Engineering floating liquid marbles for three-dimensional cell cultures

为三维细胞培养设计浮动液体弹珠

• 批准号: DP170100277
• 负责人: Prof Nam-Trung Nguyen
• 金额: $ 29.59万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-06-21 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100277
• 关键词: Engineering; floating; liquid; marbles; three

This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.

该项目旨在了解漂浮在无液体表面上的液体大理石中的三维细胞培养物的物理。开发的新方法可以生产这些细胞培养物，而无需使用矩阵或脚手架，并且跑步时间远远超出了现有技术。该方法密切模仿正常的体内环境，并在细胞移植疗法中产生所需的球体。该项目将解决基本现象中的不确定性。预期的结果应支持未来适合移植疗法的高质量细胞培养物。