HORMONE RHYTHMS: METABOLIC SIGNIFICANCE IN DEPRESSION

激素节律：抑郁症中的代谢意义

• 批准号: 3375052
• 负责人: Robert T. Rubin
• 金额: $ 17.54万
• 依托单位: LOS ANGELES COUNTY HARBOR-UCLA MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375052
• 关键词: adrenocorticotropic hormone; blood chemistry; cerebrospinal fluid; circadian rhythms; clomiphene; dexamethasone; dihydroxyphenylalanine; disease /disorder classification; endocrine disorder diagnosis; endocrine pharmacology; follicle stimulating hormone; gonadotropin releasing factor; hormone regulation /control mechanism; human subject; hypothalamic pituitary axis; hypothalamus; luteinizing hormone; mental disorder chemotherapy; neuroendocrine system; norepinephrine; pituitary gonadal axis; prolactin; psychobiology; radioimmunoassay; secretion; somatotropin; thyrotropin releasing hormone

This is a study of the neuroendocrinology of severe endogenous depression, including anterior pituitary hormone secretion patterns, their regulation of peripheral steroid hormones, and the integrity of their control mechanisms as reflected by responses to pertubation tests including thyrotropin releasing hormone, luteinizing hormone releasing hormone, and dexamethasone suppression. Both male and female endogenously depressed patients are being studied under a three day protocol with frequent blood sampling being done for the elucidation of multiple hormone secretion patterns. The patients are studied after one week of hospitalization before any treatment, after one month of tricyclic antidepressant medication of ECT, and several months following discontinuation of treatment. The patients are diagnosed according to the Research Diagnostic Criteria, and psychological ratings for degree of depression are performed at each stage of the patients' illnesses.

这是一项关于严重内源性抑郁症的神经内分泌学研究， 包括垂体前叶激素的分泌模式，它们对 外周类固醇激素及其控制机制的完整性，如 反映在对包括促甲状腺激素释放在内的扰动试验的反应上 激素、黄体生成素释放激素和地塞米松抑制。 男性和女性内源性抑郁症患者正在接受一项 三天的协议，并进行频繁的血液采样以澄清 多种荷尔蒙分泌模式。一周后对患者进行研究 在三环类药物治疗一个月后，在任何治疗前住院 ECT的抗抑郁药物，以及停药后几个月 关于治疗的问题。根据研究诊断对患者进行诊断 抑郁程度的标准和心理评分是在 患者病情的每一阶段。