ELECTROSHOCK--NEUROBIOLOGY AND DRUG INTERACTION
ELECTROSHOCK--NEUROBIOLOGY AND DRUG INTERACTION
批准号:
3375440
负责人:
AMIRAM I BARKAI
金额:
$10.14万
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-09-01 至 1989-08-31
中文摘要
提出的研究旨在提供一些理解
英文摘要
The proposed research is directed to provide some comprehension of the
neurochemical mechanisms involved in the behavioral effects of electroshock
treatment (EST) by studying the relationships between different EST
parameters, resulting EEG seizures, and long-term changes in several
neurochemical correlates. Turnover rates of serotonin, and dopamine and
electrolyte transport in the cerebrospinal fluid (CSF) will be studied in
the intact brain of awake rabbits by a method which combines
cerebroventricular perfusion and isotope dilution techniques. Perfusion
experiments will be conducted before EST and 1, 7, and 14 days after a
series of repeated EST. Release of catecholamines into the perfusate will
also be studied. Separate experiments will be conducted to study long-term
effects of EST on neurotransmitters and imipramine receptor binding and on
neuronal uptake of neurotransmitters in several brain areas. In addition,
drug interaction with EST will be studied in relation to the EEG seizure
and the neurochemical changes: Initial studies will be conducted with
Lithium, Imipramine, Carbamezapine and Haloperidol.
期刊论文(14)
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Combined electroconvulsive and drug therapy.
电休克和药物联合治疗。
DOI:
--
发表时间:
1985
期刊:
Comprehensive therapy
影响因子:
--
作者:
[Barkai,AI]
通讯作者:
Barkai,AI
Diurnal and circannual variation in platelet 3H-imipramine binding: comparative data on normal and affectively ill subjects.
血小板 3H-丙咪嗪结合的昼夜变化:正常受试者和情感疾病受试者的比较数据。
DOI:
10.1159/000118425
发表时间:
1988
期刊:
Neuropsychobiology
影响因子:
3.2
作者:
[Baron,M, Barkai,A, Kowalik,S, Fieve,RR, Quitkin,F, Gruen,R]
通讯作者:
Gruen,R
Dopamine and serotonin metabolites in rat cerebroventricular fluid following withdrawal of haloperidol or electroshock treatment.
停用氟哌啶醇或电休克治疗后大鼠脑室液中的多巴胺和血清素代谢。
DOI:
10.1007/bf00555212
发表时间:
1984
期刊:
Psychopharmacology
影响因子:
3.4
作者:
[Barkai,AI, Kowalik,S, Reches,A]
通讯作者:
Reches,A
DOI:
10.1523/jneurosci.02-09-01322.1982
发表时间:
1982
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
[Barkai,AI, Meltzer,HL]
通讯作者:
Meltzer,HL
Alterations by antidepressants of cerebrospinal fluid formation and calcium distribution dynamics in the intact rat brain.
抗抑郁药对完整大鼠大脑中脑脊液形成和钙分布动态的改变。
DOI:
10.1016/0006-3223(87)90087-4
发表时间:
1987
期刊:
Biological psychiatry
影响因子:
10.6
作者:
[Barkai,AI, Nelson,HD]
通讯作者:
Nelson,HD
共 14 条
ARACHIDONIC ACID METABOLISM IN THE NERVOUS SYSTEM
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批准号:3436100
-
项目类别:
-
资助金额:$0.8万
-
财政年份:1988
-
负责人:AMIRAM I BARKAI
-
依托单位:
ELECTROSHOCK--NEUROBIOLOGY AND DRUG INTERACTION
-
批准号:3375439
-
项目类别:
-
资助金额:$9.22万
-
财政年份:1985
-
负责人:AMIRAM I BARKAI
-
依托单位:
ELECTROSHOCK--NEUROBIOLOGY AND DRUG INTERACTION
-
批准号:3375437
-
项目类别:
-
资助金额:$9.64万
-
财政年份:1985
-
负责人:AMIRAM I BARKAI
-
依托单位:
海外基金