Histological studies on the relationship between the baroreceptors in the eye and glaucomatous changes

眼部压力感受器与青光眼变化关系的组织学研究

• 批准号: 23659820
• 负责人: OGINO Dai
• 金额: $ 2.08万
• 依托单位: Akita University (2012-2013)Showa University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659820/
• 关键词: 緑内障モデル動物; TRPV-1; カプサイシン; TRPV1; ラット緑内障モデル; なし; 眼組織学; 緑内障

The purpose of this experiment is to investigate the relationship between capsaicin-sensitive sensory nerve or transient receptor potential vanilloid 1 (TRPV-1) and glaucomatous changes. The eyes of the animal model of glaucoma did not show any difference of TRPV-1 like immunoreactivity from the control rat eyes. The effect of capsaicin denervation was also studied. Fourteen days after eyelids opened, the newborn rat treated with 55 mg/kg capsaicin showed the IOP elevation, 20 - 42 mmHg. These eyes were enlarged. It was unclear if the result was caused only by the effect of capsaicin denervation. These capsaicin treated rats were insulted by the ligation of the episcleral vein to elevate intraocular pressure. The histological difference from normal rat glaucoma model was not detected.

本实验旨在探讨辣椒素敏感感觉神经或瞬时受体电位香草素1(TRPV-1)与青光眼改变的关系。青光眼动物模型组大鼠眼内TRPV-1免疫反应与对照眼无明显差异。并对辣椒素的去神经作用进行了研究。睁开眼皮14天后，给予55 mg/kg辣椒素的新生大鼠眼压升高20-42毫米汞柱。这些眼睛都放大了。目前还不清楚这一结果是否只是由辣椒素去神经作用引起的。这些辣椒素处理的大鼠通过结扎巩膜上静脉来升高眼压。未检测到与正常大鼠青光眼模型的组织学差异。