CO2 AND AEROSOL TRANSPORT ALONG LUNG AIRWAYS

建议继续研究二氧化碳气体和吸湿性。 气溶胶粒子在呼吸道内的运动。三个具体的 临床上重要的假说正在被检验：1)喷射导管 新生儿高频喷射通气(HFJV)的设计与定位 对气体交换效率和气管壁有重大影响 损伤和剪切率，2)气道量和位置 可以控制和最大化吸湿性雾化药物沉积 通过相对简单和廉价的程序，以及3)如此重要 可获得有关腺泡呼吸道结构的新诊断信息 计算机稳态分析对活体的非侵入性 嘴里记录的二氧化碳洗出曲线。这三个假设是 联系在一起的是他们都依赖于获得更深层次的 对气体和气溶胶沿河流的运动或输送的理解 由宏观对流和宏观对流两种物理机制所致 微观分子扩散。用来测试这些的方法 假说涉及物理计算机和数值计算机的结合使用 健康人和疾病人肺的模型及测量 (COPD)人类受试者。这种结合的方法非常成功。 到目前为止，在阐明呼吸道运输过程的许多特征和 是在理论和实践上取得进展的最佳方法 理解和实际应用。

Research is proposed to continue the study of CO2 gas and hygroscopic aerosol particle motion within the respiratory airways. Three specific clinically important hypotheses are being tested: 1) that jet catheter design and location in high frequency jet ventilation (HFJV) in neonates have a major influence on gas exchange efficiency and tracheal wall damage and shear rate, 2) that the amount and location of airway hygroscopic aerosolized drug deposition can be controlled and maximized by relatively simple and inexpensive procedures, and 3) that important new diagnostic information on acinar airway structure can be obtained noninvasively on a living person from computer analysis of steady state CO2 washout curves recorded at the mouth. These three hypotheses are linked together by the fact that they all depend on obtaining a deeper understanding of the motion or transport of gases and aerosols along the airways by the two physical mechanisms of macroscopic convection and microscopic molecular diffusion. The methods used to test these hypotheses involve the combined use of physical and numerical computer models along with measurements on the lungs of healthy and diseased (COPD) human subjects. This combined approach has been very successful so far in elucidating many features of the airway transport process and is the optimal method of achieving progress in both theoretical understanding and practical application.