EXERCISE: CORONARY RESERVE, CORONARY HEART DISEASE

据报道，运动训练有益于预防和/或 治疗冠心病。然而，主要的基础是 训练引起的变化的机制和相对重要性 冠状动脉血管床目前尚不清楚。这次会议的主要目标是 本提案中概述的研究是为了更好地了解 运动训练对冠脉基础功能的影响。自.以来 冠状循环的目的是将营养物质和氧气输送到 并将代谢产物从这些细胞中转移出去， 这笔赠款的重点是训练对冠状动脉运输的影响。 容量。在这笔赠款的第一年，人们发现冠心病 运输能力可以通过测量冠脉血流量来定量 储备量和冠脉毛细血管扩散量。就在那时 发现经过运动训练的狗患冠状动脉疾病的几率大大增加 在血液流动和毛细血管扩散能力中运输储备 两者都增加了。这项提案中概述的研究将达到5 具体目标，将确定负责和 这一变化的功能意义： 1.确定运动训练诱导的机制 增加冠脉运输储备。 2.确定交感神经系统在运动中的作用 训练导致冠脉运输储备增加。 3.确定运动训练是如何引起冠状动脉改变的 急性心肌缺血时血管床影响毛细血管运输。 4.确定运动训练对冠状动脉运输储备的影响 在微型猪身上。 5.确定训练是如何导致冠状动脉运输增加的 储备对冠状动脉毛细血管交换和交换能力的影响 在有意识的狗身上。 用多项指示剂测量跨毛细管交换 扩散技术。冠脉血流量将在有意识和 用电磁流量计麻醉的狗。区域冠脉 血流量和总血流量的不均一性将通过 放射性标记微球技术。

Exercise training has been reported to be beneficial in preventing and/or treating coronary heart disease. However, the primary underlying mechanisms and the relative importance of training induced changes in the coronary vascular bed are not clear at this time. The major goal of the research outlined in this proposal is to provide a better understanding of the effects of exercise training on basic coronary function. Since the purpose of the coronary circulation is to transport nutrients and oxygen to the myocardial cells and to transport metabolites away from these cells, this grant focuses on the effects of training on coronary transport capacity. During the first year of this grant it was found that coronary transport capacity can be quantitated by measuring coronary blood flow reserve capacity and coronary capillary diffusion capacity. It was then found that exercise trained dogs have a large increase in coronary transport reserve in that blood flow and capillary diffusion capacities are both increased. The research outlined in this proposal will attain 5 specific aims that will determine the mechanisms responsible for and functional significance of this change: 1. Determine the mechanisms responsible for the exercise training induced increase in coronary transport reserve. 2. Determine the role of the sympathetic nervous system in the exercise training induced increase in coronary transport reserve. 3. Determine how the exercise training induced changes in the coronary vascular bed influence capillary transport during acute myocardial ischemia. 4. Determine the effects of exercise training on coronary transport reserve in minature swine. 5. Determine how the training induced increase in coronary transport reserve influences coronary transcapillary exchange and exchange capacity in conscious dogs. Transcapillary exchange will be measured with the multiple indicator diffusion technique. Coronary blood flow will be measured in conscious and anesthetized dogs with electromagnetic flow meters. Regional coronary blood flow and gross blood flow heterogeneity will be determined with the radiolabeled microsphere technique.