CO2 AND AEROSOL TRANSPORT ALONG LUNG AIRWAYS

建议继续研究CO2气体和吸湿性 气溶胶粒子在呼吸道内的运动。 三个具体 临床上重要的假设正在测试：1）喷射导管 新生儿高频喷射通气（HFJV）的设计和定位 对气体交换效率和气管壁有重要影响 2）气道的数量和位置 吸湿性雾化药物沉积可以被控制和最大化 通过相对简单和廉价的程序，3）重要的是， 可以获得关于腺泡气道结构的新诊断信息 非侵入性地在活人身上从计算机分析稳态 在口部记录CO2洗脱曲线。 这三个假设是 联系在一起的事实，他们都依赖于获得更深的 了解气体和气溶胶的运动或运输沿着 通过宏观对流和 微观分子扩散 用于测试这些的方法 假设涉及物理和数值计算机的结合使用 模型沿着与健康和患病的肺测量 （COPD）人类受试者。 这种综合方法非常成功 到目前为止，在阐明气道运输过程的许多特征方面， 是在理论和实践上取得进展的最佳方法。 理解和实际应用。

Research is proposed to continue the study of CO2 gas and hygroscopic aerosol particle motion within the respiratory airways. Three specific clinically important hypotheses are being tested: 1) that jet catheter design and location in high frequency jet ventilation (HFJV) in neonates have a major influence on gas exchange efficiency and tracheal wall damage and shear rate, 2) that the amount and location of airway hygroscopic aerosolized drug deposition can be controlled and maximized by relatively simple and inexpensive procedures, and 3) that important new diagnostic information on acinar airway structure can be obtained noninvasively on a living person from computer analysis of steady state CO2 washout curves recorded at the mouth. These three hypotheses are linked together by the fact that they all depend on obtaining a deeper understanding of the motion or transport of gases and aerosols along the airways by the two physical mechanisms of macroscopic convection and microscopic molecular diffusion. The methods used to test these hypotheses involve the combined use of physical and numerical computer models along with measurements on the lungs of healthy and diseased (COPD) human subjects. This combined approach has been very successful so far in elucidating many features of the airway transport process and is the optimal method of achieving progress in both theoretical understanding and practical application.