STRESS, SODIUM, AND BLOOD PRESSURE REGULATION

这项拟议的研究旨在确定生理上的 以及参与相互作用的病理生理因素 膳食钠摄入量和环境应激与健康的关系 高血压的发病机制。一个主要的焦点是饮食 钠摄入量对传出肾交感神经的调节作用 活动(ERSNA)对环境压力的反应 由此引起的肾脏血流动力学和排泄功能的变化 对开发、维护和 高血压的恶化。使用技术进行测量 清醒高血压患者ERSNA与肾功能的关系 模型，遗传和环境之间的相互作用 (膳食钠/钾摄入量、环境应激)因素 将会被检查。具体目标1将决定是否敏感性 中枢神经系统α-2肾上腺素能受体参与 调节ERSNA对环境应激的反应是 受饮食钠摄入量变化的影响。具体目标2 和3将确定急性暴露在环境压力下 DAHL患者增加ERSNA和减少尿钠排泄 R/S和临界高血压大鼠。具体目标4将 确定高膳食钠摄入量是否调节ERSNA和 肾血流动力学/排泄反应对环境金属应激的影响 Bhr.具体目标5将确定增强的ERSNA和 肾脏血流动力学/排泄对环境应激的反应 在自发性高血压患者中，高钠饮食摄入量依赖于增加 体内的钠和液体总量。特定目标6将 确定膳食补钾是否调节 ERSNA与肾血流动力学/排泄反应 高血压实验形式中的环境应激。

The proposed research is designed to determine the physiological and pathophysiological factors involved in the interaction between dietary sodium intake and environmental stress in relation to the pathogenesis of hypertension. A major focus is that dietary sodium intake modulates the efferent renal sympathetic nerve activity (ERSNA) response to environmental stress and that the resultant changes in renal hemodynamic and excretory function contribute importantly to the development, maintenance and exacerbation of hypertension. Using techniques for measurements of ERSNA and renal function in conscious hypertensive rate models, the interaction between genetic and environmental (dietary sodium/potassium intake, environmental stress) factors will be examined. Specific Aim 1 will determine if the sensitivity of central nervous system alpha-2 adrenoceptors involved in the regulation of the ERSNA response to environmental stress is affected by changes in dietary sodium intake. Specific Aims 2 and 3 will determine if acute exposure to environmental stress increases ERSNA and decreases urinary sodium excretion in Dahl R/S and Borderline Hypertensive Rats (BHR). Specific Aim 4 will determine if high dietary sodium intake modulates the ERSNA and renal hemodynamic/excretory response to environmetal stress in BHR. Specific Aim 5 will determine if the enhanced ERSNA and renal hemodynamic/excretory responses to environmental stress in SHR on a high dietary sodium intake are dependent on increases in total body sodium and fluid volumes. Specific Aim 6 will determine if dietary potassium supplementation modulates the ERSNA and renal hemodynamic/excretory responses to environmental stress in experimental forms of hypertension.