HIV ASSOCIATED HEART DISEASE

有几条证据证实了 与艾滋病毒感染和心脏病相关的综合征， 人类 具有临床意义的充血性心肌病， 超声心动图异常是常见的。 本提案中描述的项目将开发自然历史数据 关于发病率，临床过程，预后意义， 非侵入性评估的作用和治疗效果 抗病毒和免疫抑制剂对HIV相关心脏的影响 疾病 这一建议将建立一个跨学科的 从三个地区招募患者的合作研究工作 哥伦比亚的学术机构， 人口。 研究小组将包括所有必要的 研究HIV相关心脏病自然史的组成部分 疾病，并提供有关影响的重要数据 药物干预的发展和进程， 心脏病 HIV感染者的心脏组织病理学异常 在两个尸体样本中都发现了感染 和肌内膜活检样本。 目前尚不清楚， 观察到的异常是由于1）直接感染 心脏细胞与艾滋病毒，2）损害从不同的感染 剂，或3）免疫介导的心脏细胞损伤刺激 HIV或其他感染的存在。 项目2本 该提案将评估一些可能的机制 导致了艾滋病心脏病的发生

Several lines of evidence have confirmed the association between the syndromes associated with HIV infection and heart disease in humans. Clinically significant congestive cardiomyopathy and echocardiographic abnormalities are commonly found. The first project described in this proposal will develop natural history data regarding the incidence, clinical course, prognostic significance, role of non-invasive evaluation and effects of treatment with anti-viral and immunosuppressive agents on HIV-associated heart disease. This proposal will establish an interdisciplinary cooperative research effort enrolling patients from three District of Columbia academic institutions with diverse patient populations. The research group will contain all the necessary components to study the natural history of HIV-associated heart disease and provide important data regarding the effects of pharmacologic intervention on the development and course of heart disease. Cardiac histopathologic abnormalities in patients with HIV infection have been demonstrated in both post-mortem specimens and endomyocardial biopsy samples. It is not known whether the observed abnormalities are due to 1) direct infection of cardiocytes with HIV, 2) damage from a different infectious agent, or 3) immune-mediated damage of heart cells stimulated by the presence of HIV or other infection. Project 2 of this proposal will evaluate a number of possible mechanisms underlying the development of HIV heart disease.