CO2 AND AEROSOL TRANSPORT ALONG LUNG AIRWAYS

二氧化碳和气溶胶沿肺部气道的传输

• 批准号: 3346228
• 负责人: PETER W SCHERER
• 金额: $ 14.07万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3346228
• 关键词: aerosols; biomedical equipment safety; carbon dioxide transport; catheterization; cinematography; computer data analysis; high frequency ventilation; human subject; image processing; mathematical model; mechanical stress; model design /development; newborn human (0-6 weeks); pharmacokinetics; physical model; respiratory airflow disorder; respiratory airway pressure; respiratory gas level; respiratory gas transport; respiratory system; trachea

Research is proposed to continue the study of CO2 gas and hygroscopic aerosol particle motion within the respiratory airways. Three specific clinically important hypotheses are being tested: 1) that jet catheter design and location in high frequency jet ventilation (HFJV) in neonates have a major influence on gas exchange efficiency and tracheal wall damage and shear rate, 2) that the amount and location of airway hygroscopic aerosolized drug deposition can be controlled and maximized by relatively simple and inexpensive procedures, and 3) that important new diagnostic information on acinar airway structure can be obtained noninvasively on a living person from computer analysis of steady state CO2 washout curves recorded at the mouth. These three hypotheses are linked together by the fact that they all depend on obtaining a deeper understanding of the motion or transport of gases and aerosols along the airways by the two physical mechanisms of macroscopic convection and microscopic molecular diffusion. The methods used to test these hypotheses involve the combined use of physical and numerical computer models along with measurements on the lungs of healthy and diseased (COPD) human subjects. This combined approach has been very successful so far in elucidating many features of the airway transport process and is the optimal method of achieving progress in both theoretical understanding and practical application.

拟继续研究CO2气体和吸湿性 气溶胶颗粒在呼吸道内运动。 三具体 临床上重要的假设正在接受测试：1）喷射导管 新生儿高频喷射通气 (HFJV) 的设计和定位 对气体交换效率和气管壁有重要影响 损伤和剪切速率，2）表示气道的数量和位置 可以控制并最大化吸湿性雾化药物沉积 通过相对简单且廉价的程序，以及 3) 重要的是 可以获得有关腺泡气道结构的新诊断信息 通过计算机对稳态的分析对活人进行无创治疗 在口腔记录 CO2 冲刷曲线。 这三个假设是 由于它们都依赖于获得更深入的了解，因此将它们联系在一起 了解气体和气溶胶沿线的运动或传输 气道通过宏观对流和 微观分子扩散。 用于测试这些的方法 假设涉及物理和数字计算机的结合使用 模型以及对健康和患病肺部的测量 （慢性阻塞性肺病）人类受试者。 这种组合方法非常成功 到目前为止，我们已经阐明了航空运输过程的许多特征， 是在理论和实践方面取得进展的最佳方法 理解和实际应用。