STRESS, SODIUM, AND BLOOD PRESSURE REGULATION

这项研究旨在确定 和病理生理因素参与的相互作用， 膳食钠摄入量和环境压力与 高血压的发病机制 一个主要的焦点是饮食 钠摄入调节传出肾交感神经 活动（ERSNA）对环境压力的反应， 肾血流动力学和排泄功能的变化 为发展、维护和 高血压加重。 使用测量技术 有意识高血压患者ERSNA与肾功能的关系 模型，遗传和环境之间的相互作用 （膳食钠/钾摄入量、环境压力）因素 将被审查。 具体目标1将确定灵敏度是否 中枢神经系统α-2肾上腺素受体参与 调节ERSNA对环境压力的反应， 受饮食中钠摄入量变化的影响。 具体目标2 第三项将确定急性暴露于环境压力 Dahl增加ERSNA并减少尿钠排泄 R/S和边界高血压大鼠（BHR）。 具体目标4将 确定高膳食钠摄入是否调节ERSNA， 肾血流动力学/排泄反应的金属应激， BHR。 具体目标5将确定增强的经济资源核算体系和 肾血流动力学/排泄对环境应激的反应 在SHR中，高膳食钠摄入量依赖于增加 体内钠和液体总量的变化 具体目标6将 确定膳食钾补充剂是否调节 ERSNA和肾血流动力学/排泄反应 高血压实验中的环境压力。

The proposed research is designed to determine the physiological and pathophysiological factors involved in the interaction between dietary sodium intake and environmental stress in relation to the pathogenesis of hypertension. A major focus is that dietary sodium intake modulates the efferent renal sympathetic nerve activity (ERSNA) response to environmental stress and that the resultant changes in renal hemodynamic and excretory function contribute importantly to the development, maintenance and exacerbation of hypertension. Using techniques for measurements of ERSNA and renal function in conscious hypertensive rate models, the interaction between genetic and environmental (dietary sodium/potassium intake, environmental stress) factors will be examined. Specific Aim 1 will determine if the sensitivity of central nervous system alpha-2 adrenoceptors involved in the regulation of the ERSNA response to environmental stress is affected by changes in dietary sodium intake. Specific Aims 2 and 3 will determine if acute exposure to environmental stress increases ERSNA and decreases urinary sodium excretion in Dahl R/S and Borderline Hypertensive Rats (BHR). Specific Aim 4 will determine if high dietary sodium intake modulates the ERSNA and renal hemodynamic/excretory response to environmetal stress in BHR. Specific Aim 5 will determine if the enhanced ERSNA and renal hemodynamic/excretory responses to environmental stress in SHR on a high dietary sodium intake are dependent on increases in total body sodium and fluid volumes. Specific Aim 6 will determine if dietary potassium supplementation modulates the ERSNA and renal hemodynamic/excretory responses to environmental stress in experimental forms of hypertension.