ARACHIDONIC ACID METABOLISM IN THE NERVOUS SYSTEM

拟议会议的目标是审查 花生四烯酸神经生物学研究进展 及其代谢产物，包括甘草素， 血栓烷和白三烯，与它们的形成有关， 神经系统的作用方式和功能。 的作用 这些化合物在某些神经系统的发展， 也将讨论可能的精神障碍。 这样的 与AA相关的基础和临床研究问题会议， 它在神经系统中的衍生物应该填补了 广泛研究类花生酸的形成和功能 在生理系统中，除了神经系统和 迅速发展的信号转导基础研究领域， 神经元功能调节与脑缺血的临床研究 缺血、脑损伤、恢复期疾病和其他神经系统疾病 或精神疾病。 拟议的会议本身就是 跨学科方法作为讨论的主要领域 关注生物化学、生理学和病理学方面， AA及其在神经系统中的代谢产物。 尽可能多的 AA的形成、作用及其对环境的影响的基础研究 神经系统中的代谢物已经进行了研究， 动物，会议的一个主要目的是在 研究人员的主要兴趣是在临床护理 人类和那些与动物模型的工作。 预计在 这次会议将汇集研究人员与不同的 生物化学、神经科学和临床领域的背景 对动物和人类研究都感兴趣的人 的 将讨论以下主题：AA释放的调节和 神经系统中的AA级联反应 系统; AA及其代谢产物;信号转导;脑 血流量和AA代谢与脑损伤的关系， 缺血性损伤; AA代谢和惊厥性疾病，以及 AA及其代谢产物在正常和异常脑组织中的分布 功能：与疼痛、睡眠和精神障碍的关系。

The objectives of the proposed conference are to review the recent developments in the neurobiology of arachidonic acid (AA) and its metabolic products, including prostaglandins, thromboxanes and leukotrienes, in relation to their formation, mode of action and functions in the nervous system. The role of these compounds in the development of certain neurological and possibly psychiatric disorders will also be discussed. Such a conference on basic and clinical research issues related to AA and its derivatives in the nervous system should fill a gap between the extensively researched field of eicosanoids formation and function in physiological systems other than the nervous system and the rapidly developing fields of basic research on signal transduction, modulation of neuronal functions and clinical research on cerebral ischemia, brain injury, convalsive disorders and other neurological or psychiatric disorders. The proposed conference is inherently interdisciplinary in approach as the major areas of discussion concern the biochemical, physiological and pathological aspects of AA and its metabolites in the nervous system. As much of the basic research on the formation and effects of AA and its metabolites in the nervous system has been conducted with animals, a major aim of the conference is to bridge between researchers whose primary interest is in the clinical care of humans and those working with animal models. It is expected that this conference will bring together researchers with divergent backgrounds in the biochemical, neurosciences and clinical fields who have interest in both animal and human research. The following topics will be discussed: Modulation of AA release and metabolism in the nervous system; The AA cascade in the nervous system; AA and its metabolites in signal transduction; Cerebral blood flow and AA metabolism in relation to brain injury and ischemic damage; AA metabolism and convulsive disorders, and finally, AA and its metabolites in normal and abnormal brain functions: Relationship to pain, sleep and mental disorders.