MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS
MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS
批准号:
3350017
负责人:
GIORGIO GABELLA
金额:
$4.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-09-30 至 1988-09-29
中文摘要
用光学显微镜和电子显微镜研究了其精细结构和
气管、支气管肌和肺血的神经支配
哺乳动物体内的血管。
基于定量和形态计量学的系统比较研究
方法:研究方法。
研究了一大组结构参数,从
肌细胞、细胞层和细胞的三维排列
束,与肌肉细胞的堆积密度和大小有关,
细胞外物质与非肌肉组织的发生与分布
细胞(如神经、内皮细胞、间质细胞、成纤维细胞),
以及肌肉细胞的细胞学特征,包括
细胞到细胞、细胞到间质和神经肌肉连接。比较
在正常成年小鼠、大鼠、
几内亚--猪和兔子。
大鼠呼吸道和肺血管肌层结构的比较
兔子从出生到衰老。
实验大鼠肌肉系统及其神经支配的比较
在野鼠(和兔子)和无菌大鼠中。
大鼠肌肉系统结构变化的特征
暴露于慢性缺氧和/或高碳酸血症。
这些比较的目的是定义每个
并有助于理解单个肌肉的功能意义
结构特征的多样性,作为形成基础的必要步骤
肌肉病理学的研究。
英文摘要
A study by light and electron microscopy of the fine structure and
innervation of the musculature of trachea, bronchi and pulmonary blood
vessels in mammals.
Systematic and comparative study based on quantitative and morphometric
methods.
Study of a large set of structural parameters, ranging from the
three-dimensional arrangement of muscle cells, cell layers and cell
bundles, to the packing density and size of muscle cells, the amount of
extracellular material and the occurrence and distribution of non-muscle
cells (such as nerves, endothelial cells, interstitial cells, fibroblasts),
and to the cytological features of the muscle cells, including
cell-to-cell, cell-to-stroma and nerve-muscle junctions. Comparison
between various segments of the airways in normal adult mice, rats,
guinea-pigs and rabbits.
Comparison of the musculature of airways and pulmonary vessels in rats and
rabbits from birth to senescence.
Comparison of the musculature and its innervation in laboratory rats (and
rabbits), in wild rats (and rabbits) and in germ-free rats.
Characterization of the structural changes in the musculature in rats
exposed to chronic hypoxia and/or hypercapnia.
The aim of these comparisons is to define the specific features of each
individual muscle and to help to understand the functional significance of
the variety of structural features, as a necessary step to form a basis for
the study of muscle pathology.
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MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS
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批准号:3350016
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项目类别:
-
资助金额:$0.42万
-
财政年份:1987
-
负责人:GIORGIO GABELLA
-
依托单位:
MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS
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批准号:3350018
-
项目类别:
-
资助金额:$4.69万
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财政年份:1985
-
负责人:GIORGIO GABELLA
-
依托单位:
MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS
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批准号:3350013
-
项目类别:
-
资助金额:$3.67万
-
财政年份:1985
-
负责人:GIORGIO GABELLA
-
依托单位:
海外基金