STRESS, SODIUM, AND BLOOD PRESSURE REGULATION

压力、钠和血压调节

• 批准号: 3357341
• 负责人: GERALD F DIBONA
• 金额: $ 9.33万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3357341
• 关键词: alpha adrenergic agent; alpha antiadrenergic agent; blood; blood pressure; body water; central nervous system; dietary mineral; dietary potassium; dietary supplements; diuresis; efferent nerve; electrolyte balance; electrophysiology; guanidines; isotope dilution method; kidney circulation; kidney pharmacology; nutrition related tag; radiotracer; renal hypertension; salt intake; saluresis; sodium; stress; sympathetic nervous system; urine; yohimbine

The proposed research is designed to determine the physiological and pathophysiological factors involved in the interaction between dietary sodium intake and environmental stress in relation to the pathogenesis of hypertension. A major focus is that dietary sodium intake modulates the efferent renal sympathetic nerve activity (ERSNA) response to environmental stress and that the resultant changes in renal hemodynamic and excretory function contribute importantly to the development, maintenance and exacerbation of hypertension. Using techniques for measurements of ERSNA and renal function in conscious hypertensive rate models, the interaction between genetic and environmental (dietary sodium/potassium intake, environmental stress) factors will be examined. Specific Aim 1 will determine if the sensitivity of central nervous system alpha-2 adrenoceptors involved in the regulation of the ERSNA response to environmental stress is affected by changes in dietary sodium intake. Specific Aims 2 and 3 will determine if acute exposure to environmental stress increases ERSNA and decreases urinary sodium excretion in Dahl R/S and Borderline Hypertensive Rats (BHR). Specific Aim 4 will determine if high dietary sodium intake modulates the ERSNA and renal hemodynamic/excretory response to environmetal stress in BHR. Specific Aim 5 will determine if the enhanced ERSNA and renal hemodynamic/excretory responses to environmental stress in SHR on a high dietary sodium intake are dependent on increases in total body sodium and fluid volumes. Specific Aim 6 will determine if dietary potassium supplementation modulates the ERSNA and renal hemodynamic/excretory responses to environmental stress in experimental forms of hypertension.

拟议的研究旨在确定生理学 和病理生理因素之间的相互作用 膳食钠摄入量与环境压力的关系 高血压的发病机制。 一个主要关注点是饮食 钠摄入量调节传出肾交感神经 活动（ERSNA）对环境压力的反应，并且 肾血流动力学和排泄功能的变化 为开发、维护和维护做出重要贡献 高血压恶化。 使用测量技术 ERSNA 与肾功能对清醒高血压发生率的影响 模型，遗传与环境之间的相互作用 （膳食钠/钾摄入量、环境压力）因素 将接受检查。 具体目标 1 将确定灵敏度是否 中枢神经系统 α-2 肾上腺素受体参与 ERSNA 对环境压力响应的调节是 受膳食钠摄入量变化的影响。 具体目标2 3 将确定是否急性暴露于环境压力 增加 ERSNA 并减少 Dahl 尿钠排泄 R/S 和临界高血压大鼠 (BHR)。 具体目标 4 将 确定高膳食钠摄入量是否会调节 ERSNA 和 肾血流动力学/排泄对环境应激的反应 渤海华美。 具体目标 5 将确定增强型 ERSNA 和 肾脏血流动力学/排泄对环境应激的反应 在 SHR 中，高膳食钠摄入量取决于增加 体内钠总量和液体总量。 具体目标 6 将 确定膳食钾补充剂是否调节 ERSNA 和肾脏血流动力学/排泄反应 实验形式的高血压中的环境压力。