Differences in Women and Men with Atrial Fibrillation

女性和男性房颤患者的差异

• 批准号: 10822952
• 负责人: Elizabeth Frazier
• 金额: $ 5.02万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-16 至 2026-03-15
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10822952
• 关键词: Ablation; Address; Adipose tissue; Age; Anti-Inflammatory Agents; Anticoagulation; Arrhythmia; Atrial Fibrillation; Award; Behavior Therapy; Biological; Biological Factors; Biological Markers; Biology; Cardiac; Cardiovascular Diseases; Caring; Cicatrix; Complex; Cross-Sectional Studies; Dedications; Diabetes Mellitus; Diagnosis; Disease; Evaluation; Fatigue; Fellowship; Foundations; Future; Gender; General Population; Goals; Health; Health Promotion; Heart; Heart Atrium; Heart Rate; Heart failure; Hypertension; Impairment; Incidence; Individual; Individual National Research Service Award; Inflammation; Intervention; Interview; Investigation; Knowledge; Left; Leptin; Life Style Modification; Link; Literature; Medical center; Metabolic; Methods; Myocardium; Nurses; Nursing Research; Obesity; Outcome; Palpitations; Participant; Pathway interactions; Patients; Personal Satisfaction; Persons; Population; Prevention; Procedures; Qualitative Methods; Quality of life; Reporting; Research; Research Training; Risk; Risk Factors; Role; Sampling; School Nursing; Scientist; Shortness of Breath; Signal Transduction; Sinus; Social Environment; Social Network; Social Perception; Social support; Structure; Symptoms; Tissues; Training; Universities; Visceral fat; Washington; Woman; adipokines; adiponectin; biobehavior; cardiac magnetic resonance imaging; comorbidity; cytokine; design; disabling symptom; doctoral student; experience; gender difference; health determinants; heart rhythm; imaging modality; inflammatory marker; innovation; lens; men; mortality risk; novel; pre-doctoral; programs; reduce symptoms; response; social; social factors; stroke risk; study population; symptomatic improvement

PROJECT SUMMARY The purpose of this Ruth L. Kirschstein National Research Service Award (NRSA) Individual Pre-Doctoral Fellowship in Nursing Research (F31) application is to provide research training for Ms. Frazier, a third-year doctoral student at the University of Washington School of Nursing. The long-term goal of this training is for this applicant to develop into an independent nurse scientist in a research-intensive academic setting with a program of research dedicated to interventions that integrate biological and socioecological factors to reduce and ameliorate symptom burden in individuals living with atrial fibrillation (AF). As the U.S. population ages, the number of individuals with AF is rapidly increasing, with cases projected to more than double by 2030. Most individuals with AF experience bothersome and at times debilitating symptoms that significantly impair quality of life (QOL). Women with AF bear the burden of more frequent and severe AF symptoms and lower QOL. While prior studies have consistently identified gender differences in AF symptom and QOL outcomes, the multilevel factors contributing to such differences in women and men are largely understudied. The applicant proposes a cross-sectional study (N=124) that employs both quantitative (Aims 1 and 2) and qualitative (Aim 3) methods to elucidate social factors and novel biological markers that contribute to differences in AF symptoms and QOL in women and men with AF. The specific aims are to: 1) Compare epicardial adipose tissue volume, adipokines (leptin and adiponectin), AF symptoms, and QOL between women and men with AF; 2) Examine for associations linked to potential intermediating pathways between epicardial adipose tissue volume, adipokines (leptin and adiponectin), AF symptoms, and QOL for women and men with AF; and 3) Explore perceptions of social factors (social support, living situation, and social network interactions) and their influence on AF symptoms and QOL for women and men with AF. Through advanced coursework and direct research experience, qualitative and quantitative methods, focused analysis of gender and social contexts in AF, and discovery of highly relevant links among biological markers of and AF-related outcomes, this award will provide a firm foundation for the long-term goal to develop behavioral interventions and upstream solutions to improve symptom experiences and QOL in women and men with AF.

项目摘要 这个Ruth L的目的。Kirschstein国家研究服务奖（NRSA）个人博士预科 Fellowship in Nursing Research（F31）申请是为了给Frazier女士提供研究培训，她是一名三年级的学生。 他是华盛顿大学护理学院的博士生。本次培训的长期目标是 本申请人在研究密集型学术环境中发展成为独立的护士科学家， 一个研究计划，致力于整合生物和社会生态因素，以减少 并改善患有心房颤动（AF）的个体的症状负担。随着美国人口老龄化， AF患者人数正在迅速增加，预计到2030年病例将增加一倍以上。最 AF患者会经历令人烦恼的症状，有时会出现严重损害质量的衰弱症状 生活（QOL）女性房颤患者的房颤症状更频繁、更严重，生活质量更低。 虽然先前的研究一致确定了AF症状和QOL结局的性别差异， 造成男女之间这种差异的多层面因素基本上没有得到充分研究。申请人 提出了一项采用定量（目标1和2）和定性（目标3）的横断面研究（N=124） 阐明导致房颤症状差异的社会因素和新生物学标志物的方法 和QOL。具体目的是：1）比较心外膜脂肪组织体积， 脂肪因子（瘦素和脂联素），AF症状，以及女性和男性AF患者之间的QOL; 2）检查 对于与心外膜脂肪组织体积之间的潜在中间途径相关的关联， 脂肪因子（瘦素和脂联素）、AF症状和AF患者的QOL;以及3）探索 对社会因素（社会支持、生活状况和社会网络互动）及其影响的看法 AF症状和生活质量的女性和男性AF。通过先进的课程和直接研究 经验，定性和定量方法，重点分析AF中的性别和社会背景，以及 发现生物标志物和AF相关结果之间高度相关的联系，该奖项将提供 为制定行为干预措施和上游解决方案的长期目标奠定坚实的基础， 女性和男性房颤患者的症状体验和生活质量。