Cardiovascular Molecular/Cellular Biology

描述(申请人提供)：根据美国心脏协会的数据，每3名美国成年人中就有1人患有心血管疾病(超过8000万成年人)，世界卫生组织指出，心血管疾病是全球头号死因。因此，尽管在治疗心血管疾病方面取得了重大进展，但它仍然是我国和世界上主要的死亡原因。密苏里大学(MU)的心血管健康和体力活动小组因揭示了运动对心血管疾病有益影响的分子、生化和生理机制而受到全国认可。目前的这一应用将通过增加一名分子/细胞生物学家来加强这一优势，从而改善对心血管过程的最先进的分子、生化和生理评估的集成。这位新的教员将属于心血管研究人员的四个小组之一：1)心肌。2)血管生物学与运动。3)微血管生物学与影像学。4)神经体液心血管控制，整合到多个科室的长期培训计划中。这位新聘用的教员将能够指导来自几个单位的研究生。职业发展由一个由高级调查人员组成的指导委员会促进，该委员会作为职业决定、研究审查和拨款以及手稿制定的资源。在这个校园里，跨部门和分部的激烈互动是鼓励和例行公事的。增加一名心血管细胞/分子生物学家将建立在心血管科学跨学科研究的卓越基础上，并进一步将墨尔本大学打造为美国一流的运动和心血管健康研究和培训中心。这位教员将使用分子生物学和基因调控来研究心血管疾病的基础，并因此形成合作链接，促进他们的职业发展。心血管科学组的优秀研究干部，加上这位新的教职员工，将达到更高水平的全国卓越水平，揭示心血管疾病预防和治疗的基本机制。 密歇根大学的心血管研究人员处于运动/体力活动对心血管疾病影响的研究前沿。这是一项建议，聘请一名在分子生物学和基因调控方面受过培训和感兴趣的研究人员，重点关注锻炼/体力活动在预防心血管疾病方面的重要性。这将创造一个新的教职员工职位，并增加1到2个研究人员职位。这些教员与新教员一起，将揭示肌肉活动/锻炼如何有助于预防和治疗心血管疾病的基本机制。

DESCRIPTION (provided by applicant): According to the American Heart Association, 1 in 3 American adults has cardiovascular disease (CVD) (over 80 million adults) and the WHO indicates that CVD is the number 1 cause of death worldwide. Thus despite major advances in treatment of CVD, it remains the leading cause of death in our nation and the world. The Cardiovascular Health and Physical Activity group here at University of Missouri (MU) has attracted national recognition for work revealing molecular, biochemical and physiological mechanisms underlying the beneficial effects of exercise on CVD. This current application will build on this strength by adding a molecular/cellular biologist and thereby improve integration of state-of the-art molecular, biochemical and physiological assessments of cardiovascular processes. The new faculty member will fit into one of four groups of cardiovascular researchers: 1) Cardiac Muscle. 2) Vascular Biology and Exercise. 3) Microvascular Biology and Imaging. 4) Neural-humoral Cardiovascular Control that are integrated into long-standing training programs in several departments. The newly-hired faculty member will be able to mentor graduate students from several units. Career development is fostered by a mentoring committee of senior investigators who serve as a resource for career decision, research review and grant and manuscript formulation. Intense interactions across departmental and divisional lines are encouraged and routine on this campus. The addition of a cardiovascular cellular/molecular biologist will build on the interdisciplinary research excellence in cardiovascular sciences and further establish MU as a premiere research and training center in the U.S. for Exercise and Cardiovascular Health. This faculty member will examine the basis of CVD using molecular biology, and gene regulation and as a result form collaborative links that will enhance their career development. The outstanding cadre of investigators here in the cardiovascular sciences group, combined with this new faculty member will attain an even higher level of national preeminence reveal fundamental mechanisms in prevention and treatment of CVD. Cardiovascular researchers at MU are at the forefront of research concerning the effects of exercise/physical activity on cardiovascular disease. This is a proposal to hire a researcher with training and interests in molecular biology, and gene regulation focused on the importance of exercise/ physical activity in preventing cardiovascular disease. This will create a new faculty position and add 1 or 2 research staff positions. These faculty, combined with the new faculty member, will reveal fundamental mechanisms in how muscle activity/exercise contribute to prevention and treatment of cardiovascular disease