A new approach to Science at the Life Sciences Interface

生命科学界面的科学新方法

• 批准号: EP/I017909/1
• 负责人: David Gavaghan
• 金额: $ 508.32万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI017909%2F1
• 关键词: new; approach; Science; Life; Sciences

The key scientific challenges of the next century require that we fundamentally advance current understanding of complex natural systems - ranging from how cells work and why/how they go wrong, to how the interaction of climate and ecosystems regulates the planet's life support system. We wish to understand how these systems behave at the functional level, and how this behaviour arises as a result of highly dynamic, strongly non-linear, tightly coupled interactions between component processes occurring across multiple spatial and temporal scales. Entirely new kinds of exploratory and predictive models and research strategies are needed to address these challenges. A new generation of theoretical methods and tools are needed to enable the recognition and exploitation of synergies and similarities that allow the translation of solutions between different scientific problem domains. Biological theories are evaluated against often imperfect data sets. There is a need for judicious selection and validation of the test bed against which any model is evaluated and the development of novel technologies for gathering new data identified as critical to complex system behaviour. The investigation of systems-level behaviour requires the identification of biological hypotheses that could not have been expressed by looking at individual phenomena alone. The unprecedented degree of complexity will mean that these quantitative models will be analytically intractable, and exploring their behaviour will be possible only through a computational approach. In short, a novel computational approach and environment is needed for doing this kind of science - and this does not exist in academia today. Progress requires both a cultural and technological change in the way in which mathematical and computational models, tools and software are developed, and a concomitant change in the way in which groups of scientists are trained to develop and use these approaches. This work can only be done in the context of real biological problems. This proposal brings together a consortium of partners from academia and industry, each of whom has begun to focus on differing but complementary aspects of these problems. These centres are the ideal community to attempt such a cultural shift since they are already dedicated to training the next generation of scientists who will pioneer this kind of science.

下个世纪的关键科学挑战要求我们从根本上推进当前对复杂自然系统的理解--从细胞如何工作以及它们为什么/如何出错，到气候和生态系统的相互作用如何调节地球的生命维持系统。我们希望了解这些系统在功能层面上的行为，以及这种行为是如何由于跨多个空间和时间尺度发生的组件过程之间的高度动态、强非线性、紧密耦合的相互作用而产生的。需要全新的探索性和预测性模型和研究战略来应对这些挑战。需要新一代理论方法和工具，以便能够认识和利用协同作用和相似性，以便在不同的科学问题领域之间转换解决办法。生物学理论是根据经常不完美的数据集进行评估的。需要明智地选择和确认评估任何模型所依据的试验台，并开发新的技术，以收集被认为对复杂系统行为至关重要的新数据。对系统级行为的调查需要确定生物学假说，而这些假说不能仅通过观察个别现象来表达。前所未有的复杂程度将意味着，这些量化模型在分析上将是难以处理的，而探索它们的行为将只能通过计算方法。简而言之，进行这类科学需要一种新的计算方法和环境--而这在今天的学术界中是不存在的。进步既需要在开发数学和计算模型、工具和软件的方式上进行文化和技术变革，也需要相应地改变培养开发和使用这些方法的科学家群体的方式。这项工作只能在真正的生物学问题的背景下进行。这项提议汇集了一个由学术界和工业界的合作伙伴组成的财团，他们中的每一个人都开始关注这些问题的不同但互补的方面。这些中心是尝试这种文化转变的理想社区，因为它们已经致力于培养下一代将开创这种科学的科学家。

项目成果

Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle.

• DOI: 10.1242/dev.126359
• 发表时间: 2015-11-15
• 期刊: Development (Cambridge, England)
• 作者: Atwell K;Qin Z;Gavaghan D;Kugler H;Hubbard EJ;Osborne JM
• 通讯作者: Osborne JM

Additional file 3: Figure S3. of Sexual conflict explains the extraordinary diversity of mechanisms regulating mitochondrial inheritance

附加文件 3：图 S3。

• DOI: 10.6084/m9.figshare.c.3915010_d3
• 发表时间: 2017
• 作者: Arunas Radzvilavicius

Additional file 1: Figure S1. of Sexual conflict explains the extraordinary diversity of mechanisms regulating mitochondrial inheritance

附加文件 1：图 S1。

• DOI: 10.6084/m9.figshare.c.3915010_d1
• 发表时间: 2017
• 作者: Arunas Radzvilavicius

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.

• DOI: 10.1038/srep40620
• 发表时间: 2017-01-17
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Aston D;Capel RA;Ford KL;Christian HC;Mirams GR;Rog-Zielinska EA;Kohl P;Galione A;Burton RA;Terrar DA
• 通讯作者: Terrar DA

Scientists and software - surveying the species distribution modelling community

• DOI: 10.1111/ddi.12305
• 发表时间: 2015-03-01
• 期刊: DIVERSITY AND DISTRIBUTIONS
• 影响因子: 4.6
• 作者: Ahmed, Sadia E.;McInerny, Greg;Joppa, Lucas N.
• 通讯作者: Joppa, Lucas N.