ATRIAL FLUTTER IN A MODEL

这项研究计划的长期目标是应用 现代电生理学和药理学技术 对房颤的发生机制有更深入的了解 为房颤的治疗发展更好的基础 颤动。研究计划的具体目标包括使用 心包炎犬心房扑动模型及复律技术 从放置在心房1)上的240个电极同时记录 描述心房扑动时折返回路的性质；2) 心房扑动中心传导性质的研究 再入电路；3)表征完全瞬时卷吸和 4)术中使用快速心房起搏。 窦性心律与心房扑动(夹带)时的特征 构成心房扑动折返回路的组织传导 在右心房；5)表征心脏支点的传导。 激活波前；6)研究抗心律失常等如何选择 药物作用于心房扑动折返回路；7)测试疗效 为预防房颤诱发性而选择的干预措施 颤动。这些研究将涉及15个假设，这些假设与 房扑的维持，房扑的治疗，以及 预防心房扑动。将使用的方法进一步 在这种犬模型中对心房扑动的特征和研究包括 使用无菌手术建立无菌心包炎犬模型， 使用标准外科技术再次暴露心脏 慢性无菌心包炎后；多用途的使用 在各种电生理学研究中的记录技术； 心脏起搏技术的使用；标准药理学的使用 选定代理的管理技术。健康 这个项目的关联性很明显，因为心房扑动是一口井 已知的，临床上令人困扰的和鲜为人知的异常 影响了大量的患者。建议的研究应 提供重要的新信息，以帮助加深了解和 治疗患有这种异常的病人。

The long term objectives of this research plan are to apply contemporary electrophysiological and pharmacological techniques to obtain an improved understanding of the mechanisms responsible for atrial flutter and to develop an improved basis for the treatment of atrial flutter. The specific aims of the research plan include the use of the pericarditis canine model of atrial flutter and multiplexing techniques to record simultaneously from 240 electrodes placed on the atrial 1) to characterize the nature of the reentry circuit during atrial flutter; 2) to study the nature of conduction in the center of the atrial flutter reentry circuit; 3) to characterize fully transient entrainment and interruption of atrial flutter; 4) to utilize rapid atrial pacing during sinus rhythm and during atrial flutter (entrainment) to characterize conduction in tissues that constitute the atrial flutter reentry circuit in the right atrium; 5) to characterize conduction at pivot points of activation wave fronts; 6) to study how antiarrhythmic and other selected agents act on the atrial flutter reentry circuit; 7) to test the efficacy of selected interventions for the prevention of inducibility of atrial flutter. The studies will address 15 hypotheses concerned with the maintenance of atrial flutter, the treatment of atrial flutter, and the prevention of atrial flutter. The methods to be used to further characterize and study atrial flutter in this canine model include the use of aseptic surgery to create the sterile pericarditis canine model, the use of standard surgical techniques to expose the heart again following creation of chronic sterile pericarditis; the use of multiplex recording techniques during the various electrophysiologic studies; the use of cardiac pacing techniques; and the use of standard pharmacological techniques for the administration of selected agents. The health relatedness of the project is clear, in that atrial flutter is a well known, clinically troublesome, and poorly understood abnormality affecting patients in significant numbers. The proposed studies should provide important new information to assist in improved understanding and treatment of patients suffering from this abnormality.