BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS

血流动力学参数，如心率、动脉血压 每搏输出量在每搏基础上波动， 持续扰动与气候变化之间的动态相互作用 心血管系统和调节系统的反应。 心跳间变异性的数学分析已经显示 以前提供一种非侵入性的评估方法， 心血管系统闭环调节的完整性 系统 例如，心率变异性的频谱分析 已经显示出提供了副交感神经的非侵入性测量， 和β-交感神经活动 在本提案中，我们计划研究 血液动力学参数的自发性搏动间变异性 对应用于呼吸系统的宽带扰动的响应 活动、心率和动脉血压。 这些研究 将在犬和人中进行，以确定 控制血流动力学搏动间变异性的机制 参数 血流动力学参数变异性异常 将在病理生理条件下确定， 心血管调节，如心力衰竭和高血压。 一个心跳到心跳心血管调节的计算机模型将在 旨在阐明血流动力学变异性的机制 参数，并综合实验研究的结果。 最后，将开发新的临床诊断方法， 以敏感和定量的方法识别调节功能障碍， 方式

Hemodynamic parameters such as heart rate, arterial blood pressure stroke volume fluctuate on a beat-to-beat basis as a result of the dynamic interplay between ongoing perturbations to the cardiovascular system and the response of the regulatory systems. Mathematical analysis of beat-to-beat variability has been shown previously to provide a noninvasive means of assessing the integrity of the closed loop regulation of the cardiovascular system. For example, spectral analysis of heart rate variability has been shown to provide a noninvasive measure of parasympathetic and beta-sympathetic activity. In this proposal we plan to study spontaneous beat-to-beat variability in hemodynamic parameters in response to broad-band perturbations applied to respiratory activity, heart rate and arterial blood pressure. These studies will be conducted in the dog and in man to define the regulatory mechanisms governing beat-to-beat variability in hemodynamic parameters. Abnormalities in hemodynamic parameter variability will be identified in pathophysiological conditions affecting cardiovascular regulation such as heart failure and hypertension. A computer model of beat-to-beat cardiovascular regulation will be developed to elucidate mechanisms of variability in hemodynamic parameters and synthesize the results of the experimental studies. Finally, new clinical diagnostic methods will be developed to identify regulatory dysfunction in a sensitive and quantitative manner.