BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS
BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS
批准号:
3356054
负责人:
RICHARD J COHEN
金额:
$33.16万
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-04-01 至 1994-03-31
关键词:
Parkinson's disease baroreceptors biological models blood pressure cardiovascular disorder cardiovascular disorder diagnosis cardiovascular pharmacology cardiovascular system computer data analysis congestive heart failure diabetic angiopathy dogs heart innervation heart rate hemodynamics human subject hypertension model design /development neural information processing parasympathetic nervous system postural hypotension pulmonary respiration renin angiotensin system sympathetic nervous system syndrome vagus nerve vascular resistance
中文摘要
血流动力学参数,如心率、动脉血压
每搏输出量在每搏基础上波动,
持续扰动与气候变化之间的动态相互作用
心血管系统和调节系统的反应。
心跳间变异性的数学分析已经显示
以前提供一种非侵入性的评估方法,
心血管系统闭环调节的完整性
系统 例如,心率变异性的频谱分析
已经显示出提供了副交感神经的非侵入性测量,
和β-交感神经活动 在本提案中,我们计划研究
血液动力学参数的自发性搏动间变异性
对应用于呼吸系统的宽带扰动的响应
活动、心率和动脉血压。 这些研究
将在犬和人中进行,以确定
控制血流动力学搏动间变异性的机制
参数 血流动力学参数变异性异常
将在病理生理条件下确定,
心血管调节,如心力衰竭和高血压。
一个心跳到心跳心血管调节的计算机模型将在
旨在阐明血流动力学变异性的机制
参数,并综合实验研究的结果。
最后,将开发新的临床诊断方法,
以敏感和定量的方法识别调节功能障碍,
方式
英文摘要
Hemodynamic parameters such as heart rate, arterial blood pressure
stroke volume fluctuate on a beat-to-beat basis as a result of the
dynamic interplay between ongoing perturbations to the
cardiovascular system and the response of the regulatory systems.
Mathematical analysis of beat-to-beat variability has been shown
previously to provide a noninvasive means of assessing the
integrity of the closed loop regulation of the cardiovascular
system. For example, spectral analysis of heart rate variability
has been shown to provide a noninvasive measure of parasympathetic
and beta-sympathetic activity. In this proposal we plan to study
spontaneous beat-to-beat variability in hemodynamic parameters in
response to broad-band perturbations applied to respiratory
activity, heart rate and arterial blood pressure. These studies
will be conducted in the dog and in man to define the regulatory
mechanisms governing beat-to-beat variability in hemodynamic
parameters. Abnormalities in hemodynamic parameter variability
will be identified in pathophysiological conditions affecting
cardiovascular regulation such as heart failure and hypertension.
A computer model of beat-to-beat cardiovascular regulation will be
developed to elucidate mechanisms of variability in hemodynamic
parameters and synthesize the results of the experimental studies.
Finally, new clinical diagnostic methods will be developed to
identify regulatory dysfunction in a sensitive and quantitative
manner.
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会议论文
Oxidants, Eicosanoids and Endothelium in Diabetes
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批准号:6999137
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项目类别:
-
资助金额:$41.27万
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财政年份:2004
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负责人:RICHARD J COHEN
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依托单位:
CARDIOVASCULAR SYSTEM IDENTIFICATION--INFLUENCE OF BODY POSITION
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批准号:6246679
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项目类别:
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资助金额:$6.54万
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财政年份:1997
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负责人:RICHARD J COHEN
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依托单位:
CLOSED-LOOP ANALYSIS OF BAROREFLEX SENSITIVITY
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批准号:6246680
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项目类别:
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资助金额:$6.54万
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财政年份:1997
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负责人:RICHARD J COHEN
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依托单位:
CARDIOVASCULAR SYSTEM IDENTIFICATION--EFFECT OF AUTONOMIC BLOCKADE
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批准号:6246687
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项目类别:
-
资助金额:$6.54万
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财政年份:1997
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负责人:RICHARD J COHEN
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依托单位:
BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS
-
批准号:3356059
-
项目类别:
-
资助金额:$32.64万
-
财政年份:1989
-
负责人:RICHARD J COHEN
-
依托单位:
BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS
-
批准号:3356057
-
项目类别:
-
资助金额:$29.65万
-
财政年份:1989
-
负责人:RICHARD J COHEN
-
依托单位:
BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS
-
批准号:3356056
-
项目类别:
-
资助金额:$29.33万
-
财政年份:1989
-
负责人:RICHARD J COHEN
-
依托单位:
BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS
-
批准号:3356058
-
项目类别:
-
资助金额:$30.84万
-
财政年份:1989
-
负责人:RICHARD J COHEN
-
依托单位:
Oxidants, Eicosanoids and Endothelium in Diabetes
-
批准号:7441021
-
项目类别:
-
资助金额:$42.38万
-
财政年份:--
-
负责人:RICHARD J COHEN
-
依托单位:
Oxidants, Eicosanoids and Endothelium in Diabetes
-
批准号:7441025
-
项目类别:
-
资助金额:$46.38万
-
财政年份:--
-
负责人:RICHARD J COHEN
-
依托单位:
Oxidants, Eicosanoids and Endothelium in Diabetes
-
批准号:7441017
-
项目类别:
-
资助金额:$42.32万
-
财政年份:--
-
负责人:RICHARD J COHEN
-
依托单位:
CARDIOVASCULAR SYSTEM IDENTIFICATION--INFLUENCE OF BODY POSITION
-
批准号:5219353
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARD J COHEN
-
依托单位:--
海外基金