Hypertension is a disease of unknown etiology. Most investigators agree that retention of excess sodium (Na) underlies the sustained increase in blood pressure (BP) that characterizes hypertension. In children, BP elevation accompanies somatic growth in height and weight. While BP is known to be correlated to various somatic measurements, physiological mechanisms that underlie the observed associations remain unclear. Additionally, few investigations have examined whether any characteristics of somatic growth relate to the rise of BP or to the early onset of pre-hypertension or hypertension. Our preliminary data strongly suggest that the process of somatic growth is well synchronized with that of BP development. With the compelling data evidence, we propose to conduct an epidemiological study to delineate the relations among somatic growth, Na retention, and BP using data from an existing cohort of children. We hypothesize that a strong relationship of somatic growth with BP during the period of pubertal growth is mediated at least partially by increases in retention of Na. Along this line, we will examine the effects of somatic changes on measures of Na retention, and the effects of somatic growth characteristics on post-pubertal BP and the onset of pre- hypertension and hypertension. The study addresses some of the critically important but previously unanswered questions about the mechanisms of BP change during puberty. The hypotheses are derived from strong and compelling preliminary data evidence. If successfully carried out, the research may uncover early risk factors for hypertension, affording opportunities of timely interventions. To assess the post-pubertal BP and onset of pre-hypertension and hypertension, we seek to extend the follow-up period for 350 subjects in the cohort for five additional years till the subjects become adults. The existing cohort and the new extension will afford a rare opportunity to assess the linkage between somatic growth patterns in puberty and post-pubertal BP, with accommodation of Na retention. To implement, we have proposed an integrated analytical plan. By focusing on the beginnings of hypertension, before BP reaches hypertensive levels, this research provides a new approach for investigating mechanisms. While scientifically significant, the study is also cost effective because it fully utilizes the existing longitudinal data.