Engineering Structural Tissues for Clinical Medicine

临床医学工程结构组织

• 批准号: 6554605
• 负责人: Robert T. Rubin
• 金额: $ 10.28万
• 依托单位: PITTSBURGH TISSUE ENGINEERING INITIATIVE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6554605
• 关键词: Engineering; Structural; Tissues; Clinical; Medicine

DESCRIPTION (provided by applicant): The Pittsburgh Tissue Engineering Initiative (PTEI) is the applicant organization for this Institutional NRSA to support postdoctoral fellowship training in musculoskeletal tissue engineering (TE) for clinical applications in medicine and surgery. PTEI is a not-for-profit organization whose mission is to foster TE research and education regionally, nationally, and internationally. The major regional academic institutions (Allegheny General Hospital, Carnegie Mellon University, Children's Hospital of Pittsburgh, Duquesne University, University of Pittsburgh, and University of Pittsburgh Medical Center) are members of PTEI and provide the venues for TE academic research and development. PTEI supports these organizations through seed research grants and educational programs, including its Postdoctoral Fellowship Program. As well, PTEI fosters university-academic relationships with the burgeoning TE biotechnology commercial enterprise. The PTEI Postdoctoral Fellowship Program began in January 2000 and is special in that each fellow is assigned a primary and a secondary mentor, chosen from the member institutions and based on the correspondence between the mentors' expertise and the fellow's prior training and desired focus within TE. The two mentors may be in the same or different institutions. The mentors include M.D.s, D.M.D.s, D.D.S.s, Ph.D.s, and those with dual degrees; emphasis is on clinician-basic scientist pairing of mentors. The supporting facilities and didactic opportunities thus span the major academic institutions in Pittsburgh. The Fellowship is two years long, with an option for a third year. Each fellow spends 2/3-3/4 of the two-year fellowship in the primary mentor's laboratories and the rest with the secondary mentor; these assignments may be consecutive or concurrent. Additional ad hoc experiences are arranged as needed. An introductory course in starting a biotechnology company, taught at Carnegie Mellon University, and formal instruction in the responsible conduct of research are required didactic activities. The primary mentor's institution manages the administrative aspects of the fellowship, and PTEI contractually provides monetary support to that institution. The first two post-doctoral fellows began in early 2000, and the second two began in early 2001. Advertising for the third round will begin in February 2002. A local PTEI Executive Committee provides administrative oversight for the Fellowship Program, and a larger Scientific Advisory Committee is being established. Initial fellowship funding has been provided by both local and federal funding, but continuation and expansion of the program depends on wider extramural support. Musculoskeletal TE is the current major strength of PTEI's member institutions; this application, therefore, is focused on this area of TE and its clinical application.

描述（由申请人提供）：匹兹堡组织工程计划（PTEI）是该机构NRSA的申请组织，旨在支持肌肉骨骼组织工程（TE）在医学和外科临床应用方面的博士后培训。PTEI是一个非营利性组织，其使命是促进区域、国家和国际上的教育研究和教育。主要的地区性学术机构（阿勒格尼总医院、卡内基梅隆大学、匹兹堡儿童医院、杜肯大学、匹兹堡大学和匹兹堡大学医学中心）都是PTEI的成员，并为TE的学术研究和发展提供场所。PTEI通过种子研究资助和教育项目支持这些组织，包括博士后奖学金项目。此外，PTEI还与蓬勃发展的TE生物技术商业企业建立了大学与学术的关系。PTEI博士后奖学金计划开始于2000年1月，它的特殊之处在于，每个研究员都被分配到一个主要和一个次要导师，这些导师是从成员机构中挑选出来的，并根据导师的专业知识与研究员之前的培训和期望在TE中的重点之间的对应关系。两位导师可能在同一个或不同的机构。导师包括医学博士、医学博士、哲学博士、博士和双学位；重点是临床医生和基础科学家的导师配对。因此，配套设施和教学机会跨越匹兹堡的主要学术机构。该奖学金为期两年，可选择第三年。每位研究员在两年的奖学金中有2/3-3/4的时间在主要导师的实验室中度过，其余时间在次要导师那里度过；这些任务可以是连续的，也可以是并发的。根据需要安排额外的临时经验。卡耐基梅隆大学开设的开办生物技术公司的入门课程，以及负责任的研究行为的正式指导，都是必需的教学活动。主要导师的机构管理奖学金的行政方面，PTEI以合同方式向该机构提供资金支持。2000年初开始招收前两名博士后，2001年初开始招收后两名博士后。第三轮广告将于2002年2月开始。当地的PTEI执行委员会为奖学金计划提供行政监督，并且正在建立一个更大的科学咨询委员会。最初的奖学金资金由地方和联邦基金提供，但项目的继续和扩大取决于更广泛的外部支持。肌肉骨骼TE是PTEI成员机构目前的主要优势；因此，本申请主要针对TE的这一领域及其临床应用。