Engineering floating liquid marbles for three-dimensional cell cultures

为三维细胞培养设计浮动液体弹珠

• 批准号: DP170100277
• 负责人: Prof Nam-Trung Nguyen
• 金额: $ 29.59万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-06-21 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100277
• 关键词: Engineering; floating; liquid; marbles; three

This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.

这个项目的目的是了解三维细胞培养的物理在一个液体大理石浮动在液体自由表面。开发的新方法可以在不使用基质或支架的情况下生产这些细胞培养物，并且运行时间远远超过现有技术。这种方法紧密模拟正常的体内环境，并产生细胞移植治疗所需的球状体。该项目将解决基本现象中的不确定性。预期的结果应该支持未来适合移植治疗的高质量细胞培养。