BARORECEPTORS AND HORMONES IN THIRST AND SALT APPETITE

口渴和盐食欲中的压力感受器和激素

• 批准号: 6165052
• 负责人: ROBERT L THUNHORST
• 金额: $ 10.74万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6165052
• 关键词: angiotensins; appetite; baroreceptors; blood pressure; carotid body; denervation; hypovolemia; kidney function; laboratory rat; nutrition related tag; salt intake; thirst

DESCRIPTION: The present proposal builds upon the investigator's prior investigations of fluid-related afferent signaling and central processing. The proposed research will employ recently developed models in the rat that permit the investigation of interactive hormonal (angiotensin) and the neural (arterial and cardiopulmonary baroreceptor) afferent signals that control hypovolemic thirst and salt appetite. Preliminary experiments demonstrate that decreases and increases in arterial pressure [AP] respectively facilitate and inhibit water drinking induced by intraventricular angiotensin II. Part 1 of the proposal examines modulatory effects of arterial pressure [AP] on the generation of salt appetite following acute sodium depletion. A second series of preliminary experiments demonstrate that rats lacking arterial baroreceptor input to the brain after surgical removal of the relevant nerves (i.e., denervation of the carotid sinus and aortic arch baroreceptors) have impaired salt intakes in two experimental models of sodium depletion-induced salt appetite that rely largely on the actions of ANG II to produce the salt appetite. Part 2 of this proposal extend this line of investigation to the contributions of another set of vascular neural sensors, i.e. cardiopulmonary baroreceptors, to the salt appetite that follows sodium depletion. A recent, third series of studies has implicated the renal nerves in the production of salt appetite following extracellular fluid depletion. Part 3 of this proposal will continue this research to determine if renal afferent or efferent nerves provide the basis for this phenomenon.

描述：本提案建立在调查员之前的基础上 流体相关传入信号和中枢神经系统的研究 正在处理。拟议的研究将使用最近开发的模型 在允许研究相互作用荷尔蒙的大鼠中 (血管紧张素)和神经(动脉和心肺压力感受器) 控制低血容性口渴和食盐胃口的传入信号。 初步实验表明，在 动脉压[AP]分别促进和抑制水分 脑室血管紧张素诱发饮酒II.第一部分 Proposal研究了动脉压[AP]对血压的调节作用 急性钠耗竭后产生食盐欲望。一秒钟 一系列初步实验表明，缺乏动脉的大鼠 压力感受器在手术切除相关脑区后输入大脑 神经(即颈动脉窦和主动脉弓的失神经 压力感受器)在两个实验模型中损害了盐的摄取 钠耗竭引起的食盐欲望在很大程度上依赖于 血管紧张素II来产生食盐的胃口。此提案的第2部分将扩展 这项调查对另一组 血管神经感受器，即心肺压力感受器 钠耗尽后的食欲。最近的，第三个系列 研究表明肾神经与盐的产生有关。 细胞外液耗尽后的食欲。本文的第三部分 提案将继续这项研究，以确定肾传入或 传出神经为这一现象提供了基础。

项目成果

Fos expression in rat brain during depletion-induced thirst and salt appetite.

• DOI: 10.1152/ajpregu.1998.274.6.r1807
• 发表时间: 1998-06
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: R. Thunhorst;Zhice Xu;M. Cicha;A. Zardetto-Smith;A. K. Johnson

Effect of hyperosmotic solutions on salt excretion and thirst in rats.

高渗溶液对大鼠盐排泄和口渴的影响。

• DOI: 10.1152/ajpregu.2000.278.4.r917
• 发表时间: 2000
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Schoorlemmer,GH;Johnson,AK;Thunhorst,RL
• 通讯作者: Thunhorst,RL

Circulating angiotensin II mediates sodium appetite in adrenalectomized rats.

• DOI: 10.1152/ajpregu.2001.281.3.r723
• 发表时间: 2001-09
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: G. Schoorlemmer;A. K. Johnson;R. Thunhorst

Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite.

低血压和液体缺乏对中枢血管紧张素引起的口渴和盐食欲的影响。

• DOI: 10.1152/ajpregu.2001.281.5.r1726
• 发表时间: 2001
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Thunhorst,RL;Johnson,AK
• 通讯作者: Johnson,AK

Increased cellular activity in rat insular cortex after water and salt ingestion induced by fluid depletion.

• DOI: 10.1152/ajpregu.00189.2002
• 发表时间: 2003-04
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Cinthia V. Pastuskovas;M. Cassell;A. Johnson;R. Thunhorst