BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS

血流动力学参数，如心率、动脉血压 笔划量在节拍的基础上波动，这是由于 持续的扰动之间的动态相互作用 心血管系统和调节系统的反应。 对节拍之间的变异性进行了数学分析 以前提供了一种非侵入性的方法来评估 心血管闭环系统调节的完整性 系统。例如，心率变异性的频谱分析 已经被证明提供了一种非侵入性的副交感神经 以及β-交感神经活动。在这项提案中，我们计划研究 心脏自发性搏动变异性的血流动力学参数 对宽带扰动的响应应用于呼吸系统 活动、心率和动脉血压。这些研究 将在狗和人身上进行的监管定义 血流动力学中搏动变异性的调控机制 参数。血流动力学参数变异性异常 将在病理生理条件下被鉴定为影响 心血管调节，如心力衰竭和高血压。 一种节拍心血管调节的计算机模型将是 旨在阐明血流动力学中的变异性机制 参数，并综合实验研究的结果。 最后，将开发新的临床诊断方法，以 在敏感和定量的情况下识别监管功能障碍 举止。

Hemodynamic parameters such as heart rate, arterial blood pressure stroke volume fluctuate on a beat-to-beat basis as a result of the dynamic interplay between ongoing perturbations to the cardiovascular system and the response of the regulatory systems. Mathematical analysis of beat-to-beat variability has been shown previously to provide a noninvasive means of assessing the integrity of the closed loop regulation of the cardiovascular system. For example, spectral analysis of heart rate variability has been shown to provide a noninvasive measure of parasympathetic and beta-sympathetic activity. In this proposal we plan to study spontaneous beat-to-beat variability in hemodynamic parameters in response to broad-band perturbations applied to respiratory activity, heart rate and arterial blood pressure. These studies will be conducted in the dog and in man to define the regulatory mechanisms governing beat-to-beat variability in hemodynamic parameters. Abnormalities in hemodynamic parameter variability will be identified in pathophysiological conditions affecting cardiovascular regulation such as heart failure and hypertension. A computer model of beat-to-beat cardiovascular regulation will be developed to elucidate mechanisms of variability in hemodynamic parameters and synthesize the results of the experimental studies. Finally, new clinical diagnostic methods will be developed to identify regulatory dysfunction in a sensitive and quantitative manner.