ELECTROSHOCK--NEUROBIOLOGY AND DRUG INTERACTION

电击——神经生物学和药物相互作用

• 批准号: 3375440
• 负责人: AMIRAM I BARKAI
• 金额: $ 10.14万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375440
• 关键词: brain metabolism; carbamazepine; cerebral cortex; cerebrospinal fluid; chemical binding; dopamine; electroconvulsive therapy; electroencephalography; gamma aminobutyrate; haloperidol; homovanillate; imipramine; ionophores; lithium; neurotransmitter metabolism; perfusion; serotonin; synaptosomes

The proposed research is directed to provide some comprehension of the neurochemical mechanisms involved in the behavioral effects of electroshock treatment (EST) by studying the relationships between different EST parameters, resulting EEG seizures, and long-term changes in several neurochemical correlates. Turnover rates of serotonin, and dopamine and electrolyte transport in the cerebrospinal fluid (CSF) will be studied in the intact brain of awake rabbits by a method which combines cerebroventricular perfusion and isotope dilution techniques. Perfusion experiments will be conducted before EST and 1, 7, and 14 days after a series of repeated EST. Release of catecholamines into the perfusate will also be studied. Separate experiments will be conducted to study long-term effects of EST on neurotransmitters and imipramine receptor binding and on neuronal uptake of neurotransmitters in several brain areas. In addition, drug interaction with EST will be studied in relation to the EEG seizure and the neurochemical changes: Initial studies will be conducted with Lithium, Imipramine, Carbamezapine and Haloperidol.

建议的研究旨在提供一些理解的 电休克行为效应的神经化学机制 通过研究不同EST之间的关系， 参数，导致EEG癫痫发作，以及一些长期变化， 神经化学相关。 血清素和多巴胺的转换率， 将研究脑脊液（CSF）中的电解质转运， 清醒兔子的完整大脑， 脑室灌注和同位素稀释技术。 灌注 实验将在EST前和EST后1、7和14天进行。 一系列重复的EST。 释放到灌注液中的儿茶酚胺将 也被研究。 将进行单独的实验，以研究长期 EST对神经递质和丙咪嗪受体结合的影响， 在几个大脑区域中神经递质的神经元摄取。 此外，本发明还提供了一种方法， 将研究药物与EST的相互作用与EEG癫痫发作的关系 和神经化学变化：初步研究将进行与 锂、丙咪嗪、卡巴氮平和氟哌啶醇。

项目成果

Combined electroconvulsive and drug therapy.

电休克和药物联合治疗。

• 发表时间: 1985
• 期刊: Comprehensive therapy
• 作者: Barkai,AI

Diurnal and circannual variation in platelet 3H-imipramine binding: comparative data on normal and affectively ill subjects.

血小板 3H-丙咪嗪结合的昼夜变化：正常受试者和情感疾病受试者的比较数据。

• DOI: 10.1159/000118425
• 发表时间: 1988
• 期刊: Neuropsychobiology
• 影响因子: 3.2
• 作者: Baron,M;Barkai,A;Kowalik,S;Fieve,RR;Quitkin,F;Gruen,R
• 通讯作者: Gruen,R

Dopamine and serotonin metabolites in rat cerebroventricular fluid following withdrawal of haloperidol or electroshock treatment.

停用氟哌啶醇或电休克治疗后大鼠脑室液中的多巴胺和血清素代谢。

• DOI: 10.1007/bf00555212
• 发表时间: 1984
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Barkai,AI;Kowalik,S;Reches,A
• 通讯作者: Reches,A

Regulation of calcium entry into the extracellular environment of the rat brain.

钙进入大鼠大脑细胞外环境的调节。

• DOI: 10.1523/jneurosci.02-09-01322.1982
• 发表时间: 1982
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Barkai,AI;Meltzer,HL
• 通讯作者: Meltzer,HL

Alterations by antidepressants of cerebrospinal fluid formation and calcium distribution dynamics in the intact rat brain.

抗抑郁药对完整大鼠大脑中脑脊液形成和钙分布动态的改变。

• DOI: 10.1016/0006-3223(87)90087-4
• 发表时间: 1987
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Barkai,AI;Nelson,HD
• 通讯作者: Nelson,HD