TECHNIQUES FOR CHARACTERIZATION OF ATHEROSCLEROTIC PLAQU

动脉粥样硬化斑块的特征将通过 基于反射分析的方法的发展和使用 用垂直于动脉的声束采集的超声信号。 这些技术将在检测非阻塞流方面发挥作用。 引起症状的斑块，以及进展/消退研究中的斑块 人类的斑块。 要使用的信号措施是，来自 径向血流、血管大小、斑块回声幅度、斑块 衰减，以及基于倒谱分析的血管壁结构。在……里面 此外，墙阻抗和损耗分布将通过使用 正在开发中的精确反演方法。 数据将从模体中获得，用于设备校准和作为 检查方法的准确性。来自旧身体的血管，含有 可见的斑块将被用来将超声波和病理联系起来 调查结果。选定的患者将在托马斯·杰斐逊医院接受检查 大学医院血管实验室，以及与x射线和 手术标本遵循为B型建立和使用的方案 评估联系工作。数据将被数字化并存储在磁盘上 在Drexel的初始离线分析，该系统稍后将修改为 在临床上进行分析。

The characterization of atherosclerotic plaque will be investigated through the development and use of methods based on analysis of reflected ultrasonic signals taken with the sound beam perpendicular to the artery. These techniques will be useful in examination of non flow-obstructing plaque that causes symptoms, and in studies in progression/regression of plaque in humans. Signal measures to be used are, Doppler-shifted signals from radially-directed flow, vessel dimensions, plaque echo amplitude, plaque attenuation, and vessel wall structure based on cepstrum analysis. In addition, wall impedance and loss profiles will be obtained through use of exact inversion methods under development. Data will be obtained from phantoms for equipment calibration and as a check on accuracy of methods. Vessels from older cadavers containing visible plaque will be used to correlate ultrasound and pathology findings. Selected patients will be examined at Thomas Jefferson University Hospital Vascular Lab, and data correlated with x-ray and surgery specimens following protocols established and used for the B-mode assessment contact effort. Data will be digitized and stored on disk for initial off-line analysis at Drexel, on a system to be modified later to perform analysis in the clinic.