HORMONE RHYTHMS: METABOLIC SIGNIFICANCE IN DEPRESSION

激素节律：抑郁症中的代谢意义

• 批准号: 3375048
• 负责人: Robert T. Rubin
• 金额: $ 21.79万
• 依托单位: LOS ANGELES COUNTY HARBOR-UCLA MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375048
• 关键词: adolescence (12-20); adrenocorticotropic hormone; adult human (21+); antidepressants; blood chemistry; circadian rhythms; clinical depression; corticotropin releasing factor; cortisol; dexamethasone; disease /disorder classification; electroconvulsive therapy; endocrine pharmacology; hormone regulation /control mechanism; human subject; hypothalamus; laboratory rabbit; magnetic resonance imaging; major depression; neuroendocrine system; psychobiology; radioimmunoassay; secretion; thyrotropin releasing hormone

This is a study of the neuroendocrinology of severe endogenous depression, including anterior pituitary hormone secretion patterns, their regulation of peripheral steroid hormones, and the integrity of their control mechanisms as reflected by responses to pertubation tests including thyrotropin releasing hormone, luteinizing hormone releasing hormone, and dexamethasone suppression. Both male and female endogenously depressed patients are being studied under a three day protocol with frequent blood sampling being done for the elucidation of multiple hormone secretion patterns. The patients are studied after one week of hospitalization before any treatment, after one month of tricyclic antidepressant medication of ECT, and several months following discontinuation of treatment. The patients are diagnosed according to the Research Diagnostic Criteria, and psychological ratings for degree of depression are performed at each stage of the patients' illnesses.

这是一项关于严重内源性抑郁症的神经内分泌学研究， 包括垂体前叶激素分泌模式，它们对 外周类固醇激素，及其控制机制的完整性， 通过对包括促甲状腺激素释放在内的插管试验的反应来反映 激素、促黄体生成激素释放激素和地塞米松抑制。 男性和女性内源性抑郁症患者都在一个 三天方案，频繁采血以进行说明 多种激素分泌模式的证据 一周后对患者进行研究 在任何治疗前住院，三环治疗一个月后 抗抑郁药物ECT，以及停药后数月 治疗。 根据研究诊断对患者进行诊断 抑郁程度的标准和心理评级是在 病人疾病的每个阶段。