CNS EFFECTS OF ANTIHYPERTENSIVE THERAPIES

抗高血压治疗对中枢神经系统的影响

• 批准号: 3566807
• 负责人: JOHN B KOSTIS
• 金额: $ 26.23万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3566807
• 关键词: ACE inhibitors; antihypertensive agents; atenolol; behavioral medicine; beta antiadrenergic agent; cardiovascular disorder chemotherapy; cardiovascular function; case history; central nervous system; clonidine; cognition; drug adverse effect; enalapril; female; human middle age (35-64); human subject; human therapy evaluation; male; metabolism; placebos; postmenopause; propranolol; psychomotor function; respiratory center dysfunction; sleep

The proposed research will broaden and intensify our current investigation of physiological and neuropsychological sequellae of antihypertensive therapies. Using the laboratory-based, quantitative assessment methodology developed in our initial study with normotensive males, two additional studies are proposed to evaluate nonpharmacological and pharmacological treatment effects in male and female hypertensives. Of particular interest are the effects of well tolerated antihypertensive agents, such as ACE inhibitors and hydrophilic beta blockers on measures of sleep physiology, cognitive and perceptual-motor function, and mood state. These effects are to be related, where possible, to changes in cardiovascular, circulatory, and metabolic function. We are als proposing to conduct the first studies of this type in post-menopausal female patients. Finally, both the studies proposed will include intensive comparisons of pharmacological therapy with the highly successful nonpharmacological treatment program developed in our current research. Study I will consist of a randomized, placebo-controlled evaluation of treatment effects in 64 male hypertensive patients assigned to one of several pharmacological conditions (enalapril, atenolol, placebo) or nonpharmacological treatment. Selected CNS parameters, including sleep, cardiovascular, and metabolic functions will be assessed before and after each treatment phase. Study II is the first prospective, placebo- controlled evaluation of biobehavioral sequellae of treatment in female patients. Specifically, 64 post-menopausal female hypertensives will be randomly assigned to propranolol, enalapril, placebo or nonpharmacological therapy. Current assessment procedures will be modified accordingly for this study. Taken together, these studies will provide an in-depth evaluation of biobehavioral sequellae of current antihypertensive therapies, and will be of value in the clinical management of cardiovascular disease.

拟议的研究将扩大和加强我们目前的调查

项目成果

Beta blocker effects on heart rate during sleep: a placebo-controlled polysomnographic study with normotensive males.

β受体阻滞剂对睡眠期间心率的影响：一项针对血压正常男性的安慰剂对照多导睡眠图研究。

• DOI: 10.1093/sleep/14.1.43
• 发表时间: 1991
• 期刊: Sleep
• 影响因子: 5.6
• 作者: Rosen,RC;Kostis,JB;Seltzer,LG;Taska,LS;Holzer,BC
• 通讯作者: Holzer,BC

Nondrug treatment approaches for hypertension.

高血压的非药物治疗方法。

• 发表时间: 1989
• 期刊: Clinics in geriatric medicine
• 影响因子: 3.3
• 作者: Rosen,RC;Kostis,JB;Brondolo,E
• 通讯作者: Brondolo,E

Superiority of nonpharmacologic therapy compared to propranolol and placebo in men with mild hypertension: a randomized, prospective trial.

对于轻度高血压男性，非药物治疗相对于普萘洛尔和安慰剂的优越性：一项随机、前瞻性试验。

• DOI: 10.1016/0002-8703(92)90662-f
• 发表时间: 1992
• 期刊: American heart journal
• 影响因子: 4.8
• 作者: Kostis,JB;Rosen,RC;Brondolo,E;Taska,L;Smith,DE;Wilson,AC
• 通讯作者: Wilson,AC