MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND

我们最近成功地制作了三维阴影 左心室腔的表面超声图像 人类使用一种新的方法传感器staqblization和旋转。 获得用于产生多维体积图像的DAA 通过递增地旋转扇形扫描器换能器通过180% 其中心波束以适当的声窗为中心。 记录了50个视角，供随后的选择， 心电图和呼吸的门控 然后， 从心脏中适当点的每个视图中选择， 呼吸循环并插入到三维体积中。 由此产生的imates承诺新的方法来分析复杂的 心脏和大血管的动态几何形状 工作站软件 这项提案是一个最大的， 最有经验的超声心动图实验室和一个活跃的， 超声波研究实验室。 生物动力学 超声实验室是研究单位的一部分， 一直在开发多维成像设备（如 Dynamic Spatial Reconstructor）和软件20多年。 这项工作的一个主要成果是分析一个广泛使用的 梅奥开发的多维数据nalaysis包。正是这种 在多维软件方面的丰富经验和开拓性的努力 在临床超声心动图中， 建议研究。 该提案包括四个目标。 首先，我们将完善我们的 多维扫描的方法，通过开发的方法， 传感器稳定、图像同步和图像 数字化和存储（在数字盒式磁带上）。 二是 将评估多维图像的保真度， 使用从新鲜固定心脏获得的数据计算参数 在水箱中，麻醉动物（也在DSR上扫描）， 选择志愿者和病人。 第三，我们将发展 用于临床特定分析和测量的先进软件 心肌结构和功能的超声图像 体积测量数据。 第四，使用ROC分析，我们将测试 数据采集的准确性和临床实用性， 分析工作站概念，使用专门选择的心脏 在大量的临床或手术中证实的病变 患者

We have recently successfully produced three-dimensional shaded surface ultrasound images of the left ventricular chamber of a human using a new method of transducer staqblization and rotation. Daa for producing multidimensional volumetric images were acquired by incrementally rotating a sector scanner transducer through 180% about its central beam centered at an appropriate acousic window. Fifty angles of view were recorded for subsequent selection by gating with the ECG and respiration. Sctor scan images were then selected from each view at appropriate points in the heart and respiratory cycles and inserted into a three-dimensional volume. The resulting imates promise new methods of analyzing complex dynamic geometries of the heart and great vessels using advanced workstation software. This proposal is a collaborative effort between one of the largest, most experienced echo cardiography laboratories and an active, widely knwon ultrasonic research laboratory. The Biodynamics Research Unit, of which the Ultrasound Laboratory is a part, has been developing multidimensional imaging devices (such as the Dynamic Spatial Reconstructor) and software for more than 20 years. One major result from this effort has been ANALYZE a widely used Mayo-developed multidimensional data nalaysis package. It is this vast experience in multidimensional software and pioneering efforts in clinical echocardiography that provide the expertise for this proposed reseach. The proposal consists of four aims. First, we will refine our methods of multidimensional scanning by developing methods of transducer stabilizaation, image synchronization, and image digitization and storage (on digital cassette tape). Second, we will evaluate the fidelity of the multidimensional images and calculated parameters using data obtained from fresh fixed hearts in a water tank, anesthetized animals (also scanned on the DSR), and selected volunteers and patients. Third, we will develop advanced software for cliniclly specific analysis and measurement of myocardial structure and function from the ultrasound vol.umetric data. Fourth, using ROC analysis, we will test the accuracy and clinical usefulness of the data acquisition and analysis workstation concept using specifically selected cardiac lesions proven clinically or surgically in a large number of patients.