MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS

气管、支气管、肺血管的肌肉超微结构

• 批准号: 3350018
• 负责人: GIORGIO GABELLA
• 金额: $ 4.69万
• 依托单位: UNIVERSITY OF LONDON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1988-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3350018
• 关键词: animal age group; bronchus; electron microscopy; histology; hypercapnia; hypoxia; neuromuscular junction; pulmonary circulation; respiratory muscles; smooth muscle; trachea; vascular smooth muscle

A study by light and electron microscopy of the fine structure and innervation of the musculature of trachea, bronchi and pulmonary blood vessels in mammals. Systematic and comparative study based on quantitative and morphometric methods. Study of a large set of structural parameters, ranging from the three-dimensional arrangement of muscle cells, cell layers and cell bundles, to the packing density and size of muscle cells, the amount of extracellular material and the occurrence and distribution of non-muscle cells (such as nerves, endothelial cells, interstitial cells, fibroblasts), and to the cytological features of the muscle cells, including cell-to-cell, cell-to-stroma and nerve-muscle junctions. Comparison between various segments of the airways in normal adult mice, rats, guinea-pigs and rabbits. Comparison of the musculature of airways and pulmonary vessels in rats and rabbits from birth to senescence. Comparison of the musculature and its innervation in laboratory rats (and rabbits), in wild rats (and rabbits) and in germ-free rats. Characterization of the structural changes in the musculature in rats exposed to chronic hypoxia and/or hypercapnia. The aim of these comparisons is to define the specific features of each individual muscle and to help to understand the functional significance of the variety of structural features, as a necessary step to form a basis for the study of muscle pathology.

通过光学和电子显微镜研究其精细结构和 气管、支气管和肺血肌肉组织的神经支配 哺乳动物体内的血管。 基于定量和形态测量的系统比较研究 方法。 研究大量结构参数，范围从 肌肉细胞、细胞层和细胞的三维排列 束，根据肌肉细胞的堆积密度和大小， 细胞外物质和非肌肉物质的发生和分布 细胞（如神经、内皮细胞、间质细胞、成纤维细胞）， 以及肌肉细胞的细胞学特征，包括 细胞与细胞、细胞与基质以及神经-肌肉连接。 比较 正常成年小鼠、大鼠气道各段之间 豚鼠和兔子。 大鼠和大鼠气道和肺血管肌肉组织的比较 兔子从出生到衰老。 实验室大鼠（和 兔子）、野生大鼠（和兔子）和无菌大鼠。 大鼠肌肉组织结构变化的表征 暴露于慢性缺氧和/或高碳酸血症。 这些比较的目的是定义每个的具体特征 个体肌肉并帮助理解其功能意义 各种结构特征，作为形成基础的必要步骤 肌肉病理学的研究。