Cardiovascular Molecular/Cellular Biology

描述（由申请人提供）：根据美国心脏协会，三分之一的美国成年人患有心血管疾病（CVD）（超过8000万成年人），世界卫生组织指出心血管疾病是全球第一大死亡原因。因此，尽管心血管疾病的治疗取得了重大进展，但它仍然是我国和世界上导致死亡的主要原因。密苏里大学（MU）的心血管健康和体育活动小组因揭示运动对心血管疾病有益作用的分子、生化和生理机制而获得了全国的认可。目前的应用程序将通过增加分子/细胞生物学家来建立这一优势，从而改善最先进的心血管过程分子、生化和生理评估的整合。新教员将被纳入四个心血管研究小组：1)心肌，2)血管生物学和运动，3)微血管生物学和成像，4)神经-体液心血管控制，这些都被整合到几个系的长期培训项目中。新聘用的教员将能够指导来自几个单元的研究生。职业发展由高级研究人员组成的指导委员会促进，该委员会为职业决策、研究审查、资助和手稿制定提供资源。在这个校园里，鼓励部门和部门之间的密切互动。心血管细胞/分子生物学家的加入将建立在心血管科学的卓越跨学科研究基础上，并进一步将MU建立为美国首屈一指的运动和心血管健康研究和培训中心。该教师将使用分子生物学和基因调控来研究心血管疾病的基础，从而形成合作联系，从而促进他们的职业发展。心血管科学小组的优秀研究骨干，加上这位新教员，将在揭示心血管疾病预防和治疗的基本机制方面达到更高的水平。

DESCRIPTION (provided by applicant): According to the American Heart Association, 1 in 3 American adults has cardiovascular disease (CVD) (over 80 million adults) and the WHO indicates that CVD is the number 1 cause of death worldwide. Thus despite major advances in treatment of CVD, it remains the leading cause of death in our nation and the world. The Cardiovascular Health and Physical Activity group here at University of Missouri (MU) has attracted national recognition for work revealing molecular, biochemical and physiological mechanisms underlying the beneficial effects of exercise on CVD. This current application will build on this strength by adding a molecular/cellular biologist and thereby improve integration of state-of the-art molecular, biochemical and physiological assessments of cardiovascular processes. The new faculty member will fit into one of four groups of cardiovascular researchers: 1) Cardiac Muscle. 2) Vascular Biology and Exercise. 3) Microvascular Biology and Imaging. 4) Neural-humoral Cardiovascular Control that are integrated into long-standing training programs in several departments. The newly-hired faculty member will be able to mentor graduate students from several units. Career development is fostered by a mentoring committee of senior investigators who serve as a resource for career decision, research review and grant and manuscript formulation. Intense interactions across departmental and divisional lines are encouraged and routine on this campus. The addition of a cardiovascular cellular/molecular biologist will build on the interdisciplinary research excellence in cardiovascular sciences and further establish MU as a premiere research and training center in the U.S. for Exercise and Cardiovascular Health. This faculty member will examine the basis of CVD using molecular biology, and gene regulation and as a result form collaborative links that will enhance their career development. The outstanding cadre of investigators here in the cardiovascular sciences group, combined with this new faculty member will attain an even higher level of national preeminence reveal fundamental mechanisms in prevention and treatment of CVD. Cardiovascular researchers at MU are at the forefront of research concerning the effects of exercise/physical activity on cardiovascular disease. This is a proposal to hire a researcher with training and interests in molecular biology, and gene regulation focused on the importance of exercise/ physical activity in preventing cardiovascular disease. This will create a new faculty position and add 1 or 2 research staff positions. These faculty, combined with the new faculty member, will reveal fundamental mechanisms in how muscle activity/exercise contribute to prevention and treatment of cardiovascular disease