LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
批准号:
3344103
负责人:
Jerold Alan Last
金额:
$9.6万
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-04-01 至 1988-03-31
中文摘要
胶原交联将在肌腱、骨、皮肤、
软骨和大鼠肺。 使用新开发的HPLC技术,
分离和定量还原和非还原交联,我们
旨在研究不同交联在体内周转。
前体-产品关系将在不同的组织中定义
含有不同类型的胶原蛋白。 我们将专门测试
假设某些关键的交联是最终的
胶原蛋白的代谢命运-降解或沉积为纤维。 成熟
将双官能交联转化为三官能和四官能产物,
仔细检查,以确定不可还原的交联作用,
成熟过程 这些研究应该让我们开始了解
肺细胞外基质中胶原沉积的方面,
正常动物,并应作为必要的数据库,
对这些过程中的畸变进行系统研究,
病理生理学和疾病。
英文摘要
Collagen crosslinking will be characterized in tendon, bone, skin,
cartilage and lungs of rats. Using newly developed HPLC techniques for
separation and quantitation of reduced and of nonreducible crosslinks, we
intend to study turnover of different crosslinks in vivo.
Precursor-product relationships will be defined in different tissues
containing different collagen types. We will specifically test the
hypothesis that certain key crosslinks are markers of the ultimate
metabolic fate of collagen-degradation or deposition as fibers. Maturation
of difunctional crosslinks to tri- and tetrafunctional products will be
closely examined to ascertain the role of nonreducible crosslinks in the
maturation process. These studies should allow us to begin to understand
aspects of collagen deposition in the extracellular matrix of the lung in
normal animals, and should serve as the requisite data base to allow
systematic study of aberrations in these processes secondary to
pathophysiology and disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
International Training Program in Environmental Immunoa*
-
批准号:6540855
-
项目类别:
-
资助金额:$15.0万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Immunoa*
-
批准号:6639994
-
项目类别:
-
资助金额:$15.1万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Immunoa*
-
批准号:6721358
-
项目类别:
-
资助金额:$15.0万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Toxicology and Public Health
-
批准号:8034317
-
项目类别:
-
资助金额:$16.83万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Immunoa*
-
批准号:7243962
-
项目类别:
-
资助金额:$12.3万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Toxicology and Public Health
-
批准号:7780425
-
项目类别:
-
资助金额:$16.83万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Immunoa*
-
批准号:6436267
-
项目类别:
-
资助金额:$15.0万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Immunoa*
-
批准号:6875228
-
项目类别:
-
资助金额:$15.0万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
International Training Program in Environmental Toxicology and Public Health
-
批准号:7572908
-
项目类别:
-
资助金额:$16.83万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
IMMUNOCHEMICAL ANALYSIS OF TOXIC SUBSTANCES IN THE ENVIRONMENT AND IN HUMANS
-
批准号:7251220
-
项目类别:
-
资助金额:$16.83万
-
财政年份:2001
-
负责人:Jerold Alan Last
-
依托单位:
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
-
批准号:3344110
-
项目类别:
-
资助金额:$14.41万
-
财政年份:1985
-
负责人:Jerold Alan Last
-
依托单位:
LUNG COLLAGEN CROSSLINKING - BIOSYNTHESIS & MATURATION
-
批准号:3344104
-
项目类别:
-
资助金额:$12.12万
-
财政年份:1985
-
负责人:Jerold Alan Last
-
依托单位:
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
-
批准号:3344112
-
项目类别:
-
资助金额:$15.39万
-
财政年份:1985
-
负责人:Jerold Alan Last
-
依托单位:
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
-
批准号:3344107
-
项目类别:
-
资助金额:$8.79万
-
财政年份:1985
-
负责人:Jerold Alan Last
-
依托单位:
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
-
批准号:3344108
-
项目类别:
-
资助金额:$9.19万
-
财政年份:1985
-
负责人:Jerold Alan Last
-
依托单位:
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
-
批准号:3344111
-
项目类别:
-
资助金额:$14.99万
-
财政年份:1985
-
负责人:Jerold Alan Last
-
依托单位:
LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
-
批准号:3344109
-
项目类别:
-
资助金额:$12.17万
-
财政年份:1985
-
负责人:Jerold Alan Last
-
依托单位:
海外基金