ULTRASONIC CONTRAST BLOOD FLOWMETRY

超声波对比血流计

• 批准号: 3366197
• 负责人: K KIRK SHUNG
• 金额: $ 6.9万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3366197
• 关键词: animal tissue; biomedical equipment development; contrast media; indicator dilution test; online computer; pulmonary circulation; ultrasound blood flow measurement

Great strides have recently been made in the development of nontoxic transpulmonary ultrasonic contrast agents and time domain blood flowmetry. The proposed research is a marriage of these two new developments. Time domain blood flow estimation although has been proven to be feasible and to have several advantages over ultrasonic Doppler methods suffers from low signal to noise ratio because the signal backscattered from blood is extremely weak, By using ultrasonic contrast agents, this problem can be circumvented. Preliminary results have demonstrated the potential of ultrasonic contrast blood flowmetry. In this research, the following approaches on time domain blood flowmetry will be pursued in vitro in conjunction with the utilization of ultrasonic contrast media in a mock flow loop. (1) Mean blood flow velocity will be estimated from a measurement of the time course of the variation in the ultrasonic attenuation of blood following the bolus injection of a contrast agent based upon the indicator dilution principle. (2) Mean velocity and velocity profile in a vessel will be determined using an optical correlator from recorded video ultrasonic images following bolus injection of a contrast agent. (3) Flow field in 2-D will be determined using a two-probe arrangement from cross-correlation of the RF signals detected by these two probes. The proposed work is exploratory in nature and intends primarily to show the feasibility of these approaches in a fundamental way. Once the feasibility of an approach is established, research in a larger scale involving animals will ensue.

近年来，我国在开发无毒 超声造影剂和时域血流测定法。 拟议的研究是这两个新发展的结合。 时间 域血流估计虽然已经被证明是可行的， 与超声多普勒方法相比有几个优点， 信噪比，因为从血液反向散射的信号 通过使用超声波造影剂，这个问题可以 规避。 初步结果表明， 超声造影血流测定法 在这项研究中，以下 时域血流测定的方法将在体外进行， 结合超声造影剂的使用， 流动回路 (1)平均血流速度将根据 测量超声波中的变化的时间过程 造影剂团注后的血液衰减 基于指示剂稀释原理。 (2)平均速度和 将使用光学相关器来确定船舶中的速度分布 从团注后记录的视频超声图像， 造影剂。 (3)二维流场将使用双探针来确定 通过这两个装置检测到的RF信号的互相关， probes. 拟议的工作是探索性的，主要是为了表明 这些方法的可行性。 一旦 一种方法的可行性已经建立，在更大的范围内进行研究 动物也会参与进来