DEVELOPING OF ULTRASONIC TISSUE CHARACTERIZATION METHODS

该计划项目旨在提高超声成像的能力 以检测和确定肿瘤的特征。之所以选择这个地区，是因为 超声成像在几乎所有医疗领域的广泛使用 专家。我们寻求的改进，选择制造超声波 成像甚至更有用，因此会对医学产生很大影响 练习一下。他们将通过改进检测为肿瘤学做出贡献， 诊断和治疗监测。 该方案主要由采取不同方法的项目组成 涉及处理原始回波数据以形成图像的问题。 这些项目基于新的方法以及对 在工业无损检测领域取得成功的方法 测试和光学方面。我们的项目提供实验室和临床 联合数据收集的核心，并确保互动和 项目之间和成像方式之间的协调(US、CT 和MRI)和病理学。此结构应该会删除许多 在尝试改进超声波时遇到的问题 通过单独的研究项目进行组织表征。另外， 临床合作者将受益于拥有各种可用的 成像方法要针对不同的目的进行评价。国际间- 因此，可以有效地处理与其他模式的比较。 其中一个项目将把来自小血管的多普勒血流数据整合到 数据集。要确保此程序保持与超声波一样的最新状态 方法的进步在赠款的期限内，我们包括了工作 在相关领域。某些类型的造影剂很可能会被广泛使用 在不久的将来使用。因此，我们包括了一个项目，该项目是 开发两种很有前途的新造影剂。该项目还将 允许我们在表征这些材料方面获得经验，并提供 关于使用对比度来增强相关图像特征的指南 得了肿瘤。 传感器和测量系统项目已经完成，以便 我们能够进行超声波剂量测量。这个项目现在将 开发用于宽带数据收集的传感器，这是 正在开发新方法的项目，并将为 临床应用。 计划进行一项主要工作，通过以下方式评估成像方面的改进 直接与现有图像进行比较。其中包括特征提取 方法来评估现有数据，并在Receive中进行新的工作 使用新功能进行额外测试的工作特性(ROC)分析 数据集。

The Program Project seeks to enhance the ability of ultrasonic imaging to detect and characterize tumors. This area was chosen because of the widespread use of ultrasonic imaging in practically all medical specialists. The improvements that we seek, selected to make ultrasonic imaging even more useful, would thus have a large impact upon medical practice. They would contribute to oncology through improved detection, diagnosis and treatment monitoring. The program consists primarily of projects that take different approaches to the problem of processing the original echo data to form images. These projects are based on new approaches as well as on adaptations of approaches that have been successful in industrial non-destructive testing and in optics. Our program provides laboratory and clinical cores for joint data collection, and assuring interaction and coordination between the projects and between imaging modalities (US, CT and MRI) and pathology. This structure should remove many of the problems that have been encountered when attempting to improve ultrasonic tissue characterization through individual research projects. Also, the clinical collaborators will benefit from having available a variety of image formation methods to evaluate for different purposes. The inter- comparison with other modalities can thus be efficiently handled. One project will integrate doppler flow data from small vessels into the data set. To assure that this program remains current as ultrasonic methodology advances during the term of the grant we have included work in related areas. Some type of contrast agent will most likely be widely used in the near future. Therefore, we have included a project that is developing two promising new contrast agents. This project also will allow us to gain experience with characterizing these materials and offer guidance on the use of contrast in enhancing image features associated with tumors. A transducer and measurement system project has been completed so that we are able to perform ultrasonic dosimetry. This project will now develop transducers for wideband data collection that is needed for the projects that are developing new methods, and will be convenient for clinical use. A major effort is planned in assessing the improvements in imaging by direct comparison to existing images. These include feature extraction methods to evaluate the existing data, and a new effort in Receive Operating Characteristic (ROC) analysis for additional testing using new data sets.