CO2 AND AEROSOL TRANSPORT ALONG LUNG AIRWAYS

二氧化碳和气溶胶沿肺部气道的传输

• 批准号: 2217403
• 负责人: PETER W SCHERER
• 金额: $ 14.61万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2217403
• 关键词: aerosols; biomedical equipment safety; carbon dioxide transport; catheterization; cinematography; computer data analysis; high frequency ventilation; human subject; image processing; mathematical model; mechanical stress; model design /development; newborn human (0-6 weeks); pharmacokinetics; physical model; respiratory airflow disorder; respiratory airway pressure; respiratory gas level; respiratory gas transport; respiratory system; trachea

Research is proposed to continue the study of CO2 gas and hygroscopic aerosol particle motion within the respiratory airways. Three specific clinically important hypotheses are being tested: 1) that jet catheter design and location in high frequency jet ventilation (HFJV) in neonates have a major influence on gas exchange efficiency and tracheal wall damage and shear rate, 2) that the amount and location of airway hygroscopic aerosolized drug deposition can be controlled and maximized by relatively simple and inexpensive procedures, and 3) that important new diagnostic information on acinar airway structure can be obtained noninvasively on a living person from computer analysis of steady state CO2 washout curves recorded at the mouth. These three hypotheses are linked together by the fact that they all depend on obtaining a deeper understanding of the motion or transport of gases and aerosols along the airways by the two physical mechanisms of macroscopic convection and microscopic molecular diffusion. The methods used to test these hypotheses involve the combined use of physical and numerical computer models along with measurements on the lungs of healthy and diseased (COPD) human subjects. This combined approach has been very successful so far in elucidating many features of the airway transport process and is the optimal method of achieving progress in both theoretical understanding and practical application.

建议继续对CO2气体和吸湿性进行研究

项目成果

Diffusivity, respiratory rate and tidal volume influence inert gas expirograms.

扩散率、呼吸频率和潮气量影响惰性气体呼气图。

• DOI: 10.1016/0034-5687(91)90017-d
• 发表时间: 1991
• 期刊: Respiration physiology
• 作者: Neufeld,GR;Gobran,S;Baumgardner,JE;Aukburg,SJ;Schreiner,M;Scherer,PW
• 通讯作者: Scherer,PW

Numerical and experimental study of steady-state CO2 and inert gas washout.

稳态 CO2 和惰性气体冲洗的数值和实验研究。

• DOI: 10.1152/jappl.1988.64.3.1022
• 发表时间: 1988
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Scherer,PW;Gobran,S;Aukburg,SJ;Baumgardner,JE;Bartkowski,R;Neufeld,GR
• 通讯作者: Neufeld,GR

A model of cigarette smoke particle deposition.

香烟烟雾颗粒沉积模型。

• DOI: 10.1080/15298669091369600
• 发表时间: 1990
• 期刊: American Industrial Hygiene Association journal
• 作者: Muller,WJ;Hess,GD;Scherer,PW
• 通讯作者: Scherer,PW

Modelling steady state pulmonary elimination of He, SF6 and CO2: effect of morphometry.

He、SF6 和 CO2 的稳态肺部消除建模：形态测量的影响。

• DOI: 10.1016/0034-5687(92)90001-d
• 发表时间: 1992
• 期刊: Respiration physiology
• 作者: Neufeld,GR;Schwardt,JD;Gobran,SR;Baumgardner,JE;Schreiner,MS;Aukburg,SJ;Scherer,PW
• 通讯作者: Scherer,PW

The importance of a source term in modeling multibreath inert gas washout.

源项在多次呼吸惰性气体冲刷建模中的重要性。

• DOI: 10.1016/0034-5687(95)00080-1
• 发表时间: 1996
• 期刊: Respiration physiology
• 作者: Scherer,PW;Neff,JD;Baumgardner,JE;Neufeld,GR
• 通讯作者: Neufeld,GR