CORONARY RESERVE AND CORONARY DYNAMICS

据报道，运动训练有益于预防和/或 治疗冠心病。 然而，主要的基础 机制和相对重要性的训练引起的变化， 此时冠状动脉血管床尚不清楚。 的主要目标 本提案中概述的研究旨在更好地了解 运动训练对基础冠脉功能的影响。 以来 冠状动脉循环的目的是运输营养和氧气， 心肌细胞并将代谢物从这些细胞中运输出去， 这项资助主要用于研究训练对冠状动脉运输的影响 容量 在这项补助金的第一年，发现冠状动脉 通过测量冠状动脉血流量， 储备能力和冠脉毛细血管弥散能力。 就在那时 研究发现，经过锻炼的狗的冠状动脉 血液流动中运输储备和毛细血管扩散能力 两者都增加了。 本提案中概述的研究将达到5 具体目标，这些目标将决定负责和 此变更的功能意义： 1.确定负责运动训练诱导的机制 冠状动脉运输储备增加。 2.确定交感神经系统在运动中的作用 训练引起冠状动脉运输储备增加。 3.确定运动训练如何引起冠状动脉的变化， 血管床影响急性心肌缺血时毛细血管运输。 4.确定运动训练对冠状动脉转运储备的影响 小型猪 5.确定训练如何诱导冠状动脉转运增加 储备影响冠状动脉跨毛细血管交换和交换能力 有意识的狗。 将使用多指标测量经肩胛骨交换 扩散技术 冠状动脉血流量将在清醒和 麻醉狗用电磁流量计。 局部冠脉 血流量和总血流量异质性将用 放射性标记微球技术。

Exercise training has been reported to be beneficial in preventing and/or treating coronary heart disease. However, the primary underlying mechanisms and the relative importance of training induced changes in the coronary vascular bed are not clear at this time. The major goal of the research outlined in this proposal is to provide a better understanding of the effects of exercise training on basic coronary function. Since the purpose of the coronary circulation is to transport nutrients and oxygen to the myocardial cells and to transport metabolites away from these cells, this grant focuses on the effects of training on coronary transport capacity. During the first year of this grant it was found that coronary transport capacity can be quantitated by measuring coronary blood flow reserve capacity and coronary capillary diffusion capacity. It was then found that exercise trained dogs have a large increase in coronary transport reserve in that blood flow and capillary diffusion capacities are both increased. The research outlined in this proposal will attain 5 specific aims that will determine the mechanisms responsible for and functional significance of this change: 1. Determine the mechanisms responsible for the exercise training induced increase in coronary transport reserve. 2. Determine the role of the sympathetic nervous system in the exercise training induced increase in coronary transport reserve. 3. Determine how the exercise training induced changes in the coronary vascular bed influence capillary transport during acute myocardial ischemia. 4. Determine the effects of exercise training on coronary transport reserve in minature swine. 5. Determine how the training induced increase in coronary transport reserve influences coronary transcapillary exchange and exchange capacity in conscious dogs. Transcapillary exchange will be measured with the multiple indicator diffusion technique. Coronary blood flow will be measured in conscious and anesthetized dogs with electromagnetic flow meters. Regional coronary blood flow and gross blood flow heterogeneity will be determined with the radiolabeled microsphere technique.